Novel role of Hippo effector YAP1 as a rheostat controlling inflammation in dendritic cells YAP1 regulates inflammatory responses in human dendritic cells under hypoxic conditions by controlling oxidative stress, signaling pathway activation, and

Sara Monaci and colleagues identify a "Novel role of Hippo effector #YAP1 as a rheostat controlling #Inflammation in #DendriticCells"

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Using the phosphor-YAP1 (Ser128) antibody from antibodies.com, the group also revealed increased #YAP1 #phosphorylation in persister cells. We’re proud that our product, helped uncover the potential role of YAP-TEAD activity in supporting cell survival.

Finally, our work reveals a hidden mechanical state of regeneration where tissue stiffening instruct cells to transit into regenerative states...

Far from perfect but always looking forward to hearing from you #Regeneration #Mechanobiology #Piezo1 #Yap1 #Xenopus #FrogPower #Morphogenesis

... then we found that cells sense this stiffening via #Piezo1, which in turn activates #Yap1. This Piezo1–Yap1 cascade relays tissue mechanics into transcriptional programs that support the transition into regenerative bud states...

#YAP1 #SDC1 #proteoglycan #KRAS #glycotime #cancer
Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers.

The July Issue of @CellChemBiol is live! Read it here: http://dlvr.it/T9mKhz #smoothened #hedgehog #optogenetics #NaVs #Rho-GTPase #YAP1 #MesenchymalStemCells #K2Pchannels #PROTAC #deubiquitylase #chromatin #PARPinhibitors

Luigi Luigidaweb GIF ALT: Luigi Luigidaweb GIF

We then deeply investigated the vulnerabilities and molecular regulators of VC-Resist with the hope of targeting this invasive and resistant cell state in the future. #YAP1 #FGFR1 (5/11)