Over the last decade, the attempt to produce MR images that provide bony detail comparable to CT has resulted in multiple different techniques including various VIBE sequences, UTE/ZTE sequences, and synthetic CT. StarVIBE is a sequence primarily designed for free-breathing body and pediatric imaging, but it also offers several advantages for 3D bone imaging. While StarVIBE does not have the very short echo times (TEs) of ultra-short-TE and zero-TE sequences, its repetition time (TR) and TE are still relatively short compared to other pulse sequences. This characteristic of volume interpolated breath-hold examination (VIBE) makes it a suitable candidate for 3D bone imaging. The StarVIBE sequence for bone imaging is isometric and provides high-resolution images that are reformattable. The images also provide excellent cortical and trabecular detail in bony structures, as well as excellent visualization of soft tissue mineralization. The sequence also stands up well when dealing with metal artifact and is comparable to metal reduction sequences in its ability to reduce metal artifact. Additionally, there is no loss of signal when relevant anatomy is distant from the isocenter, which is particularly useful when imaging joints such as the shoulder and the hip.

StarVIBE for Bone Imaging by Erin Moran, MD (@duke-university.bsky.social, Durham, NC, USA) and Eddie Song BS, RT(R)(MR)(MRSO) (Siemens Healthineers).

🔗 www.magnetomworld.siemens-healthineers.com/clinical-cor...

#MRI #MSK #BoneImaging #RadSky #MSKSky

Blake GM, Puri T, Siddique M, Frost ML, Moore AEB, Fogelman I. Site specific measurements of bone formation using [18F] sodium fluoride PET/CT. Quant Imaging Med Surg. 2018 Feb;8(1):47-59. doi: 10.21037/qims.2018.01.02. PMID: 29541623; PMCID: PMC5835654.

What are precision errors, and what do they mean in [18F]NaF PET imaging? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #boneimaging
doi: 10.21037/qims.2018.01.02

Even-Sapir E, Metser U, Mishani E, Lievshitz G, Lerman H, Leibovitch I. The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP Planar bone scintigraphy, single- and multi-field-of-view SPECT, 18F-fluoride PET, and 18F-fluoride PET/CT. J Nucl Med. 2006 Feb;47(2):287-97. PMID: 16455635.

[18F]NaF PET for Detecting Bone Metastases in Prostate Cancer Patients #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #precisionmedicine #precisionimaging #BoneImaging #BoneRemodeling #EarlyDetection #prostatecancer #cancer jnm.snmjournals.org/content/47/2...

Puri T, Frost ML, Moore AEB, Cook GJR, Blake GM. Input function and modeling for determining bone metabolic flux using [18 F] sodium fluoride PET imaging: A step-by-step guide. Med Phys. 2023 Apr;50(4):2071-2088. doi: 10.1002/mp.16125. Epub 2022 Dec 17. PMID: 36433629.

[18F] NaF PET Ki vs SUV? #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #precisionmedicine #precisionimaging #BoneResearch #ImagingInnovation #BoneImaging #BoneRemodeling #EarlyDetection #ArthritisAwareness doi: 10.1002/mp.16125

Schirrmeister H, Glatting G, Hetzel J, Nüssle K, Arslandemir C, Buck AK, Dziuk K, Gabelmann A, Reske SN, Hetzel M. Prospective evaluation of the clinical value of planar bone scans, SPECT, and (18)F-labeled NaF PET in newly diagnosed lung cancer. J Nucl Med. 2001 Dec;42(12):1800-4. PMID: 11752076. https://jnm.snmjournals.org/content/42/12/1800.long

[18F]NaF PET is more accurate for detecting bone spread than planar bone scans or SPECT #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #precisionmedicine #precisionimaging #BoneResearch #ImagingInnovation #BoneImaging
jnm.snmjournals.org/content/42/1...

Ota N, Kato K, Iwano S, Ito S, Abe S, Fujita N, et al. Comparison of 18F-fluoride PET/CT, 18F-FDG PET/CT and bone scintigraphy (planar and SPECT) in detection of bone metastases of differentiated thyroid cancer: a pilot study. Br J Radiol 2014;87:20130444.

[18F]NaF PET in differentiated thyroid carcinoma
#18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #BoneResearch #BoneImaging #BoneRemodeling doi: 10.1259/bjr.20130444

Special Issue Information (Submission Deadline: 20 May 2025) #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #BoneResearch #BoneImaging #BoneRemodeling #EarlyDetection www.mdpi.com/journal/jcm/...

T-scores help clinicians to interpret the measurements of bone mineral density (BMD) made using DEXA (Dual-Energy X-ray Absorptiometry) scans and find out whether patients have osteoporosis or other bone health issues. T-score compares a patient’s BMD measurement to the average BMD of a group of healthy young adults of the same sex and ethnic background and is calculated using the following equation: T-score = (Patient's BMD - Mean BMD of Young Adult Reference Group) / (Standard Deviation of Young Adult Reference Group BMD) Why it matters: T-scores indicate the patient’s risk of suffering a fragility fracture and their bone health status. A lower T-score means weaker bones and a higher risk of fractures. T-score categories (as defined by the World Health Organisation) are normal: T-score ≥ -1.0: Osteopenia (low bone mass): T-score between -1.0 and -2.5; Osteoporosis: T-score ≤ -2.5; Severe Osteoporosis: T-score ≤ -2.5 with fractures.

What are the T-score values used in DEXA, and how are they calculated? #BoneHealth #JointCare #HealthyBones #Osteoarthritis #BoneResearch #JointHealth #ImagingInnovation
#StrongBones #BoneWellness #CartilageCare #BoneImaging #BoneStrength www.linkedin.com/in/tanuj-pur...

Kuo J, Foster C, Shelton D. Particle disease on fluoride-18 (NaF) PET/CT imaging. J Radiol Case Rep. 2011;5(5):24-30. doi: 10.3941/jrcr.v5i5.697. Epub 2011 May 1. PMID: 22470793; PMCID: PMC3303443.

Particle Disease on [18F]NaF PET-CT #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneHealth #Osteoarthritis #BoneResearch #ImagingInnovation #BoneWellness #BoneImaging #BoneRemodeling doi: 10.3941/jrcr.v5i5.697

Usmani S, Rasheed R, Al Kandari F. Textitis as Seen on 18F-NaF Imaging Using an Ultra-High-Resolution Positron Emission Mammography Scanner. J Nucl Med Technol. 2020 Jun;48(2):181-183. doi: 10.2967/jnmt.119.235986. Epub 2020 Feb 28. PMID: 32111663.

Smartphone Overuse Strain Caught on [18F]NaF PET-CT #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #BoneHealth #JointCare #HealthyBones #BoneResearch #ImagingInnovation #BoneWellness #BoneImaging #BoneRemodeling #EarlyDetection doi: 10.2967/jnmt.119.235986

Revision of the 1994 World Health Organization T-score definition of osteoporosis for use in older East Asian women and men to reconcile it with their lifetime risk of fragility fracture - Skeletal Ra... The 1994 WHO criterion of a T-score ≤ -2.5 for densitometric osteoporosis was chosen because it results in a prevalence commensurate with the observed lifetime risk of fragility fractures in Caucasian...

New T-score Guidelines for Osteoporosis in East Asians #BoneHealth #JointCare #HealthyBones #Osteoarthritis #BoneResearch #JointHealth #ImagingInnovation
#StrongBones #BoneWellness #CartilageCare #BoneImaging #BoneStrength #BoneRemodeling #EarlyDetection #ArthritisAwareness doi.org/10.1007/s002...

Papadakis GZ, Jha S, Bhattacharyya T, Millo C, Tu TW, Bagci U, Marias K, Karantanas AH, Patronas NJ. 18F-NaF PET/CT in Extensive Melorheostosis of the Axial and Appendicular Skeleton With Soft-Tissue Involvement. Clin Nucl Med. 2017 Jul;42(7):537-539. doi: 10.1097/RLU.0000000000001647. PMID: 28319505; PMCID: PMC5453819.

[18F]NaF PET for Melorheostosis #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneResearch #ImagingInnovation #BoneImaging #BoneRemodeling #EarlyDetection
doi: 10.1097/RLU.0000000000001647

Papadakis GZ, Millo C, Bagci U, Blau J, Collins MT. 18F-NaF and 18F-FDG PET/CT in Gorham-Stout Disease. Clin Nucl Med. 2016 Nov;41(11):884-885. Multiple foci of intensely increased 18F-NaF activity located in the right posterior ribs (Fig. 2A: 18F-NaF MIP image red arrows; Fig. 2B: axial fused 18F-NaF-PET/CT image white arrow, SUVmax: 84,5) were associated with areas of incipient bone resorption (Fig. 2C: axial chest CT-image bone window, white arrow) supporting the application of 18F-NaF as the optimal bone-seeking PET-radiopharmaceutical to assess GSD activity.

[18F]NaF PET-CT in Gorham-Stout Disease #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging #BoneResearch #ImagingInnovation #BoneImaging #BoneRemodeling #EarlyDetection doi:10.1097/RLU.0000000000001369

PET/MRI of right knee of 36 year male having KL grade 0 showing high tracer uptake in medial central femur region (B) without any morphological changes in corresponding sagittal T2 SPIR image (A) also spatially correlated on fused PET/MRI image (C). Grade 1 osteophyte in lateral posterior tibial region in sagittal T1 TSE image (D) showing increased tracer uptake in PET (E) better appreciated on fused PET/MRI image (F). The T2 ∗ relaxometry cartigram overlayed on sagittal T2 SPIR image (G) showed mild changes in the cartilage of medial aspect of tibia (Green arrow for osteophytes and yellow arrow for region having intense tracer uptake without morphological changes). Physiological uptake was noted at tendon insertion sites on patella & tibial tuberosity. Jena A, Goyal N, Vaishya R. 18F-NaF simultaneous PET/MRI in osteoarthritis: Initial observations with case illustration. J Clin Orthop Trauma. 2021 Aug 26;22:101569. doi: 10.1016/j.jcot.2021.101569. PMID: 34513587; PMCID: PMC8411223. Keywords: Osteoarthritis (OA), PET/MRI, 18F–NaF, Standard uptake value (SUV)

[18F]NaF PET in osteoarthritis #18FNaF #BoneHealth #JointCare #HealthyBones #Osteoarthritis #BoneResearch #JointHealth #ImagingInnovation #StrongBones #BoneWellness #CartilageCare #BoneImaging #BoneRemodeling #EarlyDetection #ArthritisAwareness doi: 10.1016/j.jcot.2021.101569