This fungal yeast was called Histoplasma on biopsy. This diagnosis was later confirmed by cultures. How often does this approach go wrong?

#pathsky #idpath

Read more here in @IJSPjournal :
journals.sagepub.com/doi/10.1177/...

Do you see what I see? 😆🔬

Pseudoepitheliomatous hyperplasia and dermal granulomatous inflammation with multinucleated giant cells. That’s it? Nope, keep looking and you will find the cause of these histopathologic changes—Medlar bodies of chromoblastomycosis!

#dermpath #IDpath #MDACCpath

Adrenal necrosis
GMS and PAS stains show small uniform oval, narrow based budding yeasts.
Dx. Adrenal histoplasmosis #adrenalgland #histology #pathsky #histoplasmosis #skypath #pathology #idpath

Cryptococcus neoformans
Immunocompromised host
: lung, CNS, cutaneous manifestation
Infected from: bird droppings, soil
✅️varying size yeasts with thin walls
✅️encapsulated by thick capsule of glucuronoxylomannan
▶️ GMS+, mucicarmine+, PAS+
#pathsky #pathology #IDpath #lungpath #cryptococcus

✅️Talaromyces marneffei
Previously called
" Penicillium marneffei "
▶️Dimorphic fungi
▶️Intracytoplasmic organisms -sausage shape (due to fission, not budding)
#pathsky #pathology #IDpath
#histology #talaromyces

Tuberculous(TB) spondylitis (Pott disease)
✅️ AFB positive bacilli
#pathology #AFB #tuberculosis #pathsky #IDpath