Analysis and engineering of quorum sensing-based communications between bacteria and fungi | mBio In natural environments, bacteria and fungi nearly always coexist, and their interactions play pivotal roles in maintaining human health (1, 2) and driving industrial processes (3). In the gut, for in...

Analysis and engineering of quorum sensing-based communications between bacteria and fungi

#mBio MiniReview

journals.asm.org/doi/10.1128/...

Interaction of C. glabrata wild type and C. albicans yeast-locked efg1ΔΔ/cph1ΔΔ mutant cells with macrophages.

Should I stay or should I go? Research in #mBio suggests the fungus Candida glabrata may actively prolong the part of its life spent inside macrophages, which could contribute to immune evasion, antifungal resistance and potential recurrence of infection. asm.social/2Q2

A teichoic acid-like wall modification associated with immune suppression is socially regulated in Streptococcus pyogenes | mBio Streptococcus pyogenes is a major human pathogen, responsible for diverse clinical manifestations of both superficial and invasive infections, and can lead to post-infection sequelae like rheumatic he...

A teichoic acid-like wall modification associated with immune suppression is socially regulated in Streptococcus pyogenes

#mBio

journals.asm.org/doi/10.1128/...

Effect of IgM, IgG, and IgA on Cn morphology. (A) Scanning electron microscopy of Cn incubated for 48 h with (A and B) PBS (control), (C and D) IgA, (E and F) IgM, and (G and H) IgG. (B) Total cellular size of Cn after 48 h and (C) concentrations of Cn GXM shed (exo-GXM) into culture supernatant after 24 and 48 h. Statistical analysis was performed using a one-way ANOVA matched pairs and a Bonferroni multiple-comparisons test. Graphs show means ± SD from at least three independent experiments. *P < 0.05 and **P < 0.03.

IgA has major effects on Cryptococcus neoformans (Cn) growth, morphology & protein synthesis, lending plausibility to the hypothesis that reported reductions in IgA levels in HIV-associated cryptococcal meningitis may influence Cn pathogenesis. #mBio: asm.social/2OV

Overview of Mtb-phagocyte interactions depicting the diverse functions altered by Mtb lipids.

Mycobacterium tuberculosis cell surface lipids play multifaceted roles in infection, immune evasion, intracellular persistence, granuloma formation and more. What are the latest insights on "the lipid language of tuberculosis?" Find out in #mBio: asm.social/2Oq

Fungal extracellular vesicles mediate conserved cross-species communication and immunomodulation | mBio Currently, no vaccines exist to prevent fungal infections, underscoring the need for new therapies. As fungal diseases increase globally, understanding fungal biology is essential to identifying treat...

Fungal extracellular vesicles mediate conserved cross-species communication and immunomodulation

-in #mBio

journals.asm.org/doi/10.1128/...

Construction of OROV mRNA vaccine

Oropouche virus (OROV) is reemerging in the Americas. A virus-like particle-based mRNA vaccine presented in #mBio elicits potent and durable neutralizing antibodies against both historical and circulating OROV strains. asm.social/2Mw

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#PHILIPPE #MARTIN #DEREVA WA #MBIO ZA #MAGARI
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#MOTLALEPULA #CHABAKU
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#HENOKO
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Fluorescence increases over time in mother cells due to aggregates.

How does E. coli age? According to this #mBio study, the the decisive factor driving growth decline in E. coli is not the presence of protein aggregates, but the fraction of the intracellular space they occupy. Learn more: asm.social/2KZ

Characterization of the effects of diet on gut bacterial diversity, composition, and community structure

A dietary long-chain fatty acid (oleic acid) enhances Candida albicans colonization of the murine gut partly by modifying the fungal cell surface. The findings highlight the importance of the fungal cell wall in interacting with intestinal mucus. #mBio: asm.social/2Jo

Impact of host gene perturbation on HIV-1 versus the impact of HIV-1 perturbation on host gene.

Presumably, HIV-1 transcription passively follows host gene activity at the HIV-1 integration site. However, research in #mBio suggests this is not the case, and that HIV-1 promoter-driven transcriptional activity dominated over the host promoter activity. asm.social/2It

A sketched inference for the dilution at the complexity threshold and potential compositions of sub-communities after cultivation.

Microbiology Monday: Who becomes dominant in a microbial community? Competitive traits nominate species, but rare microbes “vote” the winner through complex interactions. Learn more in #mBio: asm.social/2Ib

Spn-H2O2 modifies mitochondrial morphology, induces aggregation, and promotes mislocalization.

How does Streptococcus pneumoniae (Spn) manipulate host metabolism to promote its survival? In #mBio, researchers reveal a novel strategy whereby Spn-derived hydrogen peroxide disrupts the host TCA cycle, reprogramming metabolism in lung epithelial cells. asm.social/2Gx

Diary from the Sea - #2 Into the world of Algae If you ever visit your favorite seaside spot — especially those areas where seaweed tends to pile up — you might stumble upon an incredible mix of creatures.

Second episode of my substack out, I explore the world of algae in this one and show you a few specimens I had the pleasure to record. Have a look! #marinebiology #substack #mbio

open.substack.com/pub/anastasi...

A sulfur-containing nucleoside antibiotic from Photorhabdus | mBio Introducing novel antibiotics is essential to counter the spread of drug-resistant pathogens. Here, we report the discovery of 4′-thiothymidine (4′sT), a nucleoside antibiotic from the nematode symbio...

A sulfur-containing nucleoside antibiotic from Photorhabdus

#mBio from Kim Lewis

journals.asm.org/doi/10.1128/...

Aspergillus fumigatus effector crpA orchestrates host prostaglandin signaling to promote fungal virulence - PubMed Conidia are the primary infection structures in <i>Aspergillus fumigatus</i>, the etiologic agent of aspergillosis. Here, we characterized CrpA (a cysteine-rich protein), a conidial surface-associated protein important for fungal e …

New study reveals the A. fumigatus effector CrpA hijacks host prostaglandin signaling to boost virulence — a promising antifungal target.
🔗 pubmed.ncbi.nlm.nih.gov/40938145/

#Aspergillus #FungalPathogenesis #Immunology #CrpA #mBio #HostPathogenInteraction #Antifungals

Mechanical stress in the S. aureus cell wall during the cell cycle. (A) As the cell cycle progresses, stress at the equator decreases due to growth of the septum while the stress remains unchanged at the pole. The stress distributions shown here were calculated for MSSA with cell volume 1.22 µm3, thickness 20 nm, turgor pressure 2 MPa, and septum relative stiffness 1.2. (B) Graphical representation of the changes in circumferential stress at the cell pole and equator as septum synthesis progresses. Here, septum progression is defined as (a − b)/a, where a is the cell radius and b is the septum aperture size, which decreases as the septum is formed (note that a and b are defined for the unpressurized cell; see Supplementary Information, Section II).

#MicrobiologyMonday: Staphylococcus aureus divides by building a septum and then splitting into 2 daughter cells. But how is septum formation coordinated with cell scission? Research in #mBio suggests cell wall mechanical stress could play a role: asm.social/2Eq

Host cell state: an overlooked factor impacting the production of influenza A deletion-containing viral genomes and non-infectious particles | mBio Within the infected host, influenza A virus has a bipartite existence as intracellular viral genomic segments undergoing replication and assembly into progeny particles and extracellular progeny parti...

New out in #mBio from our lab! Dr. Ile Agu reviewed developments on *host* influences on influenza deletion containing viral genomes (DelVGs, fka defective viral genomes).

Hoping for more research in this area. So much promising basic and applied science!
journals.asm.org/doi/10.1128/...
@asm.org

Gel of the initial cloned cagA product in λgt11 on 20 July 1989.

In #mBio, dive into story behind the 1989 discovery of Helicobacter pylori CagA, the first tumorigenic bacterial protein. This article recounts the early steps in the investigative process and relates some of the unexpected discoveries that ensued. asm.social/2C1

Microbes Without Borders: Uniting Societies for Climate Action

Microbes know no borders, nor should efforts to harness their potential for climate solutions. ASM & 9 other partners have launched a global strategy to position microbial science as a pillar of climate action.

🔗Read the press release & #mbio editorial: asm.org/climatestrat...

#ClimateAction

What an incredible week for @julielebris.bsky.social with one published ms in @asm.org #mBio on #capsule phenotypic heterogeneity & a preprint on the modular evolution of a highly exchangeable locus ⏩️capsule 😅
All her hard work is paying off!
#ProudPI
#microsky @klebclub.bsky.social
Check her 🧵👇🏻

Small-cap stocks registering bullish MACD crossover signals, Thu Sept 11th - #VERO #SANA #RELL #AZTA #BWEN #CMMB #DERM #FLL #IMUX #LVO #MBIO #UDMY #TRUG #PDY #NVTS #YRD #UTL #LBRT - More: crystalequityresearch.com/trade-alerts... - #smallcap

Evolution in response to prophage activation attenuates the virulence of culturable Serratia symbiotica relatives of aphid endosymbionts | mBio Laboratory experiments can be used to explore evolutionary innovations in how microbes associate with animal hosts. Serratia symbiotica bacteria exhibit a variety of interactions with aphids. Some strains are obligate endosymbionts. Others have ...

Evolution in response to prophage activation attenuates the virulence of culturable Serratia symbiotica relatives of aphid endosymbionts

#mBio by Anthony VanDieren & Jeff Barrick

journals.asm.org/doi/10.1128/...

Crosslinking mass spectrometry. (A) Schematic illustrating the overall process of crosslinking mass spectrometry used in this study. The chemical structure shown is that of azide-a-DSBSO, the crosslinker, which contains various functional groups highlighted by circles. (B) Interactome networks derived from crosslinking mass spectrometry analyzes of T. gondii cytosolic proteins. Each node represents a protein and is color-coded according to its subcellular localization, as determined by hyperLOPIT assignments. The edges are color-coded based on the confidence of identification (high: FDR < 1%; medium: 1% < FDR < 5%).

In #mBio, researchers present a novel application of crosslinking mass spec (XL-MS) integrated with machine learning to characterize cytosolic protein-protein interactions in T. gondii, offering a framework that can be applied to other microbial systems. asm.social/2A1

ASM figure pre-screening workflow can identify image duplication concerns using Imagetwin and address them before publication. (A) Image duplication represents two-thirds of figure-related concerns in post-acceptance manuscripts. (B) All image duplication concerns were resolved following our policies and procedures in accordance with ethical guidelines by modifying the figures and/or text. (C) Complex image duplication concerns were resolved through editorial consultations, which sometimes led to revoking acceptance decision for the manuscript.

Image duplication erodes trust in the peer review process. This #mBio article shares results from ASM Journals’ 2023 pilot program using Imagetwin, an image duplication screening tool, which is now a part of routine ethics checks performed by #ASMJournals: asm.social/2yQ

(p)ppGpp-dependent activation of gene expression during nutrient limitation | mBio Bacteria often experience nutrient limitation and, in response, attenuate energetically costly metabolic processes like protein synthesis. At the same time, however, they stimulate the expression of a subset of proteins that facilitate survival under ...

(p)ppGpp-dependent activation of gene expression during nutrient limitation

#mBio from Jonathan Dworkin

journals.asm.org/doi/10.1128/...

NEWS: ( NASDAQ: #MBIO ) Expected earnings - Mustang Bio Inc.

Pathogenic Leptospira spp. have lost their SOD

Roughly 10% of all living organisms lack superoxide scavenging enzymes (SOSEs). How do they survive superoxide stress? Research in #mBio suggests redox-based metabolic reprogramming may compensate for loss of SOSEs in pathogenic bacteria. Get the story: asm.social/2wV

Disulfide bonds are critical for stabilizing cell division, cell envelope biogenesis, and antibiotic resistance proteins in mycobacteria | mBio This work addresses a major deficiency in understanding mycobacterial cell envelope processes and highlights the biological and clinical implications of oxidative protein folding in mycobacteria. This...

Great collaboration with my Bloomington colleague @cris-s.bsky.social out now in #mbio #teammassspec journals.asm.org/doi/10.1128/...