New preprint @biorxiv-devbio.bsky.social by Harshath Amal and colleagues from our lab @uni-muenster.de shows how a BMP #morphogen gradient is translated into graded junctional permeability by tuning adhesion and actomyosin contractility in #Drosophila
See tinyurl.com/yhbwd9xh
@sfb1348.bsky.social
🎉 Congratulations to Leeya Engel & Alexander R. Dunn from @stanforduniversity.bsky.social 🏛️on their recent article published in @cp-iscience.bsky.social from @cellpress.bsky.social: “A #microfluidic platform for anterior–posterior human endoderm patterning via countervailing #morphogen gradients"
A summary schematic showing morphogen gradients in the developing human embryo, an overview of two screenings performed in the study (one testing factors related to patterning conditions, another one testing factors related to patterning reproducibility) and icons representing the main readouts of the screenings: organoid cell type composition, measures of morphogen interactions, primary atlas comparison and regulon activity.
Your new batch of cortical organoids resulted in mixed regional identities closer to hindbrain. Why is patterning so hard?😩
✨Our latest paper might help you✨
tinyurl.com/neorgpat
#morphogen #neuralorganoids #patterning #scRNAseq
@graycamplab.bsky.social @ethz.ch @nazbukina.bsky.social
James Briscoe on #morphogen #gradients and #optogenetic modifications in development #insdb2025 @insdb.bsky.social
