New preprint out!
In this study, we introduce NanoFLex, a strategy that combines #HaloTag variants with #nanobodies -based immunolabeling to enable rapid, OneStep-IF #lifetime #multiplexing. Possible due to SmartSecondaries fused to #HaloTag from @nanotag.bsky.social: www.biorxiv.org/content/10.6...

Heading to #BPS2026 in San Francisco?

Visit NanoTag team at booth 720 to explore our single-domain antibody #sdAb tools: ALFA® System, FluoTags®, Smart Secondaries® & Selector Resins.
See you! 👋

@biophysicalsoc.bsky.social
#Nanobody #Multiplexing
#SuperResolution #Microscopy
#AffinityPurification

#OET_highlight Parallel all-optical encoded CDMA-driven anti-interference LiDAR for 78 MHz point acquisition doi.org/10.29026/oet... by Prof. #Mingbo_Pu #Xiangang_Luo #IOE_CAS #parallel #LiDAR #code_division #multiple_access #wavelength_division #multiplexing
#interference

#MULTIPLEXING
multi-search-tag-explorer.aepiot.com/advanced-sea...
aepiot.ro

#OES_highlight Integrated metasurface-freeform system enabled multi-focal planes augmented reality display doi.org/10.29026/oes... by Prof. #Yongtian_Wang #Tong_Yang #Lingling_Huang @BIT1940 #augmented_reality #AR #metasurfaces #freeform #display #polarization #multiplexing

In telecommunications and computer networking, #multiplexing was a method by which multiple analog or digital signals were combined into one signal over a shared medium. The aim was to share a scarce resource—a physical transmission medium.

Join our CTO, Felipe Opazo @opazo.bsky.social, at #MBSJ2025 @mbsj-official.bsky.social as he presents new super-resolution #multiplexing advances powered by #SmartSecondaries®.
🔬Discover flexible, scalable and precise multi-target imaging.

#Nanobody
#NanoPlex #SUMPAINT
#SuperResolution #Microscopy

#Multiplexing #KLdivergence #Expensive #Brain #Hypothesis
Otto, A. R., Westbrook, A., & Daunizeau, J. (2025). Why is cognitive effort experienced as costly? Trends in Cognitive Sciences. Advance online publication. doi.org/10.1016/j.ti...

#OET_highlight Phase matching sampling algorithm for sampling rate reduction in time division multiplexing optical fiber sensor system doi.org/10.29026/oet... by Prof. #Zhilin_Xu #Qizhen_Sun @2024_HUST #multiplexing #algorithm #interferometric #fiber #optic #sensors
#array

💡Simplemux: boosting efficiency & reliability in #SmartGrids.

Developed under #ESTELARproject by Jose Saldana (Univ. Zaragoza–CIRCE), it’s a #multiplexing protocol improving #communication in digital substations through optimized traffic & low-latency delivery.

🔗 zenodo.org/records/1720...

Handle multiple data streams effortlessly with a fiber optic modem for multiplexing multiple serial data streams. Fast, secure, and stable connectivity.

Discover more: www.versitron.com/products/rs-...

#FiberOptic #SerialData #Multiplexing #Modem

We present a versatile microfluidics platform that makes multiplexed super-resolution imaging more accessible, reproducible, and high-throughput.

👉 BioRxiv: www.biorxiv.org/content/10.1...

#SuperResolution #DNApaint #Microfluidics #SMLM #OpenScience #multiplexing

🔬✨ #GEF25 Expansion Microscopy Forum in Göttingen just wrapped up! We were happy to support as sponsors and share our sdAb innovations for super-resolution #microscopy. Thanks to the organizers & all participants for an inspiring event! 👏

#ExM #SmartSecondaries #Multiplexing

🔬Wrapping up #SMLMS2025 @smlm-symposium.bsky.social in Bonn! Thanks to everyone who stopped by our booth!
It was great connecting and sharing how our #sdAb-based solutions enhance precision, simplify #Multiplexing, and streamline workflows in #SuperResolution microscopy.

See you next year! 🦙

🔬 Attending #SMLMS25 in Bonn?

Don’t miss our CSO Dr. Steffen Frey on Wednesday Aug 27, 14:40, presenting #SmartSecondaries® – secondary sdAb-based reagents enabling OneStep-IF and Species-Independent #Multiplexing.

🦙 Come by at the NanoTag booth for a chat!

#SuperResolution #Microscopy #Nanobody

The Summer School is almost here! 🔬 Samples ready, welcome kits prepared, vials aliquoted... we can’t wait to teach you all about Ribo-Seq Multiplexing 🤩 Are you ready? Learn more 👉 zurl.co/rpaHT

#RiboSeq #ribosome #multiplexing #summerschool

Empowering Nanoscopy with single-domain antibodies_NanoTag Biotechnologies_SMLM2025

🔬 Two weeks to go until the 14th #SMLM2025 @smlm-symposium.bsky.social! NanoTag joins as Gold Sponsor to support this unique #SuperResolution community event. Don't miss our CSO Dr. Steffen Frey talk on Smart Secondaries® (27 Aug, 14:40) or meet him at the #NanoTag booth 🦙. #Nanobody #Multiplexing

🎨 Precision and Molecular imaging need a broad palette. FluoTags® are fluorescent #sdAbs/ #nanobodies available in Alexa, Atto, AbberiorSTAR, JF635b, IRDyes & more for #Confocal, #STED, #STORM, and #NIR imaging. Custom dye? No ProbLama! nano-tag.com/shop/

#Microscopy #Nanobody #Multiplexing

🔬 Today at #mmc2025 we’re exploring the cutting edge of #ultramicrotomy and exploring #spatialbiology.
📍Workshop Room 1:
🕑10:15 – Precision sectioning redefined: ultramicrotomy in the digital age
🕑13:15 – SpectraPlex: overcoming the high #multiplexing barrier

Join us: https://fcld.ly/oj1w6ps

Change begins with curiosity! Join our #mmc2025 workshops & see how to:
✂️ Redefine precision sectioning w/ our new #ultramicrotome
🔬 Get higher quality data w/ THUNDER + #spinningdisk
✨ Overcome the high #multiplexing barrier w/ SpectraPlex for STELLARIS

Get reminders: https://fcld.ly/oj1w6ps

Next up in the #Adelaide #Bioinformatics Seminar series…

Nick Warnock (SA Path)
“Evaluating Cell Assignment Accuracy in #scRNA-Seq #Multiplexing”
Friday, June 20; 1:00–2:00ish

Drop in. Stay curious. Multiplex wisely.

Info here: doppeldata.au/events/event...

In telecommunications and computer networking, #multiplexing was a method by which multiple analog or digital signals were combined into one signal over a shared medium. The aim was to share a scarce resource—a physical transmission medium.

Nearly 200 tunnels in Norway are equipped with #WorldDABAuto25 Lunch sponsor #PanedaDAB's systems. Many broadcasters are using #Paneda DAB Head-End systems including #multiplexing, #audioencoders, #datainsertion and #contentmanagement. paneda.no #PanedaDAB #headend #endtoend #hardware

🤹‍♀️ Still juggling primary antibodies from different species?
Still stuck in sequential staining?

⏱️Switch to Smart Secondaries®🦙:
✅OneStep-IF
✅Same-species #multiplexing
✅Higher precision & reproducibility!

Choose smart 👉 bit.ly/3UZxRMI

#SecondaryNanobody #Microscopy #Immunofluorescence

@abberior.rocks — and NanoTag Biotechnologies rocks with them! 🤘

Smart Secondaries® 🦙now conjugated to abberior STAR dyes 🌈. Discover brighter, sharper, #STED -ready, species-independent #multiplexing & one-step IF. 🔬🤩

#SecondaryNanobodies
#SuperResolution
#FluorescenceMicroscopy

Und aktuell?
Wir sprechen gerade über die nächste Stufe:
Ein 17-plex – ohne Zyklisierung.
Das bedeutet: alle Marker gleichzeitig, ohne Zwischenschritte. Ambitioniert, aber extrem spannend.

#Forschung #Multiplexing #Organoide #Immunfluoreszenz #LehreUndLabor

Clever Engineering Leaves Appliance Useless Around these parts, we generally celebrate clever hacks that let you do more with less. So if somebody wrote in to tell us how they used multiplexing to drive the front panel of their latest gadget with fewer pins on the microcontroller than would normally be required, we’d be all over it. But what if that same hack ended up leading to a common failure in a piece of consumer hardware? As [Jim] recently found out, that’s precisely what seems to be ailing the Meaco Arete dehumidifier. When his stopped working, some Internet searching uncovered the cause of the failure: if a segment in the cheap LED display dies and shorts out, the multiplexing scheme used to interface with the front panel essentially reads that as a stuck button and causes the microcontroller to lock up. He passed the info along to us as a cautionary tale of how over-optimization can come with a hidden cost down the line. Judging by the thread from the _Badcaps_ forum, the problem was identified last summer. But unless you had this particular dehumidifier and went searching for it, it’s not the kind of thing that you’d otherwise run into. The users start by going through the normal diagnostic steps, but come up short (no pun intended). Given its simplicity, the front panel PCB was not an obvious failure point. Eventually, user [CG2] resorts to buzzing out all the connections to the two digit seven-segment LED display on the front panel, and finds a dead short on one of the segments. After removing the display, the dehumidifier sprung back to life and everything worked as expected. It wasn’t hard to identify a suitable replacement display on AliExpress, and swapping it out brought the appliance back up to full functionality. Now to be fair, a shorted out component is likely to cause havoc wherever it might be in the circuit, and as such perhaps it’s the lowest-bidder LED display with the unusually high failure rate that’s really to blame here. But it’s also more likely you’d interpret a dark display as a symptom of the problem rather than the cause, making this a particularly tricky failure to identify. In any event, judging by how many people seem to be having the same problem, and the fact that there’s now an iFixit guide on how to replace the shorted display, it seems like this particular product was cost-optimized just a bit too far.

Clever Engineering Leaves Appliance Useless Around these parts, we generally celebrate clever hac...

hackaday.com/2025/04/10/clever-engine...

#Repair #Hacks #LED #display #multiplexing #optimization #short #circuit

Event Attributes

Clever Engineering Leaves Appliance Useless Around these parts, we generally celebrate clever hacks that let you do more with less. So if somebody wrote in to tell us how they used multiplexing to drive the front panel of their latest gadget with fewer pins on the microcontroller than would normally be required, we’d be all over it. But what if that same hack ended up leading to a common failure in a piece of consumer hardware? As [Jim] recently found out, that’s precisely what seems to be ailing the Meaco Arete dehumidifier. When his stopped working, some Internet searching uncovered the cause of the failure: if a segment in the cheap LED display dies and shorts out, the multiplexing scheme used to interface with the front panel essentially reads that as a stuck button and causes the microcontroller to lock up. He passed the info along to us as a cautionary tale of how over-optimization can come with a hidden cost down the line. Judging by the thread from the _Badcaps_ forum, the problem was identified last summer. But unless you had this particular dehumidifier and went searching for it, it’s not the kind of thing that you’d otherwise run into. The users start by going through the normal diagnostic steps, but come up short (no pun intended). Given its simplicity, the front panel PCB was not an obvious failure point. Eventually, user [CG2] resorts to buzzing out all the connections to the two digit seven-segment LED display on the front panel, and finds a dead short on one of the segments. After removing the display, the dehumidifier sprung back to life and everything worked as expected. It wasn’t hard to identify a suitable replacement display on AliExpress, and swapping it out brought the appliance back up to full functionality. Now to be fair, a shorted out component is likely to cause havoc wherever it might be in the circuit, and as such perhaps it’s the lowest-bidder LED display with the unusually high failure rate that’s really to blame here. But it’s also more likely you’d interpret a dark display as a symptom of the problem rather than the cause, making this a particularly tricky failure to identify. In any event, judging by how many people seem to be having the same problem, and the fact that there’s now an iFixit guide on how to replace the shorted display, it seems like this particular product was cost-optimized just a bit too far.

Clever Engineering Leaves Appliance Useless Around these parts, we generally celebrate clever hac...

hackaday.com/2025/04/10/clever-engine...

#Repair #Hacks #LED #display #multiplexing #optimization #short #circuit

Event Attributes

Clever Engineering Leaves Appliance Useless Around these parts, we generally celebrate clever hacks that let you do more with less. So if somebody wrote in to tell us how they used multiplexing to drive the front panel of their latest gadget with fewer pins on the microcontroller than would normally be required, we’d be all over it. But what if that same hack ended up leading to a common failure in a piece of consumer hardware? As [Jim] recently found out, that’s precisely what seems to be ailing the Meaco Arete dehumidifier. When his stopped working, some Internet searching uncovered the cause of the failure: if a segment in the cheap LED display dies and shorts out, the multiplexing scheme used to interface with the front panel essentially reads that as a stuck button and causes the microcontroller to lock up. He passed the info along to us as a cautionary tale of how over-optimization can come with a hidden cost down the line. Judging by the thread from the _Badcaps_ forum, the problem was identified last summer. But unless you had this particular dehumidifier and went searching for it, it’s not the kind of thing that you’d otherwise run into. The users start by going through the normal diagnostic steps, but come up short (no pun intended). Given its simplicity, the front panel PCB was not an obvious failure point. Eventually, user [CG2] resorts to buzzing out all the connections to the two digit seven-segment LED display on the front panel, and finds a dead short on one of the segments. After removing the display, the dehumidifier sprung back to life and everything worked as expected. It wasn’t hard to identify a suitable replacement display on AliExpress, and swapping it out brought the appliance back up to full functionality. Now to be fair, a shorted out component is likely to cause havoc wherever it might be in the circuit, and as such perhaps it’s the lowest-bidder LED display with the unusually high failure rate that’s really to blame here. But it’s also more likely you’d interpret a dark display as a symptom of the problem rather than the cause, making this a particularly tricky failure to identify. In any event, judging by how many people seem to be having the same problem, and the fact that there’s now an iFixit guide on how to replace the shorted display, it seems like this particular product was cost-optimized just a bit too far.

Clever Engineering Leaves Appliance Useless Around these parts, we generally celebrate clever hac...

hackaday.com/2025/04/10/clever-engine...

#Repair #Hacks #LED #display #multiplexing #optimization #short #circuit

Event Attributes

Thanks to everyone who visited our booth at the #GöttingenMeeting! 🧠
Great to connect with so many passionate researchers.
Inspiring talks, spring sunshine, and cherry blossoms 🌸 — the perfect setting to share our sdAb tools.🦙🔬
#Nanobody #Microscopy #Multiplexing #SmartSecondaries #ALFAtag #NWG2025