Accelerating enzyme discovery and engineering with high-throughput screening Covering: up to August 2024 Enzymes play an essential role in synthesizing value-added chemicals with high specificity and selectivity. Since enzymes utilize substrates derived from renewable…

🔓Check out the #OpenAccess review by @pabnik.bsky.social & co. @labnikel.bsky.social in our latest issue exploring emergent strategies and methods for isolating, creating & characterizing enzymes optimized for bioproduction #natprod

Read in full on our website🔽

Enhanced Absorption and Product Labeling A Student Assignment

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#Plant #secmet #natprod #ChemSky

The Ugi–Joullié three-component reaction (UJ-3CR) and related reactions: recent developments, mechanistic aspects and synthesis of natural products and bioactive compounds The Ugi–Joullié three-component reaction evolved from the classic Ugi four-component reaction and enables the facile and efficient formation of polysubstituted nitrogen heterocycles from cyclic…

Don't miss this review in our latest issue by Teodoro Kaufman et al. from Universidad Nacional de Rosario looking at recent developments and mechanistic insights of the Ugi–Joullié three-component reaction #orgchem #natprod

Check it out in full here🔽

📢Our latest issue is now online!

Check out the paper behind the cover from Guidong Lu, Minshou Wang, Shizhi Jiang & co. at Dali University describing the synthesis of a series of novel meroterpenoid natural products #orgchem #natprod

pubs.rsc.org/en/content/a...

🎉We are delighted to announce that the 2026 Natural Product Reports Emerging Investigator Lectureship has been awarded to Jakob Franke (@unihannover.bsky.social)

Please join us in congratulating him! #chemsky #natprod #secmet

Read more about Jakob and his research🔽
blogs.rsc.org/np/2026/03/1...

Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we…

🔓Take a look in our latest issue at this #OpenAccess review by Stephanie Heard & Alessandra Eustaquio @eustaquiolab.bsky.social looking at the development of Burkholderia bacteria as heterologous hosts #natprod #secmet

📍 @uofilsystem.bsky.social
pubs.rsc.org/en/content/a...

Ashwagandha Dosing, Part II: Rethinking Dose

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#Plant #secmet #natprod #ChemSky

Ashwagandha Dosing, Part I Is the evidence insufficient?

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#Plant #secmet #natprod #ChemSky

Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering Covering: up to 2025. Non-ribosomal peptide synthetases and polyketide synthases are modular biosynthetic systems that produce structurally diverse and pharmacologically potent natural products,…

Be sure to read this review by Kenan Bozhüyük & co. @helmholtzhips.bsky.social highlighting the tools and strategies for NRPS and PKS pathway exploration and engineering in our latest issue #natprod #secmet

Find the full article below👇

🔓Don't miss the #OpenAccess Highlight behind the cover of our latest issue by Francesco Del Carratore & Rainer Breitling @liverpooluni.bsky.social & @manchester.ac.uk on how microbiomes can be engineered for natural product discovery and production #secmet #natprod

pubs.rsc.org/en/content/a...

Fermentation as an Extraction Method Recovering Traditional Techniques for Today's Herbal Product Needs

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#Plant #secmet #natprod #ChemSky

Does Changing Form Alter the Clinical Uses of Medicinal Plants Red Clover Extraction, Stability, Absorption, and Clinical Endpoint

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#Plant #secmet #natprod #ChemSky

📢Our latest issue is now online!

This month's issue is a special themed collection on Microbial Host & Metabolic Engineering for Natural Product Discovery & Production #secmet #natprod #chemsky

Read the articles in the collection on our website here🔽
pubs.rsc.org/en/journals/...

Overview of the paper in cartoon form

We are delighted to share our vision in #RSCChemBioy of how to incorporate natural product discovery (and any drug discovery) into the framework of personalized medicine - drug discovery using patients, but not in patients! #natprod #secmet pubs.rsc.org/en/content/a...

Engineering class I terpene synthases for skeletal diversity: strategies and applications Covering: up to August 2025 Terpenoids constitute nature's largest and most structurally diverse class of natural products, with extensive applications in medicine, agriculture, and fragrance…

Don't miss a review by Liao-Bin Dong & co. at the China Pharmaceutical University in our latest issue examining the strategies and applications for engineering class I terpene synthases for skeletal diversity #natprod #secmet

Check out the full article on our website🔽

An integrative chemical and genomic similarity approach linking fungal secondary metabolites and biosynthetic gene clusters Fungi are well known to biosynthesize structurally complex secondary metabolites (SMs) with diverse bioactivities. These fungal SMs are frequently produced by biosynthetic gene clusters (BGCs).…

Read in our latest issue a paper by @rokaslab.bsky.social & co. from @vanderbilt.edu & @uncg.edu describing an integrative chemical & genomic similarity approach to link fungal secondary metabolites & biosynthetic gene clusters #natprod #secmet

Find it in full here🔽

Glycosylated mycotoxins: a hidden enemy Covering: 2010 up to 2025 (May) Mycotoxins, secondary metabolites produced by filamentous fungi, are highly toxic contaminants of food crops. These contaminated plants pose a significant health risk…

🔓Check out this #OpenAccess review in our latest issue by Vladimír Křen & co. @vschtpraha.bsky.social & @mbuavcr.bsky.social summarising the formation and occurrence of glycosylated mycotoxins and their transformations in the food chain #natprod

Read it in full here👇

#natprod

Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis Covering: up to 2025 Cardiac glycosides (CGs), a class of metabolites found in nature, comprise sugar residues, unsaturated lactone rings, and steroidal cores. As renowned phytotoxins, they play…

Take a look at a review by Shuang Liu, Ping Su, Luqi Huang & co. in our latest issue providing an overview of the structural diversity, chemical ecology, bioactivity & artificial synthesis of cardiac glycosides #natprod #secmet

📍China Academy of Chinese Medical Sciences

Progress, challenges, and opportunities in the field of biosynthetic reactions involving ambimodal transition states Covering: up to June 2025 High selectivity is generally observed in the biosynthesis of complex natural molecules. Evolution usually leads to enzymes that favor the formation of a particular isomer…

Be sure to read this Highlight from Hidayat Hussain & co. at @uclacb.bsky.social & @ljmuofficial.bsky.social discussing the progress, challenges & opportunities in the field of biosynthetic reactions involving ambimodal transition states #natprod

Find in full here🔽

In our latest preprint we report the unexpected discovery of Epi-STR, an R-stereoselective ortholog of the S-selective canonical Strictosidine synthases (STRs). Found in the rather obscure plant Pogonopus specious. This work was led by my stellar student Clara Morweiser!
#natprod
#PlantScience

Fermentation Scientist I Job Opening: Fermentation Scientist I at Bactobio in London.

We're looking for a Fermentation Scientist to help scale up production of our bioactive metabolites. If you've got experience with secondary metabolites, bioreactors, and culture condition optimisation give it a look! #secmet #natprod bactobio.pinpointhq.com/en/postings/...

Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis Covering: 1948 to 2025 Ryanodane diterpenes (RDs) are a unique class of plant-derived natural products characterized by their complex, polyoxygenated pentacyclic frameworks. They have been primarily…

Don't miss this review in our latest issue by Yu Zhang et al. from the Kunming Institute of Botany looking at the occurrence, structural diversity, bioactivities and synthesis of ryanodane diterpenes #natprod #secmet

Check out the full article below👇

📢Our annual Marine Natural Reports review is in our latest issue and #OpenAccess! #chemsky #natprod #secmet

A big thank you to the authors:
Tony Carroll, Brent Copp, Tanja Grkovic, Robert Keyzers & Michèle Prinsep

Read their coverage of the 2024 MNP literature here🔽
pubs.rsc.org/en/content/a...

🎉We are delighted to welcome @kelloggnpgroup.bsky.social, @kateduncan.bsky.social & Yihua Chen to the @natprodreports.rsc.org Editorial Board! #natprod #secmet

Learn more about our new Editorial Board members here🔽
blogs.rsc.org/np/2026/01/3...

#natprod

📢Our first issue of 2026 is now online!

Check out the review behind the cover by Mark Butler, Robert Capon & co. at the University of Queensland covering natural product-derived compounds in clinical trials & drug approvals from 2014-2024 #natprod #secmet #medchem

pubs.rsc.org/en/content/a...

Synthesis-enabled conformational assignment of natural N-acyl L-phenylalanine derivatives from freshwater sponge–associated Micromonospora sp. MS-62 This study demonstrates a concise four-step total synthesis of N-acyl-l-phenylalanine derivatives (P1–P5) from Micromonospora sp. MS-62 enabling definitive assignment of the S configuration at C-1′…

Take a look in our latest issue at research from Ja Young Cho, Taejung Kim & co. reporting the synthesis-enabled conformational assignment of natural N-acyl l-phenylalanine derivatives from freshwater sponge–associated Micromonospora sp. MS-62 #natprod #orgchem

📍KIST

Rotenoid diversity, distribution and evolution in plant lineages Covering upto 2025 Rotenoids are angular hybrid isoflavonoids mainly characterized by an additional six-membered ring between the B and C rings of flavonoids. The extra ring introduces further…

Read this Highlight in our latest issue by Vaderament-A. Nchiozem-Ngnitedem, Gabin Thierry M. Bitchagno et al. from @unipotsdam.bsky.social & @rbgkew.bsky.social discussing Rotenoid diversity, distribution and evolution in plant lineages #natprod

Find in full here👇

Don't miss your chance to present your research at Directing Biosynthesis VIII!

⏳Time is running out until the oral abstract deadline on the 2nd of February▶️ rsc.li/dbviii

Be sure to join us and the rest of the #Biosynthesis community in Manchester this summer

#natprod #secmet #DBVIII