This study provides robust evidence that mid-term, multi-setting indoor air-purification can significantly enhance cognitive health in children in areas with high air pollution levels.
doi.org/10.1016/j.xi...
#PM2point5 #CognitiveHealth #randomizedcontrolledtrial

Synapse: Your Connection to our MSK Authors
Meet: Andrea Cameron Marie Smith
Research Focus: Nursing; Nurse Leader

Oral self-management of palbociclib using mobile technology: Findings from a nurse-led randomized controlled trial

synapse.mskcc.org/synapse/work...
#RandomizedControlledTrial

A new diet option for mild-to-moderate Crohn’s disease – BioNews Central A national, randomized controlled clinical trial found that a short-term, calorie-restrictive diet significantly improved both physical symptoms and biological indicators of mild-to-moderate Crohn’s disease. ...

A national, #RandomizedControlledTrial found that a short-term, #CalorieRestrictiveDiet significantly improved both physical symptoms and biological indicators of mild-to-moderate #CrohnsDisease.
#InflammatoryBowelDisease #Fasting #FastingMimickingDiet

Mobile-Based Ecological Momentary Intervention for Improving Physical Activity in Adults Without Regular Physical Activity: Pilot Randomized Controlled Trial Background: The ecological momentary intervention (EMI) is one of the most promising digital—primarily mobile—interventions to enhance physical activity (PA) and other health behaviors. It is a combination of ecological momentary assessment (EMA), in which participants are prompted to indicate their momentary states and ongoing behaviors in daily life, and the just-in-time delivery of interventions tailored to the EMA responses. The EMI has typically been implemented in message-based interventions (e.g., activity recommendations tailored to users’ physical locations), but its efficacy and #feasibility have not been sufficiently established because of the variability in design and implementation. Objective: This pilot, two-arm, parallel-group randomized controlled trial aimed to be an exemplar of EMI for improving PA and establish efficacy and #feasibility among adults without a habit of PA. Methods: Forty participants (23 women; mean age=45.40, SD=10.50) were recruited from among community dwellers in northeast Japan and randomly allocated to the EMI or control group. Each participant wore an activity tracker to monitor their daily step count and heart rate for four weeks (fully automated). Simultaneously, they responded to EMA questions about the current weather, location, and social context three times during the daytime and an additional evening question about motivations for PA each day. Only the EMI group received messages tailored to their responses to EMA, recommending more active alternative behaviors suited to EMA-reported contexts. Results: Participants wore a Fitbit device for 90.3% (21.66/24 hours per day) of the study period (SD = 10.0), and no dropouts were observed. The EMI group showed no significant improvement in the self-reported amount of PA (P=.444), step count (P=.239), or motivation for PA (P>.105) compared with the control group. However, the EMI group showed a significantly larger increase in the minutes of 40% heart rate reserve, a measure of moderate or high intensity of PA (M=16.033, 95% CI [3.758, 28.292], P=.017; Cohen’s d=0.20–0.41 for the follow-up weeks). The intervention was rated as marginally useful and satisfactory, and approximately half of the participants expressed a willingness to continue the intervention. The timing of the EMA prompting was considered inappropriate. Conclusions: These findings suggest that the EMI with messages tailored to EMA-reported contexts was not effective in increasing the amount or motivation for PA but may increase the intensity as assessed by the heart rate. The intervention aimed to help individuals implement small but slightly more active behaviors in their daily routine, which may not accompany prominent body movements but may be reflected in the increased heart rate. Marginal #feasibility indicates that the intervention has sufficient scope for improvement, particularly in terms of the prompt timing. Clinical Trial: OSFosf.io/nzkyf; https://osf.io/nzkyf/?view_only=e23804b941dd4843a3ba0902e51fec20

JMIR Formative Res: Mobile-Based Ecological Momentary Intervention for Improving Physical Activity in Adults Without Regular Physical Activity: Pilot Randomized Controlled Trial #PhysicalActivity #EcologicalMomentaryIntervention #HealthBehavior #RandomizedControlledTrial #DigitalHealth

Combination inhaler reduces asthma attacks in children by almost half – BioNews Central Findings from a randomized controlled trial comparing the real-world effectiveness of asthma inhalers could reshape treatment for children with asthma.

Findings from a #RandomizedControlledTrial comparing the real-world effectiveness of #AsthmaInhalers could reshape treatment for #children with #asthma.
#CombinationTreatment #AsthmaTreatment

Increasing legumes and cutting red/processed meat boosts men’s health – BioNews Central A 6-week randomized controlled trial in healthy, working-age men found that partially replacing red and processed meat with legume-based foods reduced total and “bad” (LDL) cholesterol and led to weight loss. ...

A 6-week #RandomizedControlledTrial in healthy, working-age #men found that partially replacing red and #ProcessedMeat with #LegumeBasedFood reduced total and “bad” #LDLCholesterol and led to #WeightLoss.
#RedMeat #Legumes #MensHealth

#feasibility of a Randomized Controlled Trial of Large AI-Based Linguistic Models for Clinical Reasoning Training of Physical Therapy Students: Pilot Randomized Parallel-Group Study Background: Clinical reasoning is a critical skill for physical therapists, involving the collection and interpretation of patient information to form accurate diagnoses. Traditional training often lacks the diversity of clinical cases necessary for students to develop these skills comprehensively. Large Language Models (LLMs) like GPT-4 have the potential to simulate a wide range of clinical scenarios, offering a novel approach to enhance clinical reasoning in physical therapy education. Objective: The aim of this study is to explore the main barriers and facilitators that could be encountered in conducting a randomised clinical trial to study the effectiveness of the implementation of LLM models as tools to work on the clinical reasoning of physiotherapy students. Methods: This pilot randomized parallel-group study involved 46 third-year physiotherapy students at La Salle Centre for Higher University Studies. Participants were randomly assigned to either the experimental group, which received LLM training, or the control group, which followed the usual curriculum. The intervention lasted for four weeks, during which the experimental group used LLM to solve weekly clinical cases. Digital competences, satisfaction, and costs were evaluated in order to explore the #feasibility of this intervention. Results: The recruitment and participation rates were high, but active engagement with the LLM was low, with only 5.75% of the experimental group actively using the model. No significant difference in overall satisfaction was found between the groups and the cost analysis reflected an initial cost of 460€ for completing the study. Conclusions: While LLMs have the potential to enhance specific digital competences in physical therapy students, their practical integration into the curriculum faces challenges. Future studies should focus on improving student engagement with LLMs and extending the training period to maximize benefits.

JMIR Formative Res: #feasibility of a Randomized Controlled Trial of Large AI-Based Linguistic Models for Clinical Reasoning Training of Physical Therapy Students: Pilot Randomized Parallel-Group Study #ClinicalReasoning #PhysicalTherapy #Education #HealthcareInnovation #RandomizedControlledTrial

An empirical study on the effect of PNF training on the recovery of patients with medial collateral ligament injury:Randomized controlled trial
Li, M., CHU, R., Peng, Y. et al.
Paper
Details
#PNFTraining #MCLInjuryRecovery #RandomizedControlledTrial

Breakthrough Study Reveals New Approach to Bacterial Vaginosis: Male Partner Treatment Recent findings from a groundbreaking randomized controlled trial in Australia have highlighted an innovative approach to tackling bacterial vaginosis (BV) by including antibiotic treatment for male partners. Published in the New England Journal of Medicine, this study suggests that such treatment significantly lowers the recurrence of BV in women. Key Insights from the Trial The trial, which was halted early due to promising results, demonstrated that women who received first-line antibiotics alongside their male partners—who also underwent topical and oral antibiotic treatment—experienced a 50% reduction in BV recurrence compared to women who were treated alone.

READ FULL ARTICLE ON MEN'S HEALTH: #BacterialVaginosis #BV #AntibioticTreatment #MalePartners #RandomizedControlledTrial #NewEnglandJournalOfMedicine #VaginalMicrobiome #HealthCare #SexualHealth #PreventionStrategies #TreatmentApproach #WomensHealth #DrCatrionaBradshaw #Guidelines #ClinicalResearch

Research Article

Patient Profiles in Randomized Controlled Trials Versus a Real-World Study in Psoriatic Arthritis: Scoping Review and Metaanalysis

📖 www.jrheum.org/cgi/content/...

#psoriaticarthritis #randomizedcontrolledtrial #registries

Prochlorperazine maleate versus placebo for the prevention of acute mountain sickness: study protocol for a randomized controlled trial - Trials Background Acute mountain sickness (AMS) is a debilitating condition that individuals may develop on ascent to high altitude. It is characterized by headache, nausea, vomiting, dizziness, and fatigue ...

👏Very proud of @cuanschutz.bsky.social faculty, Dr. Elan Small #emergencymedicine, on his first protocol paper to #Trials.

Elan led a #randomizedcontrolledtrial of compazine vs. placebo to prevent Acute Mountain Sickness. Results soon. Congrats!

trialsjournal.biomedcentral.com/articles/10....