With the technology available today -it's easy to #sequence #millions of #TCRs/T cells....time has come to in the same way to find #specificities for these #TCRs.... no reason not to do it!

Discovery of rare antigen-specific TCRs via replicate profiling Development of effective vaccines and targeted immunotherapies for cancer, autoimmunity, allergy, and infectious diseases requires comprehensive understanding of functionality and antigenic specificit...

I #AGREE "Functional characterization and transcriptomic mapping of T cells remain #incomplete without knowledge of their #clonal #antigenic #specificities. www.biorxiv.org/content/10.1...