Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere. New review from Angela C. Greenman, Willem de Lange, and J. Carter Ralphe @wiscpediatrics.bsky.social: rupress.org/jgp/article/...

#CardiacMuscle #Contraction #CellMotility #Biophysics

AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic #bradycardia. New study from Luca M.G. Palloni, Dario DiFrancesco and colleagues (University of Milano): rupress.org/jgp/article/...

#MolecularPhysiology #CellularPhysiology #CardiacMuscle #SignalTransduction

A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations. New review from Anthony Hessel @hesselanthony.bsky.social, Christopher Rand @crand22.bsky.social, Khoi Nguyen and colleagues: rupress.org/jgp/article/...

#Myofilaments #SkeletalMuscle #CardiacMuscle

Review @jgp.org: @hesselanthony.bsky.social @crand22.bsky.social, Nguyen et al. provide useful tips and tricks for all those beginning their journey into permeabilized muscle fiber mechanics. rupress.org/jgp/article/...

#Myofilaments #SkeletalMuscle #CardiacMuscle

Review: @hesselanthony.bsky.social @crand22.bsky.social, Nguyen et al. provide useful tips and tricks for all those beginning their journey into permeabilized muscle fiber mechanics. rupress.org/jgp/article/...

#Myofilaments #SkeletalMuscle #CardiacMuscle

Allosteric coupling of RyR calcium channels. Is it relevant to the [patho]physiology of heart and muscle? New review from Eduardo Rios (Rush University): rupress.org/jgp/article/...

#CardiacMuscle #SkeletalMuscle #ComputationalBiology #Biophysics

In @jgp.org: Eduardo Rios reviews the relevance for physiology and pathophysiology of the synchronous gating of sarco-endoplasmic reticulum Ca²⁺ release channels, reported in bilayer reconstitution experiments. rupress.org/jgp/article/...

#Biophysics #CardiacMuscle #ComputationalBiology

Eduardo Rios reviews the relevance for physiology and pathophysiology of the synchronous gating of sarco-endoplasmic reticulum Ca²⁺ release channels, reported in bilayer reconstitution experiments. rupress.org/jgp/article/...

#Biophysics #CardiacMuscle #ComputationalBiology #SkeletalMuscle

Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility, say Alejandro Alvarez-Arce, David Barefield @barefieldlab.bsky.social and colleagues @loyolachicago.bsky.social: rupress.org/jgp/article/...

#Myofilaments #CardiacMuscle

Regulation of voltage-sensing structures of Caᵥ1.2 calcium channel by the auxiliary β3-subunit. New study from Daniela De Giorgis, Guido Mellado, Jose Antonio Garate, and Alan Neely (Universidad de Valparaíso): rupress.org/jgp/article/...

#Biophysics #CardiacMuscle #MembraneTransport #IonChannels

Variability in reported midpoints of (in)activation of cardiac Ina. New study from Michael Clerx @michaelclerx.com, Paul Volders, and Gary Mirams @mirams.bsky.social @uniofnottingham.bsky.social: rupress.org/jgp/article/...

#ComputationalBiology #CardiacMuscle #CellularPhysiology #IonChannels

Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affects ß-cardiac myosin activity, say Matvey Pilagov, Sonette Steczina, Ateeqa Naim, Neil Kad and colleagues @kent.ac.uk: rupress.org/jgp/article/...

#Myofilaments #CardiacMuscle

Comparative mechanistic analysis of danicamtiv and omecamtiv mecarbil's in vivo cardiac effects. New study from Joshua Holmes and Julian Stelzer (Case Western Reserve University): rupress.org/jgp/article/...

#CardiacMuscle #Contraction #CellMotility #HeartFailure

Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes, say Kerry McDonald and colleagues: rupress.org/jgp/article/...

#CardiacMuscle #Myofilaments #Contraction #CellMotility #Biophysics

Regulation of loaded sarcomere shortening: McDonald et al. @Mizzou show that cardiac myosin binding protein-C regulates sarcomere-loaded shortening, especially at high loads, seemingly, by modulating cross-bridge availability rupress.org/jgp/article/...

#CardiacMuscle #Myofilaments

Marfan-syndrome cardiomyocytes show excess of #titin isoform N2BA and extended sarcomeric M-band, say Dalma Kellermayer, Cristina Șulea, Miklós Kellermayer, Balázs Kiss and colleagues: rupress.org/jgp/article/...

#CardiacMuscle #Contraction #Myofilaments

Novel Ca²⁺ wave mechanisms in cardiac myocytes revealed by multiscale Ca²⁺ release model, report Morris Vysma, James Welsh, and Derek Laver @uni-newcastle.bsky.social: rupress.org/jgp/article/...

#CardiacMuscle #ComputationalBiology #Biophysics #IntercellularSignaling

Vysma, Welsh, and Laver @uni-newcastle.bsky.social develop a Ca²⁺ release model that reproduces store load–dependent release and Ca²⁺ waves in skinned ventricular myocytes. rupress.org/jgp/article/...

#Biophysics #CardiacMuscle #ComputationalBiology #IntercellularSignaling

New review: Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease. From Maya Noureddine, Fiyaz Mohammed and colleagues: https://buff.ly/4jKxZtj

#ComputationalBiology #ProteinStructure #CardiacMuscle #Myofilaments

New: Tuan Phan and Daniel Fitzsimons @uidaho.bsky.social have created a mathematical model to provide a better understanding of the contribution of contractile and regulatory proteins to the regulation of contraction of mammalian cardiac muscle. https://buff.ly/4h81HqH
#CardiacMuscle #Contraction