Research topics include:
#EvoDevo #DevelopmentalBiology #Genomics #Genetics #Physiology #FunctionalGenomics #SingleCell #ComparativeGenomics #Regeneration #Aging #Neurobiology #DiseaseModels #HostMicrobe #Immunology #StemCells #CellBiology #CRISPR #GeneRegulation #Epigenomics #Metabolism #Evolution
Thanks to our #ComparativeGenomics team!
Special thanks to our instructors @sedlazeck.bsky.social & Ingo Ebersberger and this great group of attendees!
We wish you all the best with your projects and data!
Today we kicked off the #ComparativeGenomics course with @sedlazeck.bsky.social & Ingo Ebersberger!
On Day 1, we’re covering de novo assembly strategies, best practices, and quality control for genome assemblies.
Last seats available! 🚨
Join our #ComparativeGenomics course with @sedlazeck.bsky.social & @Ingo Ebersberger and learn how to analyse, compare, and interpret genomes using modern bioinformatics approaches. Don’t miss it—registration is closing soon!
@nanoporetech.com @pacbio.bsky.social
We further unexpectedly uncover a highly sporadic/hidden composite anti-invader system that integrates BREX with HerA/FtsK and Dpd modules. #BREXarchitecture #Comparativegenomics
The next edition of our #ComparativeGenomics course is just around the corner (📅 23–27 February)!
A few seats are still available — don’t miss the opportunity to learn comparative #genomics from Ingo Ebersberger & @sedlazeck.bsky.social 🚀
🔗 www.physalia-courses.org/courses-work...
#TEsky #TEworldwide #Transposons #Bioinformatics #Bioconda #GenomeAnnotation #TransposableElements #Genomics #ComparativeGenomics
🚨Last chance! Submit an abstract to #Fungal26 by tomorrow, December 4: buff.ly/1AMwJhf
They can cover an array of topics including #ComparativeGenomics #FunctionalGenomics #Pathogenic #GeneRegulation #CellBiology #Biochemistry #Metabolism #FungalEcology #Evo #DevelopmentalBio #PopGen and more.
This year's new intake of @mmbdtp.bsky.social students are enjoying getting stuck into @gemma-langridge.bsky.social's #comparativegenomics for week 4 of their bioinformatics training, with a couple of the #OG students @nisbetalice.bsky.social & @eh-hayles.bsky.social assisting!🧵1/3
Join our online #ComparativeGenomics course with Ingo & @sedlazeck.bsky.social , 23-27 Feb 2026! Learn genome assembly, variant detection (SNVs & SVs), and functional impact analysis with hands-on sessions.
www.physalia-courses.org/courses-work...
#Bioinformatics #Genomics
Our paper synthesizing discussions from the @embo.org lecture course on Evolutionary and Comparative #Genomics in now out @bioinfoadv.bsky.social
#ComparativeGenomics #GenomeEvolution
Join our online course on Sex Chromosome Evolution (6–10 Oct) with @astridboehne.bsky.social & @idarolti.bsky.social to gain hands-on experience in genomic and transcriptomic analyses.
www.physalia-courses.org/courses-work...
#SexChromosomes #GenomeEvolution #Transcriptomics #ComparativeGenomics
The RE protein family, defined by DUF3411, is exclusive to plastid-containing organisms. This suggests an early evolutionary origin, potentially concurrent with the establishment of primary endosymbiosis. 🌍 #EvolutionaryBiology #ComparativeGenomics
Schematic depiction of chick and mouse embryo heads at HH13 and E9.5, respectively. UMAP dimensionality reduction showing the overlap of mouse and chick neural crest cells, as well as the cell type based clustering and annotation.
#DBfeature 🐣
Stage‑matched scRNA‑seq uncovers a “trailblazer” gene network shared between mouse and chick, driving neural crest migration into craniofacial arches.
by J.A. Morrison et al.
www.sciencedirect.com/science/arti...
#EvoDevo #ComparativeGenomics #SingleCell
This work opens the door to:
1. Better microbial ecology models
2. Engineering beneficial microbes
3. Identifying new virulence or symbiosis factors
Read the preprint & share your thoughts!
#Microbiome #ComparativeGenomics #HostMicrob #PlantMicrobiome #Bioinformatics
www.biorxiv.org/content/10.1...
A human-specific mutation weakens FasL, a key immune weapon against solid tumors. Blocking plasmin or shielding FasL restores cancer-fighting power. Evolution may have traded resilience for complexity. #CancerResearch #Immunotherapy #HumanEvolution #ComparativeGenomics
🚀 Mini-symposium at JOBIM 2025: Biodiversity Genomics
Join us on July 10 in Bordeaux to explore how large-scale sequencing projects are reshaping comparative genomics and our understanding of biodiversity.
www.atlasea.fr/mini-symposi...
#Genomics #Biodiversity #ComparativeGenomics #JOBIM2025
Our @nisbetalice.bsky.social, @emmabeansworth.bsky.social & @gemma-langridge.bsky.social are having a magnifique time at #I3S. Currently they are enjoying talks in the #comparativegenomics session where Emma will also present her poster (102) showing genome rearrangement can impact #virulence & #AMR
🐢Slow & steady strides to decoding longevity!🐢
Dovetail’s Omni-C tech helped scaffold T2T genomes of 2 tortoises, including Jonathan—the world’s oldest land animal (192 yrs).
Enabling:
-Structural variant mapping
-Repeat/telomere placement
-Context for methylation/expression
#ComparativeGenomics
(2/3) 🌍 By sequencing the genomes of over 240 mammalian species, scientists can identify conserved genes — the ancient, unchanging parts of DNA that reveal what’s truly essential for life. 🧬
#ZoonomiaProject #ComparativeGenomics #Evolution #GenomeScience #Biodiversity #HumanHealth #Conservation
(1/3) 🌍 EBP’s Zoonomia Project (zoonomiaproject.org) is transforming how we understand both biodiversity and human health!
#Zoonomia #Science Article 2023:
www.science.org/doi/10.1126/...
www.sciencenews.org/article/find...
#ComparativeGenomics #ZoonomiaProject #Evolution #Conservation
Phylogenetic tree structure of S. Paratyphi A, Typhi and Typhimurium representative isolates.
Delighted to share our latest scientific article (doi.org/10.1080/2150...) about #comparativegenomics of #Salmonella enterica serovars Paratyphi A, Typhi and Typhimurium reveals distinct profiles of their #pangenome, mobile genetic elements, #antimicrobialresistance and defense systems repertoire.
NCBI’s new Comparative Genome Viewer is seriously cool!
Using our tropical abalone genome assembly www.nature.com/articles/s41..., you can now explore synteny, structural variation & gene rearrangements in abalone.
Try it out:
www.ncbi.nlm.nih.gov/cgv/browse/G...
#ComparativeGenomics #NCBI
Missed one of the latest #ERGA BioGenome #Analysis and #Applications seminars? Catch up on all sessions on the ERGA YouTube Channel!
📽️ youtube.com/playlist?lis...
Topics include #Phylogenomics, #FunctionalGenomics, #PopulationGenomics, and #ComparativeGenomics.
Graduate students in the BPSC240 course are working in groups to identify orthologous genes and their evolutionary history.
BPSC240 students learning about cellular barcodes and UMIs in single-cell sequencing reads
Loving the energy in my #ComparativeGenomics & #SingleCell omics class at @ucriverside.bsky.social
Fun activities to learn functional orthologs across species & single-cell sequencing reads!
This week: a deep dive into gene expression evolution preprint
👇
biorxiv.org/content/10.1...
#comparativegenomics
#evolution
“This resource serves as a comprehensive baseline for future evolutionary studies of humans and our closest living ape relatives."
A cornucopia: new genes, surprises (for me), evolutionary rearrangements, much more and even a T2T pangenome browser.
👏 & 🙏for
1/2
We identified novel human-biased genes and epigenetic signatures and further validated them using cortical organoids and MPRA data to generate a set of highly confident putative enhancers - paving the way for future functional studies of human brain development.
#ComparativeGenomics
We have a #ComparativeGenomics #bioinformatics Postdoctoral position available jointly at the Barcelona Supercomputing Center and RMIT University lnkd.in/e_cbDBER
Submit your application by 3 April 2025 at auspire.eu
Weisman, Caroline M., Andrew W. Murray, and Sean R. Eddy. “Mixing Genome Annotation Methods in a Comparative Analysis Inflates the Apparent Number of Lineage-Specific Genes.” Current Biology 0, no. 0 (May 18, 2022). https://doi.org/10.1016/j.cub.2022.04.085.
Weisman, Caroline M., Andrew W. Murray, and Sean R. Eddy. “Mixing Genome Annotation Methods in a Comparative Analysis Inflates the Apparent Number of Lineage-Specific Genes.” Current Biology 0, no. 0 (May 18, 2022). https://doi.org/10.1016/j.cub.2022.04.085.
False positive rates in studies of gene birth/death dynamics are documented to be exceptionally high. If you just pull primary transcripts for 100 species & chuck it into CAFE pipeline, you're likely grossly overestimating lineage specific dyanmics #genomics #comparativegenomics #evolution
