Really pleased to share the *final* version of @katiegelder.bsky.social's super work, profiling the functional roles of #IDRs in CBP. Published today 🎉

🔗https://doi.org/10.1016/j.celrep.2026.117109

#IDRs #condensates #transcription #CBP #generegulation #enhancers (1/7)

🧬 Epigenetics controls how the same DNA and 46 Chromosome create different cell types in the human body.
It plays a key role in development, health, and disease.

📢 International Epigenetics Conference 2026 | Hybrid Event
🔗 epigenetics-conferences.com

#Epigenetics #GeneRegulation

Thanks for having me @danbose.bsky.social, I had such a wonderful time! Lots of cool questions & great to hear about the exciting research on #condensates and #generegulation @sheffielduni.bsky.social!

Fantastic to welcome @fariatrypslab.bsky.social for our @mcb-sheffield.bsky.social seminar today. So much cool work on #condensates and #generegulation, and can't get over how awesome #trypanosomes are!

An Epigenetic Perspective of Gene Expression: The Regulatory Tools

dl.begellhouse.com/journals/6db...

#EpigeneticsResearch #GeneRegulation #ChromatinBiology #CRE

Connect with researchers in #GeneRegulation, small RNAs, #StructuralBiology and more at the EMBO Workshop "RNA-guided genome protection" in #Caux, CH, 16–20 June 2026.

Deadine: 15 March

https://meetings.embo.org/event/26-genome-protection
#DNAsky #RNAsky #EMBORNAGenomeProtection #EMBOevents 🧪

The mirage of DNA methylation in transcriptional regulation of plants Links between DNA methylation and transcription remain difficult to generalize and are weak on genome-wide scales. Multiple lines of evidence suggest DNA methylation plays only a minor role in the r...

🧬Does DNA methylation really control gene expression in plants?
Our new paper challenges this assumption — showing that methylation and transcription often avoid one another rather than align. Why is that?
acsess.onlinelibrary.wiley.com/doi/10.1002/...
#Epigenetics #DNAmethylation #GeneRegulation

Research topics include:
#EvoDevo #DevelopmentalBiology #Genomics #Genetics #Physiology #FunctionalGenomics #SingleCell #ComparativeGenomics #Regeneration #Aging #Neurobiology #DiseaseModels #HostMicrobe #Immunology #StemCells #CellBiology #CRISPR #GeneRegulation #Epigenomics #Metabolism #Evolution

Gene expression is a finely tuned process — from chromatin remodeling to protein synthesis and degradation. Every step matters in health & disease.

📅 Epigenetics Congress 2026 | Oct 15–16
📍 Boston, USA
🌐 epigeneticscongress.com

#Epigenetics #GeneRegulation

🧬 @danielibrahim.bsky.social, moderated by @stefanschoenfelder.bsky.social, on enhancer-promoter specificity & how promoter-proximal regions act as molecular filters.

Register: us02web.zoom.us/webinar/regi...

March 5, 4PM UK.

#Genomics #GeneRegulation

Epigenetic regulation controls gene activity without changing DNA—through mechanisms like methylation and histone modification. Environment, diet, and stress all matter. 🧬

Join Epigenetics Congress 2026
📅 Oct 15–16, 2026 | 📍 Boston, USA
🔗 epigeneticscongress.com

#Epigenetics #GeneRegulation

In summary, METALoci provides novel insights on #sexdetermination, from fundamental mechanisms of #generegulation to their relevance in vivo. (19/19) These and other interesting observations (as well as many Hi-C maps!) can be found in our paper. 🌀🧬 Have a look!

Cheers, sex & rock and roll. 🍻🤘

But... 🤔💭:
Are conventional tools for Hi-C analysis well suited to identify meaningful changes for #generegulation?

How can such a minor variation in 3D chromatin organization explain a process characterised by major changes in #transcription and cell identity? (5/n)

21/n In summary, METALoci provide novel insights on #sexdetermination, going from fundamental mechanisms of #generegulation to their relevance in vivo.

This highlights the power of integrative genomic approaches to uncover the molecular underpinnings of developmental processes.

a woman says how is that possible in white letters ALT: a woman says how is that possible in white letters

6/n But are conventional tools for Hi-C analysis well suited to identify meaningful changes for #generegulation?

How can such a minor variation in 3D chromatin organization explain a process characterized by major changes in #transcription and cell identity?

A pictographic model of chromatin folding in the nucleus. DNA wrapped around nucleosomes aggregates into nanoscale domains, whilst newly nucleosome depleted DNA that forms after acute degradation of FACT projects from these domains and engages in long-range interactions that can span TAD boundaries

New preprint from @anadopico.bsky.social (who I have had the great pleasure of supervising with Tom Milne) and our fantastic collaborators in the @davieslab.bsky.social

www.biorxiv.org/content/10.6...

#genomics #GeneRegulation #chromatin

Excited to share our newest #SingleCell work on human #AlcoholUseDisorder in #Amygdala out in @natcomms.nature.com
Paper: tinyurl.com/3xh54ath
Data: zenodo.org/records/1765...
Code: github.com/mjgirgenti/A...

#Neuroscience #AlcoholUseDisorder #SingleCell #Epigenomics #GeneRegulation

Discover DNA-protein interactions with Novogene ChIP-Seq. We perform immunoprecipitation, library prep and deep sequencing to map transcription factors, histone modifications and regulatory elements. #ChIPSeq #Epigenomics #GeneRegulation https://bit.ly/4gXbq3G

Switching and Sniffing around the β-globin cluster In this issue of Blood, Bagchi et al1 show how the β-like globin genes may be regulated by “Switch-Sniff” (switch/sucrose nonfermentable) chromatin remodel

#WIMMReads
🧪 #MRCWIMM Professor Doug Higgs authors a commentary in Blood on how chromatin remodeling complexes regulate globin genes and what this could mean for reactivating fetal hemoglobin in beta thalassemia and sickle cell disease.
#Haematology #GeneRegulation #WIMM

Had a fantastic time hosting my friend @husbandslab.bsky.social (an alum of our Plant Biology Graduate program @ucriverside.bsky.social)
Cool talk on paralog-specific regulation of transcription factor families! Exciting discussion on evolutionary and regulatory divergence!
#GeneRegulation

Would you like to join the #PRBBcommunity? Discover an exceptional environment to boost your career 🚀

Check out our #joboffers 👉https://www.prbb.org/carrera.php#Ofertas-empleo

#BiomedicalInformatics #SystemsBiology
#GeneRegulation #Epigenetics #CellBiology #DevelopmentalBiology #Pharmacology

Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!

Poster abstract deadline is Feb 9th for @keystoneSymposia.bsky.social #Epigenetics & #GeneRegulation in Health, Disease & Therapeutics, this March in Geneva - @emboreports.org editor Esther Schnapp will attend!
Details and registration: hubs.la/Q03TCq-r0
#KSEpigenetics26

With 5,565 amiRNAs targeting ~82% of the transportome, mTACT enables spatially resolved genetic screens to uncover hidden regulators of signaling molecule transport.

Published in @plantphys.bsky.social

#PlantPhysiology #Arabidopsis #FunctionalGenomics #Transporters #GeneRegulation #PlantScience

Size matters for gene expression! Our review uncovers how transcription scales with cell size across kingdoms.
Read it here: sciencedirect.com/science/arti...
#GeneRegulation #CellSize #PlantScience

A useful tool for studying cytokine biology, alternative splicing, and immune regulation. 🧬🧪

Part of the book series Methods in Molecular Biology.

#GeneExpression
#GeneRegulation
#RTPCR
#Quantification
#Densitometry

SOX9 shapes liver development, homeostasis & hepatobiliary disease progression.
#SOX9 #Hepatobiliary #GeneRegulation #HepatologyResearch
www.sciencedirect.com/science/arti...

The biases and mechanisms of regulatory DNA evolution and emergence Welcome to a seminar with Dr Timothy Fuqua from the University of Bern.

If you're at the Karolinska @ki.se next Monday and are interested in #transcription or #generegulation then consider coming to my guest talk, "The biases and mechanisms of regulatory DNA evolution and emergence." Cheers!

More info here: news.ki.se/calendar/the...

KSQA: Dr Karim-Jean Armache / Dr. Cigall Kadoch (Epigenetics and Gene Regulation) YouTube video by KeystoneSymposia

Last chance to save $250! Register by Jan. 6 (11:59 pm MST) for the Keystone Symposium Epigenetics & Gene Regulation in Health and Disease. Hear from organizers @kjarmache.bsky.social & @ckadoch.bsky.social 🎥 youtu.be/sLfyuQuH8F0
🔗 hubs.la/Q03ZfFF80

#KSEpigenetics26 #Epigenetics #GeneRegulation

Uncover the roles of circular RNAs in gene regulation and disease with Novogene’s circRNA sequencing services. Gain precise insights into their expression and function.

Learn more: https://bit.ly/3P22IE7

#circRNA #CircularRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation

Explore microRNAs, siRNAs, and piRNAs with Novogene’s small RNA sequencing (sRNA-Seq) services. Gain precise insights into their regulatory roles and functions.

Learn more: https://bit.ly/3P1VkbT

#SmallRNA #sRNASequencing #MicroRNAs #GeneRegulation #Transcriptomics #GenomicsInnovation