It was discovered that moss BRCA2 lacks the typical DNA-binding domain found in most organisms. Surprisingly, it can still bind DNA using a flexible region of the protein.
#GenomeStability
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#GenomeStability
Posts tagged #GenomeStability on Bluesky
👉 Don’t miss this opportunity to explore the intricate regulatory mechanisms that safeguard genome stability and uncover new layers of translational control shaping enzyme function.
#GenomeStability #DNARepair #MolecularBiology #TranslationalControl
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🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration
By Tracy, Chen and ZZ Zhao Zhang
➡️ genesdev.cshlp.org/content/early/2026/01/22...
#retrotransposon #Drosophila #genomestability
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Excited to share our latest work on how viruses “rewire” the cell division machinery of infected cells.
Investigating viral strategies provides insights into how key cellular processes are controlled, and where they can fail.
#CellBiology #Virology #Cytokinesis #APCC #GenomeStability #Adenovirus
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Great to be back in Cambridge for this year's GSN. Some amazing talks and so great to reconnect with colleagues and to make new acquaintances.
#GSN #genomestability #chromatin #DNA
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Important insight shared by @science.org on how double-strand DNA breaks drive chromosomal rearrangements in cancer.
Explore related molecular science via SciOpen: www.sciopen.com
#MolecularBiology #CancerResearch #GenomeStability #SciOpen #TUP
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dUTPase is essential in zebrafish development and possesses several single-nucleotide variants with pronounced structural and functional consequences
buff.ly/TEKZy16
#zebrafish #GenomeStability
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We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance.
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
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We’re grateful to our Bronze sponsor @proteintech.bsky.social for supporting this week’s seminar.
#DNAReplication #GenomeStability #MolecularBiology #LifeSciences
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We’re delighted to welcome Prof. Grant Stewart (Uni. of Birmingham) for our next BLS Seminar Series talk:
“The integrity of the DNA replication process is intimately linked with maintaining genome stability.” 🧬
#DNAReplication #GenomeStability #MolecularBiology #LifeSciences
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🚨 New paper alert!!
RNA-binding proteins ZFP36L1 & ZFP36L2 act as guardians of genome stability in fast-dividing germinal center B cells.
A new mechanism showing how post-transcriptional control keeps our immune cells in check!
#RNA #Bcells #GenomeStability
www.science.org/doi/10.1126/...
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What if ICL repair isn’t one pathway’s job?
DNA Repair (2025): NHEJ, TMEJ & HR co-contribute to crosslink repair, with dependencies shifting when NHEJ is impaired. Survival readouts (Fig. 1, 3, 4) were supported by #GelCount to image and analyze the clonogenic assays.
#DNARepair #GenomeStability
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A transcription balance required for genome stability 🧬⚖️
Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on @natsmb.nature.com
#CryoEM #transcription #genomestability
www.nature.com/articles/s41...
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#DNAReplication
#GenomeStability
#MolecularBiology
#Biophysics
#SingleMolecule
#FluorescenceMicroscopy
#ForceSpectroscopy
#Replisome
#CancerResearch
#CellBiology
#MolecularMachines
#LiveScience
#ReplicationStress
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What if we could stop DNA repair errors before they happen — by moving the damage out of danger? #DNAdamage #CancerResearch #GenomeStability
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G-quadruplexes (G4s) stall replisomes: a single G4 in leading strand stops CMG helicase. Cryo-EM details yeast & human structures. #GenomeStability PMID:40048517, Science 2025, @ScienceMagazine https://doi.org/10.1126/science.adt1978 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
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📢New opportunity for Lab technician!📢
If you're interested in #telomeres and #genomestability, and would like to join our team @gimmfoundation.bsky.social, don't miss this chance!
Application details at gimm.pt/jobs/technic...
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And don't forget to follow us if you share our interest in #telomeres, #lncRNAs, #cancer, #aging, and #genomestability!
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Schematic of the findings. This study reveals two distinct pools of Atg11 in S. cerevisiae. A lower proportion of Atg11 which is less dynamic canonically localizes at the pre-autophagosomal structures (PAS) onto the vacuolar membrane, necessary for selective autophagy and dependent on actin. While the more dynamic Atg11 localizes at the SPBs in a higher proportion which is critical for high-fidelity chromosome segregation. The asymmetric Kar9 localization together with the dynamic instability of MTs is crucial for pre-anaphase spindle positioning and alignment, and chromosome biorientation. Before anaphase onset, aMTs are unstable and cyclin Clb4 levels are high. The mono-oriented kinetochores have defective tension, leading to the activation of Ipl1. Ipl1 carries out the disassembly of defective kinetochore-MT attachments via phosphorylation and activates SAC. SAC delays anaphase onset until biorientation is achieved. Upon biorientation, SAC is silenced, Pds1 gets degraded, separase is activated, and Cdc14 is released from the nucleolus via the FEAR pathway leading to proper sister chromatid separation. APC-C/Cdc20 also degrades Clb4 upon anaphase onset crucial for the stability of aMTs. Atg11 ensures asymmetric localization of both Spc72 and Kar9 at the dSPB, critical for non-random SPB inheritance.
Are #autophagy -related proteins involved in #GenomeStability? @hashimreza.bsky.social @kaustuvsanyal.bsky.social &co show that Atg11 has an essential non-canonical function in error-free #chromosome segregation via the Kar9-dependent spindle positioning pathway @plosbiology.org 🧪 plos.io/4lfbeP1
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Schematic of the findings. This study reveals two distinct pools of Atg11 in S. cerevisiae. A lower proportion of Atg11 which is less dynamic canonically localizes at the pre-autophagosomal structures (PAS) onto the vacuolar membrane, necessary for selective autophagy and dependent on actin. While the more dynamic Atg11 localizes at the SPBs in a higher proportion which is critical for high-fidelity chromosome segregation. The asymmetric Kar9 localization together with the dynamic instability of MTs is crucial for pre-anaphase spindle positioning and alignment, and chromosome biorientation. Before anaphase onset, aMTs are unstable and cyclin Clb4 levels are high. The mono-oriented kinetochores have defective tension, leading to the activation of Ipl1. Ipl1 carries out the disassembly of defective kinetochore-MT attachments via phosphorylation and activates SAC. SAC delays anaphase onset until biorientation is achieved. Upon biorientation, SAC is silenced, Pds1 gets degraded, separase is activated, and Cdc14 is released from the nucleolus via the FEAR pathway leading to proper sister chromatid separation. APC-C/Cdc20 also degrades Clb4 upon anaphase onset crucial for the stability of aMTs. Atg11 ensures asymmetric localization of both Spc72 and Kar9 at the dSPB, critical for non-random SPB inheritance.
Are #autophagy -related proteins involved in #GenomeStability? @hashimreza.bsky.social @kaustuvsanyal.bsky.social &co show that Atg11 has an essential non-canonical function in error-free #chromosome segregation via the Kar9-dependent spindle positioning pathway @plosbiology.org 🧪 plos.io/4lfbeP1
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Schematic of the findings. This study reveals two distinct pools of Atg11 in S. cerevisiae. A lower proportion of Atg11 which is less dynamic canonically localizes at the pre-autophagosomal structures (PAS) onto the vacuolar membrane, necessary for selective autophagy and dependent on actin. While the more dynamic Atg11 localizes at the SPBs in a higher proportion which is critical for high-fidelity chromosome segregation. The asymmetric Kar9 localization together with the dynamic instability of MTs is crucial for pre-anaphase spindle positioning and alignment, and chromosome biorientation. Before anaphase onset, aMTs are unstable and cyclin Clb4 levels are high. The mono-oriented kinetochores have defective tension, leading to the activation of Ipl1. Ipl1 carries out the disassembly of defective kinetochore-MT attachments via phosphorylation and activates SAC. SAC delays anaphase onset until biorientation is achieved. Upon biorientation, SAC is silenced, Pds1 gets degraded, separase is activated, and Cdc14 is released from the nucleolus via the FEAR pathway leading to proper sister chromatid separation. APC-C/Cdc20 also degrades Clb4 upon anaphase onset crucial for the stability of aMTs. Atg11 ensures asymmetric localization of both Spc72 and Kar9 at the dSPB, critical for non-random SPB inheritance.
Are #autophagy -related proteins involved in #GenomeStability? @hashimreza.bsky.social @kaustuvsanyal.bsky.social &co show that Atg11 has an essential non-canonical function in error-free #chromosome segregation via the Kar9-dependent spindle positioning pathway @plosbiology.org 🧪 plos.io/4lfbeP1
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Stucki and colleague @show how MDC1 recruits E3 ligases to repair DNA breaks 🧬🔬 #GenomeStability #DNADamageRepair
bioRxiv doi.org/10.1101/2024.07.20.60439
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Let’s spread the science! #DNARepair #GenomeStability #NuclearOrganization #Cancer #Aging #MolecularBiology #ScienceCollaboration
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Safe the Date - the next German French DNA repair meeting will be Nov 5-7th in Paris
Love to see many friends of the genome stability community
There:
premc.org/dnarepair2025/
#genomestability, #repair, #chembio
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Save the date! On March 25th, We'll dive into Nanofluidic tools for studying DNA repair with Fredrik Westerlund and R-loops & genome instability with Sidrit Uruci & Agnese Cristini. Don't miss out! 🗓️ #DNARepair #GenomeStability
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Available online - the Review "Z-DNA at the crossroads: untangling its role in genome dynamics" from Hiroshi Sugiyama and colleagues.
#ZDNA #noncanonicalDNA #mtDNA #transcription #genomestability
Access it here 👉 authors.elsevier.com/a/1kW6s3S6Gf...
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You are interested in genome stability and on nucleic acid structures? And you would like to work in an international young team? We are looking for you- there are two open PhD in my lab open. Please contact me #biochem
#genomestability
#g4
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Selfie in the new research lab.
Super excited for my first day as Assistant Prof at @cuanschutz.bsky.social in the Dept of Pharmacology! The lab is open, and now I can't wait to do exciting science! #FirstGen #newPI #STEM #AcademicLife #ExcitingScience #PhDLife #WomenInSTEM #MomInSTEM #GenomeStability #CellBiology #DNARepair
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Excited to present an update on my work investigating chromatin 🧬 and replication stress ⚡️ at the Australasian Epigenetics Alliance Conference next month in New Zealand🇳🇿!
Conference programme is now live! www.aepia.org.au/conferences
#epigenetics #chromatin #replication #genomestability #AEpiA
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