The key to attacking “undruggable” proteins: #IRBBarcelona reveals a breakthrough drug mechanism.
📰 Science Advances
➡️ https://bit.ly/4u2xBvh
📌 DOI: 10.1126/sciadv.adz74
@xsalvatella1.bsky.social @mpi-cbg.de
#IRBScience #NuageTx
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🔬 The key to attacking “undruggable” proteins: #IRBBarcelona reveals a breakthrough drug mechanism.
📰 Published in Science Advances
➡️ bit.ly/4u2xBvh
📌 DOI: 10.1126/sciadv.adz74
@xsalvatella1.bsky.social @mpi-cbg.de
#IRBScience #NuageTx
🗣️ @ptck72.bsky.social: “Recognising protein degradation as part of kinase inhibitor mechanisms expands the possibilities for designing more effective therapies”.
#IRBScience #ProteinDegradation #TPD #DrugDiscovery
@cerca.cat @icreacommunity.bsky.social @bist.eu
Related article: "A dual TGF-β immunosuppressive barrier impedes T cell recruitment and expansion in metastatic colorectal cancer".
📰 @natgenet.nature.com
📌 doi.org/10.1038/s415...
#IRBScience #CancerResearch #ColorectalCancer #Immunotherapy
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🔬 #ColorectalCancer evades #immunotherapy using a dual barrier:
A study by #IRBBarcelona & @cnag-eu.bsky.social reveals how metastatic colorectal tumours block the immune system through two complementary mechanisms.
📰 @natgenet.nature.com
➡️ bit.ly/49BJaC0
#IRBScience @batllelab.bsky.social
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🔍 A fantastic session of #Descubre, led by Dr. Modesto Orozco, from the Molecular Modeling & Bioinformatics group.
🗣️Sharing #IRBscience with #IRBBarcelona's administrative & technical staff.
Thank you, Dr. Orozco 🙌
🔬An aggressive #ChildhoodCancer case opens new avenues for advanced cell therapies.
✍️ #IRBBarcelona, @cnag-eu.bsky.social, @sjdhospitalbarcelona.org
📰 Annals of Oncology
Read more here ➡️ bit.ly/40Ut5lC
📌 DOI: 10.1016/j.annonc.2025.05.530
#IRBScience
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The study suggests that while current methods are useful for proposing potential molecular interactions, they are insufficient to reflect how the local microenvironment dictates actual cell-to-cell dialogue.
➡️ bit.ly/4lDSLeZ
📌 DOI: 10.1186/s13059-025-03677-5
#IRBScience
🔬 A new study by #IRBBarcelona reveals the limitations of current methods used to study cell communication.
📰 #GenomeBiology
✍️ @epareja10.bsky.social @ptck72.bsky.social
➡️ bit.ly/4kvcD2a
📌 DOI: 10.1186/s13059-025-03677-5
#IRBScience
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Más de 100 expertos, coordinados desde el #IRBBarcelona, reclaman que los datos en simulación molecular se ajusten a los principios 'Fair': accesibles, interoperables, fáciles de encontrar y reutilizables.
📰 @lavanguardia.com
🔗 https://f.mtr.cool/ncjierxuzt
#IRBScience #MolecularSimulation
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Over 100 experts in #MolecularSimulation, coordinated by #IRBBarcelona, have published an article in @naturemethods.bsky.social advocating for a paradigm shift in #MolecularDynamics data management.
Read more here ➡️ https://f.mtr.cool/prgasqrqyx
📌 DOI: 10.1038/s41592-025-02635-0
#IRBScience 🧪
🔬Exposomal determinants of non-genetic plasticity in tumor initiation.
✍️ Davide Carra, Silvana C.E. Maas, @seoaneja.bsky.social, @direnaac.bsky.social
📰 @cp-trendscancer.bsky.social
Read more here 🔗 https://shorturl.at/CaicQ
📌 DOI: https://doi.org/10.1016/j.trecan.2025.01.010
#IRBScience 🧪
#PCBCommunity |🧬 Un equip de @irbbarcelona.org revela el rol dels tríplex híbrids d’ADN i ARN en la regulació gènica. 🔬 L'estudi descriu per primera vegada quins tríplex híbrids (ADN-ARN) són més estables a la cèl·lula i com es distribueixen al #genoma humà. 🧪 #IRBScience
➕ Més info 👉 qrcd.org/8WlQ
🧬 A Study Reveals the Role of Hybrid DNA-RNA Triplexes in Gene Regulation.
✍️ @jalbiti.bsky.social, Vito Genna, Guillem Portella, Modesto Orozco et al.
📰 @narjournal.bsky.social
➡️ https://f.mtr.cool/iuuqosjozf
📌 DOI: 10.1093/nar/gkaf170
#IRBScience
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🧪 Researchers at IRB Barcelona develop the first single-cell map of transcriptomes in yeast.
✍️ Mariona Nadal-Ribelles, @laia-de-nadal.bsky.social, Francesc Posas et al.
📰 @naturecomms.bsky.social
➡️ https://shorturl.at/R8i9e
📌DOI: 10.1038/s41467-025-57600-4
#IRBScience
The team also identified several genetic factors that regulate the variability of stress genes.
This study involved researchers from @unil.bsky.social and the @institutcurie.bsky.social.
Read more here ➡️ bit.ly/4ij4DBi
🧪 DOI: 10.1038/s41467-025-57911-6
#IRBScience
🧪 Researchers at #IRBBarcelona reveal that genetically identical cells can respond in distinct ways to the same stress.
✍️ Mariona Nadal, Francesc Posas, @laia-de-nadal.bsky.social et al.
📰 @naturecomms.bsky.social
➡️ bit.ly/4hwfhDG
📌 doi.org/10.1038/s414...
#IRBScience
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🧪 Defect in amino acid transport reduces the production of erythropoietin and compromises the formation of red blood cells.
✍️ Dr. @sbodoy.bsky.social, Dr. Manuel Palacín et al.
📰 Molecular Medicine
➡️ rb.gy/1jych8
📌DOI: 10.1186/s10020-025-01100-0
#IRBScience #Anemia #LPI #RareDiseases
🧪 Researchers at #IRBBarcelona discover a molecular ‘interrupter’ that regulates amino acid entry into cells.
🔬Led by Dr. Manuel Palacín and Dr. @joanafb.bsky.social, the work has been published in the journal @pnasnexus.org.
➡️ https://bit.ly/4haHwaB
📌DOI: 10.1093/pnasnexus/pgae584
#IRBScience
🧪Researchers at @irbbarcelona.org and the @upf.edu unravel peroxiredoxinylation, a type of post-translational modification.
✍️ Gerhard Seisenbacher, @laia-de-nadal.bsky.social, Francesc Posas, et al.
📰 Cell Reports
➡️ bit.ly/4k53Hlq
📌DOI: 10.1016/j.celrep.2024.115224
#IRBScience #ChemBio
#PCBCommunity |🧫Científics del @irbbarcelona.org revelen la influència de les mitocòndries en l'autofàgia utilitzant l'edició genètica #CRISPR-Cas9. L'estudi obre la porta a noves teràpies per #malaltiesmetabòliques i promoure l'envelliment saludable.💓🩺 #IRBScience #autophagy
👉 tinyurl.com/254rkkrl
🧪 Researchers at @irbbarcelona.org discover how #mitochondria drive #autophagy.
📰 Autophagy
✍️ Saška Ivanova, Isabel Gordaliza-Alaguero, Antonio Zorzano et al.
➡️ bit.ly/42Tc11q
📌 doi.org/10.1080/1554...
#IRBScience #Mitochondria #Scicomm
🧪#NewPaper: "Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis."
📰 Molecular Medicine
✍️ @sbodoy.bsky.social, Manuel Palacín, @AntonioZorzano et al.
➡️ https://tinyurl.com/prtsyz93
📌 https://doi.org/10.1186/s10020-025-01100-0
#IRBScience
🤝 #MeetOurScientists: Dr. @crismayorruiz.bsky.social.
🎯🔬 Learn how Dr. Mayor-Ruiz's pioneering work in #TargetedProteinDegradation is unlocking new ways to treat untouchable diseases.
📽️ https://s.mtrbio.com/higqmhbfzt
#IRBScience #ProteinDegradation #TPD
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This discovery marks a step forward in the fight against resistance to cancer treatment. By targeting #PersisterCells, the likelihood of relapse could be reduced, thus improving patient prognosis.
➡️ bit.ly/40xlXfl
📌DOI: 10.1158/0008-5472.CAN-24-0529
#IRBScience
(2/2) They investigated mitofusin 1 and mitofusin 2 proteins ( #UniProt #Q8IWA4 and #O95140) and their role in interorganelle communication and autophagy. Congratulations to the first author, Isabel Gordaliza, and the whole team behind this outstanding job. #IRBScience
(1/2) Our friends from the Complex Metabolic Diseases and #Mitochondria @irbbarcelona.org group lead by Antonio Zorzano have recently published a #Paper in #Autophagy Journal ( s.mtrbio.com/lnbugdbrhi ). #IRBScience
🔬 Dr. Stefanie Wculek is a leading expert in innate immune biology.
🦠 Explore her research and the cutting-edge science behind innate immune cells and their role in health and disease.
▶️ youtu.be/JEz0Ake9-Ro
#MeetOurScientists #IRBScience
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📜🔬"Endogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy"
📰 Published in #Autophagy
✍️ Isabel Gordaliza-Alaguero, Antonio Zorzano et al.
➡️ shorturl.at/mThnD
📌 https://s.mtrbio.com/lnbugdbrhi
#IRBScience 🧪
🔬 Major advance in #AutismResearch: Dr. Carla Garcia-Cabau (IRB Barcelona) explains the key role of #CPEB4 condensates in #autism.
📰 Published in Nature
📌 DOI: doi.org/10.1038/s41586-024-08289-w
#IRBScience @xsalvatella1.bsky.social @natureportfolio.bsky.social
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