The exocyst complex component EXOC6B is a key mediator of fungal-induced IL-33 secretion from pancreatic cancer cells, unraveling a novel mechanism by which the #TumorMycobiome modulates the #ImmuneMicroenvironment. @roswellpark.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
Host-derived FSTL1 potentiates Ly6C+ monocytes /macrophages recruitment via the CD14/TLR4/NF-κB axis to modulate the hepatic #Fibrotic #ImmuneMicroenvironment, serving as a key #Biomarker for #MesenchymalStemCell therapy outcomes.
#STTT #OpenAccess: doi.org/10.1038/s413...
This #STTT study identified selective SAMHD1 depletion as a dual-action strategy to sensitize tumors to #Chemotherapy and prime the #ImmuneMicroenvironment, offering a novel approach to overcome therapeutic resistance.
#OpenAccess: doi.org/10.1038/s413...
This review highlights the critical role of the #ImmuneMicroenvironment in #ADPKD progression, detailing how immune cells, #inflammation, complement activation, and immune checkpoints like PD-1/PD-L1 contribute to #CystGrowth and #fibrosis.
#OpenAccess: doi.org/10.1016/j.ge...
FSTL1 promotes CCR2 recycling and early Ly6C⁺ monocyte/macrophage recruitment in the fibrotic #ImmuneMicroenvironment, thus showing potential as a biomarker of #StemCellTherapy response in #LiverCirrhosis. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#SingleCellSequencing in CML patients reveals expansion and diversity of #Tcell subsets and how the interaction between bone marrow microenvironment cells and T cell subsets influences #ImmuneMicroenvironment changes. #medsky
#MostRead
#OpenAccess:
buff.ly/b5ai8J0
Exciting read! Most downloaded article!
This review provides a comprehensive understanding of the #ImmuneMicroenvironment in #endometrialcarcinoma (EC) and elucidates the composition and functions of tumor-infiltrating immune cells. #ImmuneCheckpoint #medsky
#OpenAccess: buff.ly/KxlgQHt
This review explores the intricate interplay between different components of the #ImmuneMicroenvironment and the associated mechanisms in the #pathogenesis of #ADPKD, and summarizes the currently available & potential #Immunotherapeutic approaches. #RenalDysfunction #medsky
buff.ly/yR6zEod
👀 for a #postdoc to join us. #Ttanslational #Radiobiology #Immunemicroenvironment If you're interested, get in touch @mcrcnews.bsky.social @uniofmanchester.bsky.social
www.jobs.manchester.ac.uk/Job/JobDetai...
Molecular mechanism of tumor-infiltrating immune cells regulating endometrial carcinoma
This review provides a comprehensive understanding of the #ImmuneMicroenvironment in #endometrialcarcinoma (EC) and elucidates the composition and functions of tumor-infiltrating immune cells.
#OpenAccess: https://buff.ly/4alwIVf
Molecular mechanism of tumor-infiltrating immune cells regulating endometrial carcinoma
This review provides a comprehensive understanding of the #ImmuneMicroenvironment in #endometrialcarcinoma (EC) and elucidates the composition and functions of tumor-infiltrating immune cells.
#OpenAccess: www.sciencedirect.com/science/arti...
This paper describes iAtlas, our open source #Shiny app for data exploration and discovery in the context of tumors and their interactions with the #immunemicroenvironment. This is a collaboration between #ISB,
#UNCChapelHill, and #SageBionetworks, funded by @CancerResearch 2/3
