So far in March, we've featured papers on:
• how inflammatory #ILC2 migrate
• engineering #CAR-TCells to restore #checkpoint sensitivity
• capturing the earliest events of #TCell #development
• how certain dietary antigens recognized by #Tregs help mediate #OralTolerance
New content every week!
📢 New in @nature.com!
Work led by Dr. R. Brad Jones at Weill Cornell Medical College shows that persistent #HIV reservoir T cell clones resist immune clearance but remain vulnerable to sustained cytotoxic #TCell pressure.
🗒️ https://go.nature.com/4svfY62
🔊 https://bit.ly/3OVwMo6
we find that #TVEC combined with #MEK #inhibitor #binimetinib induced exceptional clinical responses by amplification of pre-existing #Tcell responses and induction of de novo tumor-reactive immunity.
This study shows that single-cell profiling of #HCC under anti-PD-1 therapy reveals #Tcell exhaustion trajectories linked to tumor–immune crosstalk, highlighting exhaustion as a key target to improve #immunotherapy outcomes. #SingleCellRNASequencing
#OpenAccess: doi.org/10.1016/j.ge...
Yönetim kurulu, bağlı ortaklık aracılığıyla 3 Milyar TL’ye kadar, 12 aya vadeli, tahsisli veya nitelikli yatırımcıya kira sertifikası ihracı kararı aldı.
#TCELL
TCELL firmasının 2025/12 dönem bilançosu açıklandı.
Tcell'in bilanço puanı, likidite ve kârlılık oranlarındaki düşüş nedeniyle 9.03'ten 8.85'e geriledi, ancak verimlilikteki artış bu düşüşü tam olarak dengeleyemedi.
#TCELL @borsacoo
borsacoo.com
Yuran Miao, Liwan Lin, Zhixi Chen and colleagues show that "Leukocyte immunoglobulin-like receptor subfamily B member 1 (#LILRB1) expression defines CD8+ #Tcell #Exhaustion in acute myeloid #Leukemia"
Successful strains accumulate mutations that confer high escape without sacrificing the high infectivity achieved in earlier stages.
#TCell Evasion:Beyond antibodies, there is emerging evidence of the virus evolving to escape cellular (T cell) immunity, particularly in cases of prolonged infection
JCI - α4 integrin blockade impairs CD8 T cell neuroimmune surveillance following SIV infection www.jci.org/articles/vie...
#Neuroimmunology #HIV #SIV #Neuroscience #Immunology #JCI #TCell #Integrin #CNS #Research
STAT5-activating oncogenes drive #OncostatinM production to remodel the bone marrow niche and induce #TCell exhaustion, identifying the OSM axis as a key target for treating aggressive hematologic malignancies. #Medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
This Science Immunology article talks about the #aging immune system!
The Winer lab at @utoronto.ca showed how #Bcells affect #Tcell aging.
📃 https://bit.ly/4aDfEuK
🎤 https://bit.ly/4kEDz1s
www.teknolojihabermerkezi.com
www.teknolojihabermerkezi.com
📌 İYİ Parti lideri #MüsavatDervişoğlu 'ndan MHP lideri Bahçeli'ye: "Sen benim dava arkadaşım değilsin, Abdullah Öcalan'ın dava arkadaşısın. Senin dava arkadaşların İmralı'da."
#BekirBozdağ #kchol #tcell #FekuGheeFekuJagan #THM
www.teknolojihabermerkezi.com
www.teknolojihabermerkezi.com
Yunanistan Başbakanı Miçotakis:
Venizelos ve Atatürk'ün mirasına sahip çıkmak zorundayız.
#BekirBozdağ #kchol #tcell #FekuGheeFekuJagan #THM
www.teknolojihabermerkezi.com
İrlanda, sanatçılara destek olmak için haftalık 325 euro (16.815 TL) ödeme yapacak.
• Mayıs ayında açılacak başvurularda 2 bin sanatçı seçilecek.
• Seçilen sanatçılar 3 yıl boyunca haftalık ödeme alacaklar.
#BekirBozdağ #kchol #tcell #FekuGheeFekuJagan #THM
Model describing the effect of CUL5 on the sensitivity of bladder cancer cells to CD8+ T cell-mediated killing. CUL5-KO could reduce the ubiquitination of PTBP1, thereby increasing the alternative splicing of RUBCN pre-mRNA, leading to an increase in Rubicon-S which inhibits autophagy, and thus enhances the sensitivity of bladder cancer cells to CD8+ T cell-mediated killing (cartoon created in BioRender).
CD8+ T cells can target & eliminate malignant #tumor cells, but tumors can develop resistance mechanisms to escape them. This study shows that loss of the E3 #ubiquitin ligase CUL5 enhances CD8+ #Tcell #cytotoxicity & anti PD-1 efficacy by inhibiting #autophagy @plosbiology.org 🧪 plos.io/3Mv1EuR
Model describing the effect of CUL5 on the sensitivity of bladder cancer cells to CD8+ T cell-mediated killing. CUL5-KO could reduce the ubiquitination of PTBP1, thereby increasing the alternative splicing of RUBCN pre-mRNA, leading to an increase in Rubicon-S which inhibits autophagy, and thus enhances the sensitivity of bladder cancer cells to CD8+ T cell-mediated killing (cartoon created in BioRender).
CD8+ T cells can target & eliminate malignant #tumor cells, but tumors can develop resistance mechanisms to escape them. This study shows that loss of the E3 #ubiquitin ligase CUL5 enhances CD8+ #Tcell #cytotoxicity & anti PD-1 efficacy by inhibiting #autophagy @plosbiology.org 🧪 plos.io/3Mv1EuR
Model describing the effect of CUL5 on the sensitivity of bladder cancer cells to CD8+ T cell-mediated killing. CUL5-KO could reduce the ubiquitination of PTBP1, thereby increasing the alternative splicing of RUBCN pre-mRNA, leading to an increase in Rubicon-S which inhibits autophagy, and thus enhances the sensitivity of bladder cancer cells to CD8+ T cell-mediated killing (cartoon created in BioRender).
CD8+ T cells can target & eliminate malignant #tumor cells, but tumors can develop resistance mechanisms to escape them. This study shows that loss of the E3 #ubiquitin ligase CUL5 enhances CD8+ #Tcell #cytotoxicity & anti PD-1 efficacy by inhibiting #autophagy @plosbiology.org 🧪 plos.io/3Mv1EuR
Therapies that counter aldehyde toxicity, improve mitochondrial health, and restore FAO are therefore promising approaches to reinvigorating #Tcell anticancer responses & overcoming resistance to PD-1–based therapeutics.
@nature.com
www.science.org/doi/10.1126/...
www.nature.com/articles/s41...
#Medsky🧪 #oncosky #Immunosky #publichealth these studies demonstrate that #Tcell mitochondrial health is tightly linked to immune fitness and that active aldehydes derived from metabolic dysfunction in the tumor microenvironment damage mitochondria and drive #Tcellexhaustion.
Turkcell, 2025 yılı finansal sonuçlarını 5 Mart 2026’da borsa kapanışı sonrası açıklamayı planlıyor.
#TCELL
clinicaltrials.gov/study/NCT059...
www.msaustralia.org.au/news/ms-risk...
mstrials.org.au/fatigue-in-r...
- Adoptive T-Cell Therapies
ATA188 (Atara Biotherapeutics): An allogeneic ("off-the-shelf") #Tcell therapy
Yönetim kurulu, bağlı ortaklığı Turkcell Ödeme'nin 3 Milyar TL’ye kadar, 12 aya vadeli, tahsisli sukuk ihracı için karar aldı. İhraç SPK onayına tabi.
#TCELL
I will be presenting my work as a poster at the #FOG2026
You can find the abstract here:
festivalofgenomics.com/london/poste...
I would be very happy to chat about the work, exchange ideas, or simply connect. Please feel free to stop by or reach out. #MASLD #MASH #TCELL
This study connects the environmental and genetic risk factors for #multiplesclerosis into a single, biologically coherent mechanism. #EBV-infected B cells and HLA-DR15–restricted #Tcell responses converge on myelin.
www.linkedin.com/posts/drmelv...
☕Borsa et al. show that asymmetric #Tcell division after activation requires #autophagy to promote #mitochondria turnover, with T cells inheriting older mitochondria showing decreased degradation, reduced memory potential and altered metabolism.
bit.ly/458ODgL
