New work @jem.org from Duan, Fairbrother et al. @brown.edu reveals how intronic Alu repeats and #RNA metabolism shape endogenous #dsRNA levels and cell-intrinsic immunity. rupress.org/jem/article/...

#InnateImmunity #Inflammation

New work from Duan, Fairbrother et al. @brown.edu reveals how intronic Alu repeats and #RNA metabolism shape endogenous #dsRNA levels and cell-intrinsic immunity. rupress.org/jem/article/...

#InnateImmunity #Inflammation

⏰ Reminder: There’s still time to register & submit an abstract for the 21st International Conference on Innate Immunity!
🎓 Travel awards available
📅 May 22–27, 2026 | 📍 Kalimera Kriti Hotel & Conference Center 🇬🇷
#InnateImmunity #Immunology aegeanconferences.org/src/App/conf...

Schematic overview of the findings of the publication by Suarez-Csrmona et al.

New publication on the role of #macrophages in shaping the tumor #microenvironment in #cancer ... leading to the exploration of #adipose tissue and it's impact on #innateimmunity and #adaptiveimmunity in #ovariancancer to the point where resistancr to […]

[Original post on mstdn.science]

🧫 Join us in Crete 🇬🇷 for the 21st Intl Conf. on Innate Immunity (May 22–27, 2026)!
🎓 Students & trainees—travel awards available!
📍 Kalimera Kriti Conf. Center
🔗 www.aegeanconferences.org/src/App/orga...
#InnateImmunity #Immunology #ScienceTravel

In @jem.org, David, @mlfremond.bsky.social et al. investigate whether the common HAQ STING allele explains clinical non-penetrance in COPA syndrome. rupress.org/jem/article/...

#HumanDiseaseGenetics #InnateImmunity #inflammation

David, @mlfremond.bsky.social et al. investigate whether the common HAQ STING allele explains clinical non-penetrance in COPA syndrome. rupress.org/jem/article/...

#HumanDiseaseGenetics #InnateImmunity #inflammation

New study from the labs of Willinger, Lambrecht, Marichal and colleagues found that #cholesterol metabolites recognized by the receptor GPR183 attract #monocytes to repopulate depleted lung #macrophage niches. rupress.org/jem/article/...

#Metabolism #MucosalImmunology #InnateImmunity #inflammation

New study @jem.org from the labs of Willinger, Lambrecht, Marichal and colleagues found that #cholesterol metabolites recognized by the receptor GPR183 attract #monocytes to repopulate depleted lung #macrophage niches. rupress.org/jem/article/...

#Metabolism #MucosalImmunology #InnateImmunity

Immune checkpoint inhibitor induced myocarditis is dependent on CD8 T cell-derived TNF and TNFR2 signaling. New study from Kathrynne A. Warrick, Chandrashekhar Pasare and colleagues @cincychildrens.bsky.social: rupress.org/jem/article-...

#CardiovascularBiology #InnateImmunity #TumorImmunology

Sticky memories of an activated #macrophage. Luca Frosio and Renato Ostuni @ostunilab.bsky.social @unisr.bsky.social discuss new findings by Gorin et al. (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...

#InnateImmunity #inflammation

IFNγ-induced memory in human #macrophages is sustained by the durability of #cytokine signaling itself. New study from Aleksandr Gorin, Alexander Hoffmann and colleagues @ucla.edu: rupress.org/jem/article/...

#InnateImmunity #inflammation

In @jem.org, Warrick, Pasare et al. @cincychildrens.bsky.social show that PD-1 blockade leads to de novo priming of self-reactive CD8 T cells resulting in immune related adverse events. rupress.org/jem/article-...

#CardiovascularBiology #InnateImmunity #inflammation #TumorImmunology

Warrick, Pasare et al. @cincychildrens.bsky.social show that PD-1 blockade leads to de novo priming of self-reactive CD8 T cells resulting in immune related adverse events. rupress.org/jem/article-...

#CardiovascularBiology #InnateImmunity #inflammation #TumorImmunology

Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

Poster deadline is approaching for @keystoneSymposia.bsky.social #InnateImmunity: Diversity in #HostDefense & Disease, this March in Banff! See scholarship, abstract and registration: keysym.us/KSInnateImmune26 #KSInnateImmune26 @jkagan1.bsky.social @brozlab.bsky.social

Acute pancreatitis is driven by complex inflammatory and immune mechanisms, with emerging therapeutic approaches targeting disease initiation and progression.
doi.org/10.1038/s413...
#AcutePancreatitis #Inflammation #InnateImmunity #TherapeuticTargets

We deleted a rhomboid protease… and regeneration went into overdrive.

New preprint from the Neal Lab!
Rhbdl2 restrains macrophage-driven regeneration in zebrafish. 🐟🔥 #Regeneration #InnateImmunity
www.biorxiv.org/content/10.6...

Still a chance to register for @keystonesymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March in Banff!
Our @embojournal.org subject editor Ioannis Papaioannou is looking forward to joining you there!
#KSInnateImmune26
hubs.la/Q03TCrHw0

🪰🔬 Thrilled to share our latest article on Drosophila innate immunity and gut-immune interactions! Grateful for the team's hard work and excited for your thoughts! #DrosophilaResearch #InnateImmunity #GutImmuneAxis

onlinelibrary.wiley.com/share/author...

SIRT4 regulates antiviral and autoimmune responses by promoting cGAS-mediated signaling pathways - EMBO Reports Cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS) is a critical cytosolic DNA sensor, whose activity can be regulated by acetylation. Here, we show that nicotinamide adenine dinucleotide (NAD+)...

'SIRT4 interacts with cGAS and deacetylates cGAS directly, thereby promoting the binding of cGAS with cytosolic DNA and the generation of cGAMP. SIRT4 deficiency impairs DNA virus- or cytosolic DNA-triggered signaling.'
#Immunology #InnateImmunity

Join us for the upcoming innate immunity keystone. There’s a great lineup of speakers.
@keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March!
keysym.us/KSInnateImmune26 #KSInnateImmune26

Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

Deadlines are approaching for @keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March in Banff! See key dates: keysym.us/KSInnateImmune26 #KSInnateImmune26

Abstract Submission, Travel Award Applications, and Early Fee Deadline Extended to February 28. Join us at the 21st International Conference on #Innate #Immunity
in #Sissi #Crete #Greece May 22-27, 2026 #InnateImmunity www.aegeanconferences.org/src/App/conf...

Dose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cells Interferons (IFNs) initiate antiviral defence when infected cells sense a virus protecting against infection via JAK/STAT signaling, but can hinder recovery by impairing tissue repair by an unknown me...

#Epithelialmechanics fans...interferons protect against viruses but also impair recovery post-infection. In new work @plosbiology.org we show that interferons block epithelial repair by co-opting the Hippo pathway #innateimmunity #lungs #respiratory journals.plos.org/plosbiology/...

Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

Submit your poster abstract until Feb 19 for @keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March in Banff! See abstract and reg dates: hubs.la/Q03TCrHw0 #KSInnateImmune26 @embojournal.org

In the final stretch of my DPhil at @ox.ac.uk, working on how the soluble interferon receptor IFNAR2a modulates type I interferon signalling in infection and autoimmunity.

Excited to see where this work leads next!

#Immunology #InnateImmunity #Interferon

IFI16 senses and protects stalled replication forks Gamble et al. demonstrate that detection of stalled replication forks by the innate immune sensor IFI16 induces an early STING-dependent pro-inflammatory cytokine response independently of cGAS and DN...

'We demonstrate that replication stress initiates the rapid induction of an NF-κB-mediated innate immune response prior to elevated DNA damage or micronuclei formation. This response is driven by IFI16 and STING but is independent of cGAS.'
#Immunology #InnateImmunity

Rehwinkel Group: Nucleic Acid Sensing

🔗 Rehwinkel Group lab page:
www.rdm.ox.ac.uk/about/our-di...

#WIMMSpotlight #WIMMCommunity #Immunology #InnateImmunity #AntiviralResearch #Interferon #PhDStudent #MRCWIMM

The 6th International Conference on Innate Lymphoid Cells (#ILC6) will take place
📍 Vancouver, Canada | 🗓 June 2–4, 2026

📝 Registration & abstract submission are now open.

Join the global ILC community for cutting-edge science and networking.

🔗 ilc6vancouver.com

#ILCs #InnateImmunity #Immunology

Speaker List Updated: 21st Int'l Conference on #Innate #Immunity register today and join us in #Crete #Greece www.aegeanconferences.org/src/App/spea... #InnateImmunity