This review highlights #SREBP1 as a regulator of #cancer #MetabolicReprogramming, linking lipid/glucose metabolism to tumor growth, immunity, EMT, and therapy response, and explores SREBP1-targeted pathways as biomarkers and therapies.
#OpenAccess: doi.org/10.1016/j.ge...
GPR54 promotes progression & #MetabolicReprogramming in #NSCLC by enhancing dopa decarboxylase expression via the Gαq/11/PI3K/AKT/mTOR signaling pathway, underscoring its potential as both a #Biomarker & #TherapeuticTarget.
#OpenAccess: doi.org/10.1038/s413...
Here is an exciting weekly selection of #anticancer #therapy and #metabolicreprogramming! Enjoy (pardon, running a bit late this week 😅)
biomed.news/bims-meract/...
🙏 @biomednews.bsky.social
Targeting AKR1B1 inhibits metabolic reprogramming to reverse systemic therapy resistance in hepatocellular carcinoma
AKR1B1-driven #MetabolicReprogramming sustains #DrugResistance in #HCC, while #epalrestat restores sensitivity—positioning AKR1B1 as both #biomarker and therapeutic target to overcome systemic resistance. @tsinghuauniversity.bsky.social
#STTT: doi.org/10.1038/s413...
Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling in inflammatory bowel disease
Presenting a bioengineered #ExtracellularVesicle platform that combines surface checkpoint signaling with #miRNA-guided T-cell #MetabolicReprogramming of inflamed intestinal tissues via PD-1 and mitochondrial signaling for IBD.
#OpenAccess: doi.org/10.1038/s413...
This review examines #MetabolicReprogramming in #HeadAndNeckCancer, detailing glucose, amino acid, and #LipidPathway changes plus immune alterations, and highlights metabolic targeting as a promising strategy for therapy development.
#OpenAccess: doi.org/10.1016/j.ge...
#Hypoglycemia activates SRF/MRTF-A–mediated #MetabolicReprogramming in #neurons, triggering #urea accumulation and #AlzheimersDisease-like #neurodegeneration, while glucose restoration suppresses this pathway and reverses damage. #Diabetes
#OpenAccess #STTT: doi.org/10.1038/s413...
This review shows how #MetabolicReprogramming drives #ColorectalCancer initiation, progression, resistance & recurrence, detailing #TumorMicroenvironment crosstalk and signaling, while highlighting metabolic #biomarkers for early diagnosis.
#OpenAccess: doi.org/10.1016/j.ge...
Scientists report #MetabolicReprogramming drives #DrugResistance in #HCC; AKR1B1 is a key regulator tied to poor prognosis, while #Epalrestat restores response, marking AKR1B1 as a #biomarker. @tsinghuauniversity.bsky.social
#CoverPage in #STTT: doi.org/10.1038/s413...
This review highlights #MetabolicReprogramming in #ClearCellRenalCellCarcinoma, covering glucose, lipid, amino acid & mitochondrial pathways, and #multiomics insights for therapy against #tumor progression.
#OpenAccess: doi.org/10.1016/j.ge...
Scientists reveal that #hypoglycemia triggers reversible #neurodegeneration by activating neuron-intrinsic SRF/MRTF-A signaling, driving #MetabolicReprogramming & toxic byproduct buildup, while glucose refeeding switches off this pathway.
#OpenAccess #STTT: doi.org/10.1038/s413...
#OncostatinM induced by STAT5-activating #oncogenes triggers STAT-3-mediated proinflammatory signaling, resulting in #MetabolicReprogramming, enhanced cytokine secretion, and recruitment of #Immunosuppressive myeloid cells in blood malignancies.
#OpenAccess: doi.org/10.1038/s413...
TACC3, highly expressed in #Immunotherapy-resistant HCC tissues, promotes #MetabolicReprogramming by stabilizing ACSL4 transcripts, thus impairing tumor-killing activity of CD8+ T lymphocytes. @fudan-university.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
The FAK/Src kinase axis drives #MetabolicReprogramming by activating ACLY and ALDOA, which induce CDK7/9-mediated expression of DNA-replication and proliferation genes in primary and metastatic #ESCC cells. @pku1898.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#Review in #MedComm_Oncology
Targeting Metabolic Reprogramming in Tumor: From Mechanisms to Precision Immunotherapies doi.org/10.1002/mog2...
#ImmuneResponse #immunotherapy #MetabolicReprogramming #TME
His research integrates stable isotope tracing, mass spectrometry, and systems biology to increase translational relevance while reducing animal use. #CancerMetabolism #SystemsBiology #TranslationalResearch #MetabolicReprogramming
#Review in #MedComm
Trained Immunity in Health and Disease doi.org/10.1002/mco2...
#EpigeneticInheritance #Immunotherapy #ImmuneCell #MetabolicReprogramming #TrainedImmunity
Reviewing the cellular response & cross-talk in #LiverRepair & regeneration, the signaling pathways involved, & #MetabolicReprogramming of liver cells, with insights into innovations in #Diagnostic & therapeutic strategies.
#STTT #OpenAccess: doi.org/10.1038/s413...
🗣️New meeting announced
🟨 "Cancer Metabolism"🟨
📅 It's not too late to plan ahead
Submit abstracts by Jun 29 2026
⌛️Register by Sept 7 2026
🗓️Oct 6-8 2026
🖱️https://buff.ly/s88vxNH
#CancerMetabolism #Metabolism
#MetabolicReprogramming #CancerResearch
This review highlights the multifaceted mechanisms of #tumor #ImmuneEvasion, including checkpoint regulation, #TumorMicroenvironment dynamics & #MetabolicReprogramming, while discussing emerging #immunotherapies to curb resistance.
#STTT #OpenAccess: doi.org/10.1038/s413...
🍬Extracellular glucose triggers metabolic reprogramming of cultured human bronchial epithelial cells and indirect fibroblast activation
🔗https://buff.ly/45XpXXB
🥼 @lipiditsaso.bsky.social
#GlucoseMetabolism #Fibroblast #MetabolicReprogramming
The FAK/Src family kinase axis contributes to #MetabolicReprogramming by inducing the phosphorylation of ATP-citrate synthase and fructose-bisphosphate aldolase A, to promote #metastasis in #ESCC cells. #medsky @pku1898.bsky.social
#OpenAccess:
We are so thankful as we congratulate former lab member and outstanding scientist @npokorzynski.bsky.social on his appointment as Assistant Professor of Microbiology @oregonstate.edu #MetabolicReprogramming #proteolysis #antibioticsusceptibility microbiology.oregonstate.edu/directory/ni...
Describing the interplay between energy metabolism alterations & #ImmuneResponses in #HNSCC, the key molecular players, and the therapeutic relevance of targeting #MetabolicReprogramming in HNSCC. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
This review discusses #fattyacid-associated metabolic changes in #cancers and tumor–non-tumor cell interactions within the #TumorMicroenvironment, focusing on new targets for combination therapy with #MetabolicReprogramming and #immunotherapy. #medsky
#OpenAccess:
The methyltransferase SETDB1 catalyzes the dimethylation of CD147 at lysine 71 (CD147-K71me2), promoting tumor cell #apoptosis by upregulating FOSB expression and thereby inhibiting non-small cell lung cancer (#NSCLC) progression. #MetabolicReprogramming #ImmuneEvasion #medsky
Available online - the Review "The HIF axes in cancer: #angiogenesis, metabolism, and immune-modulation" from Karen Acuña-Pilarte and Mei Yee Koh.
#Hypoxia #HIF #TumorMicroenvironment #MetabolicReprogramming #Therapeutics
Read it here: authors.elsevier.com/sd/article/S...
The methyltransferase SETDB1 catalyzes the dimethylation of CD147 at lysine 71 (CD147-K71me2 ), tumor cell #apoptosis by upregulating FOSB expression toand thereby inhibiting non-small cell lung cancer (#NSCLC) progression. #MetabolicReprogramming #ImmuneEvasion #medsky
buff.ly/f8jjxwT
lncRNA ADAMTS9-AS2/let-7a-5p axis regulates metabolic reprogramming by targeting HK2 in oral submucous fibrosis-associated oral squamous cell carcinoma
The ADAMTS9-AS2/let-7a-5p axis modulates #MetabolicReprogramming in OSCC cells by suppressing #AerobicGlycolysis via targeting hexokinase 2 (HK2) to inhibit #OSCC progression. #WarburgEffect #OralCancer #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
🧬 Meet Dr. Hanane Hadj-Moussa
Discover how re-engineering acetyl-CoA metabolism could unlock constitutive healthy aging—only at #AGEAnnualMeeting2025!
🔗 bit.ly/4cJx8Gd
#HealthyAging #AcetylCoA #MetabolicReprogramming #MitochondriaMatters #AGE2025
