Mucosal vaccination in mice provides protection from diverse respiratory threats Traditional vaccines target specific pathogens, limiting their scope against diverse respiratory threats. We describe an intranasal liposomal formulation combining toll-like receptor (TLR) 4 and 7/8 l...

Link: www.science.org/doi/10.1126/...

#ELINE #EarlyLifeImmunity #Vaccines #MucosalImmunology #BCG #TrainedImmunity #Immunology

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To my friends who are @keystonesymposia.bsky.social #hematopoiesis and #myeloid meetings— please check out two talks from my group TOMORROW: Ruoqiong Cao on central #trainedimmunity Thursday morning and Arushana Maknojia unravels #microbiome dependent hematopoiesis in the pm! 🔥🔥🔥

The gut trains the bone marrow.
Microbial signals → trained immunity → systemic inflammation control. 🦠🦴
Discover the gut–bone marrow axis at
📍 Global Microbiome Congress 2026 | Boston
🗓 June 15–16, 2026
🔗 microbiomecongress.org
#TrainedImmunity #Microbiome #GMC2026

This latest review synthesizes evidence on the complex relationship between metabolic dysregulation and innate #Immune memory and proposes that targeting #TrainedImmunity may offer novel strategies for diabetes intervention. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Happy Friday! We're so thrilled to share our review on #trainedimmunity out in @elife.bsky.social today. We had a great time writing this. Honored to be included in the special issue of trained immunity. Always an absolute treat to write with @khannakm.bsky.social
elifesciences.org/articles/108...

Trained Immunity in Health and Disease Growth and timescale of medical publications on trained immunity and its related health and disease. This figure illustrates the number of published papers over time, from 2000 to 2025 (by August 14,...

#Review in #MedComm
Trained Immunity in Health and Disease doi.org/10.1002/mco2...

#EpigeneticInheritance #Immunotherapy #ImmuneCell #MetabolicReprogramming #TrainedImmunity

Challenge Specific Modulation of Responses to Adjuvant‐Induced Innate Immune Memory We utilised a commercially available adjuvant formulation to study the induction, maintenance, and consequences of innate immune memory. Using functional assays on bone marrow-derived innate cells, e...

🔚 Bottom line:
SAS induces a context-dependent innate immune memory that enhances protection but is reversible.
This opens doors to smarter vaccine design using adjuvants as immune trainers.

Read the full paper 👉 doi.org/10.1111/imm....
#Vaccines #TrainedImmunity
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🚨 New paper alert!

Our team at CIC bioGUNE has just published a new study in "Immunology" exploring how adjuvants can induce innate immune memory and reshape hematopoiesis.

Let’s dive in 👇

#InnateMemory #TrainedImmunity #Immunology
@anguitalab.bsky.social @cicbiogune.bsky.social

🧵1/6

Helminth infections affect host immune responses to viral infections and vaccines Abstract. Helminths are highly prevalent in many regions of the world. Due to the chronic nature of most helminth infections, these parasites are proficien

Check out this beautiful and comprehensive review by Juan Diego and Michael Schotsaert about "Helminth infections affect host immune responses to viral infections and vaccines" in ‪FemsMicroReview. #TrainedImmunity
@jgbd.bsky.social @mschotsaert.bsky.social
academic.oup.com/femsre/advan...

Frontiers | The underlying mechanism behind the different outcomes of COVID-19 in children and adults Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has affected hundreds of millions of people globally, resulting in millions of deaths. During this...

- 💉 as a layer of protection: #COVID19vaccination provides specific immunity against #Covid , further bolstering the protection afforded by #trainedimmunity & reducing the likelihood of infection or #Longcovid & the development of severe diseases.
@bmj.com
bmjpaedsopen.bmj.com/content/7/1/...

Trained immunity in chronic inflammatory diseases and cancer - Nature Reviews Immunology Besides its beneficial effects against infection, trained immunity has recently been implicated in inflammation-related disorders and is being exploited in cancer immunotherapy. These advances may ena...

The data show that induction of TRIM ( #Trainedimmunity) by certain vaccines confers broad beneficial effects that can protect beyond the target pathogen.

www.nature.com/articles/s41...
These insights suggest that prior #Covid19vaccines prevents overactivation of #innateimmune responses

Lactate trains immunity Understanding the mechanisms implicated in the establishment of trained immunity could aid the design of novel therapeutic approaches. By studying Bacille Calmette-Guerin (BCG) vaccination in a human ...

#Medsky🧪 #IDsky #immunosky #Publichealth Understanding the #Trainedimmunity, #inatedimmunity in infection @cellpress.bsky.social

www.cell.com/trends/immun...

journals.asm.org/doi/full/10....

www.ijmb.in/doi/IJMB/pdf...

www.researchgate.net/profile/Muha...

link.springer.com/article/10.1...

"High mobility group box-1 protein–mediated class II major histocompatibility complex transactivator superenhancers are critical for dendritic cell–trained immunity in acute-to-chronic progression of allograft rejection" by Sun et al. doi.org/10.1016/j.aj... #trainedimmunity #HMGB1

Lactate mediates the training of innate immune defenses – BioNews Central Lactate production by immune cells drives trained immunity via an epigenetic mechanism. ...

#Lactate production by #ImmuneCells drives #TrainedImmunity via an #EpigeneticMechanism.
#LacticAcid #Epigenetics

One of the most fascinating findings from our study is how NETs contribute to a form of trained immunity. After the second wave, infections with live bacteria triggered different immune responses—initially dampened, but later amplified (even 5 months later)
#trainedimmunity #NETs

Dissecting inflammation in the immunemetabolomic era - Cellular and Molecular Life Sciences The role of immune metabolism, specific metabolites and cell-intrinsic and -extrinsic metabolic states across the time course of an inflammatory response are emerging knowledge. Targeted and untargete...

Check out our new review discussing novel immunometabolic mechanisms underlying inflammation, metabolomic techniques and potential metabolite biomarkers of chronic inflammatory disease!

Special focus is on #efferocytosis #IL-10 and #trainedimmunity

link.springer.com/article/10.1...

9/9 I'd love to connect if you're interested in trained immunity, eosinophils, allergy, or infection-driven inflammation @science.org
#ScienceImmunology #PhDResearch #TrainedImmunity #Eosinophils #Asthma #Allergy #SkinInfection

Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary t...

New publication!!! Together Carlos Del Fresno Lab, we discussed how mucosal hashtag#vaccines based on trained immunity (TIbVs) work to prevent respiratory infections — including MV130, developed by
Inmunotek #AMR #TrainedImmunity #immunosky www.cell.com/trends/immun...

β-Glucan treatment reduces morbidity & mortality in Influenza A virus (IAV) infection though enhanced neutrophil recruitment via RoRγt+ T cells & type I IFN-driven granulopoiesis, generating a unique subset of IL-10-producing neutrophils.

#TrainedImmunity #β-Glucan #Neutrophils #InfluenzaA

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β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus - Nature Immunology Divangahi and colleagues report that β-glucan pretreatment before influenza A virus challenge can increase survival by inducing long-term reprogramming of neutrophils, promoting disease tolerance irre...

Nargis Khan and Maz Divangahi show that β-glucan reprograms HSCs in the bone marrow to generate ‘regulatory’ neutrophils (IL-10hi) which are required for promoting #diseasetolerance and lung tissue integrity against IAV challenge. [1/n]

www.nature.com/articles/s41...

#TrainedImmunity #RegNeuts

unbelievable #trainedimmunity talks this morning (day 2)at the #KSinnateimmune25.

loved Kari Nadeau's talk about allergy and TI!!

#Medsky🧪 #IDsky #oncosky #immunosky #publichealth Review the Pros & Cons of #Trainedimmunity in chronic inflammatory diseases and #cancer . Immunological memory has traditionally been considered an exclusive property of #adaptiveimmunity,

Here, we discuss IIM (in all its variants: #TrainedImmunity, #Tolerance, etc) in the context of host-microbiota interactions and as a mechanism of control of homeostasis and regulation of excessive inflammation

Paper alert:
Congratulations to PhD student, now Dr. Aryeh Solomon for this great work, published @elife.bsky.social

Can a BCG vaccine also protect from Gram-negative infection? #TrainedImmunity #BCG
Thanks also to long time collaborator Mihai Netea and other friends.

doi.org/10.7554/eLif...

Sina Bohnacker and Julia Esser-von Bieren identify key roles of heGDH in immune evasion, parasite chronicity, and tissue repair during helminth infections in this new study. Huge fan of Julia's work! #type2 #helminths #trainedimmunity #heGDH
www.science.org/doi/epdf/10.... [20/n]

Excited about the upcoming Innate Imm Memory Keystone meeting in Vancouver in Feb2025. Looking forward to sharing my postdoc work with the community, get some feedback and learn about cutting edge discoveries in #TrainedImmunity field. #LungresMacs ftw!

www.keystonesymposia.org/conferences/...

Hiya! I'll be at UVM (Burlington, VT) on this Friday (12/6) to give a talk for the VCIID seminar series and will talk about Resident #Macrophages in respiratory infections and #trainedimmunity. Would love to meet some macrophage enthusiasts and learn about your science. Esp trainees for lunch!

COVID caused cancer tumours to shrink in mice – new study | The-14 New research shows severe COVID can trigger immune responses that shrink cancer tumors in mice, offering hope for innovative treatments while stressing safety.

COVID caused cancer tumours to shrink in mice – new study
#Health #COVID19 #Cancer #CancerResearch #Tumours #COVIDAndCancer #Immunotherapy #ScientificDiscovery #CancerTreatment #ImmuneSystem #MedicalBreakthrough #TrainedImmunity #HealthResearch
the-14.com/covid-caused...

Back to working full-time on #InnateImmuneMemory, so I'll start posting papers (mostly new, but also older ones that I re-read) on the topic. Hope this helps everyone (me too 😅) keeping up-to-date with this fast-growing field 😄

#TrainedImmunity #Tolerance #InnateImmunity #Immunity

BCG immunization induces CX3CR1hi effector memory T cells to provide cross-protection via IFN-γ-mediated trained immunity - Nature Immunology Divangahi and colleagues identify a mechanism of heterologous immunity by BCG involving cross-talk between conventional memory T cells and innate memory cells against influenza A virus infection’.

Kim and Maz Divangahi team show that an iv BCG vaccination in mice provide protection against subsequent IAV infection via CX3CR1hi CD4+ T cells in blood and lungs. IFNg was able to enhance AM-induced antiviral immunity. #TrainedImmunity [16/n]

www.nature.com/articles/s41...