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This is the biopsy of a 62yo Hispanic female with hematuria and proteinuria. What is this stain and what is the diagnosis?

#DiagnoseThis #nephtwitter #pathtwitter #renal #kidneypath

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(1/2) A case of florid ALECT2 type amyloidosis. This is a Hispanic patient who had not seen a physician in several years. Leukocyte chemotactic factor 2 type amyloidosis (ALECT2) is a form of amyloid of unknown etiology.  #renal #pathtwitter #kidneypath #underthescope

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Go to isupweb.net to see more of the case! #gupath #pathtwitter #ISUPCOTM

Authors: Dheeraj Chinnam, MD; Muhammad T. Idrees, MD, Indiana University School of Medicine, Indianapolis, IN, USA

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(1/3) A case of active lupus nephritis in a limited sample. Only renal medulla was present for IF. Two glomeruli total were present for LM and paraffin IF was performed, which demonstrated near "full house" staining.

#GlomGoals #biopsyadequacy #pathtwitter #renaltwitter

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(1/2) A case of lambda light chain cast nephropathy in a limited sample. The entire biopsy consisted of renal medulla.

#GlomGoals #biopsyadequacy #renaltwitter #pathtwitter

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60’s male, parotid mass
Dx: Warthin tumor
📸macro: cystic-solid mass, note layering of cystic contents for gross-micro correlate [arrow]
📸low mag overview [arrow for gross-micro reference]
📸papillary projections w/lymphoid stroma
📸bilayered oncocytic epithelium

#PathSky #Otosky #PathTwitter #ENTsky

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Go to isupweb.net to see more of the case! #gupath #pathtwitter #ISUPCOTM

Authors: Dong Ren, MD, PhD; Robert Edwards, MD, PhD, University of California-Irvine Medical Center, Orange, CA, USA

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🆕 New publication alert 🚨
PC-RPLND from patients with TGCTs: key morphologic variants, diagnostic pitfalls, and clinical impact—read & share!

🔗 www.sciencedirect.com/science/arti...

#pathtwitter #pathX #gupath #TGCT #IUPathology #indianapath @iupathology

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40’s FM parotid mass

Dx: mucoepidermoid ca

📸 macro: ill defined borders, largely solid, focal cystic (arrowhead). Parotid node (solid arrow) and skel.muscle (open arrow)
📸 touch prep: clusters polygonal cells w/dense cytoplasm
📸 scan mag appearance

#PathSky #ENTSky #Radsky #Otosky #PathTwitter

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The RPS is inviting you to a webinar
Spectrum of Transplant Rejection: Towards the Implementation of Activity and Chronicity Indices
Tuesday, December 2, 2025
8:00 AM PST / 11:00 AM EST / 5:00 PM CET
For more info & to register: renalpathsoc.org/event-6445938
#renalpath #PathTwitter #nephrology

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Join RPS-GlomCon Renal Pathology Webinar Series
Update on CKDu/CINAC
Speaker: Cynthia Nast, MD
Date: November 30, 2025
Webinar info: renalpathsoc.org/event-6113942
#renalpath #PathTwitter
@glomcon.org

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#GrandRounds are an opportunity for our residents and fellows to practice their presentation skills while advancing their knowledge on a chosen topic in their specialty. We've had a great group this semester- we can't wait to see what's in store for the spring!
#PathTwitter

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Mid-30’s FM w/progressive conductive hearing loss. Clin dx: otosclerosis

Intraop: stapes fixed, remainder of ossicular chain mobile.

📸: stapes with remodeling, transected above footplate
📸: evolving pseudocyst w/i the articular surface (reactive)

#PathSky #ENTpath #PathTwitter #EmoryPathology

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Preview
Uromigos on X: "The UromigosLive 2025 meeting presents #UromigosShorts videos on GU Oncology topics. The videos with the most views win a prize at #UromigosLive November 7-8th in Nashville, TN. Below, Dr. David Aggen discusses : Variant Histology Bladder Cancer. https://t.co/h3DFbgnz3G" / X The UromigosLive 2025 meeting presents #UromigosShorts videos on GU Oncology topics. The videos with the most views win a prize at #UromigosLive November 7-8th in Nashville, TN. Below, Dr. David Aggen discusses : Variant Histology Bladder Cancer. https://t.co/h3DFbgnz3G

🎶 Wondering how to tackle variant histologies in bladder cancer?

🎧 Watch here ⬇️

x.com/uromigos/sta...

@Uromigos @Dr_Aggen @BladderCancerUS
#BladderCancer #UroOnc #GUonc #PathTwitter

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📸Transverse section through the cricoarytenoid joint (CAJ) of the larynx, a true synovial joint. Arrows delineate joint space
📸 Same, just higher mag
📸 Generally surfaced by fibrocartilage (but may be mixed). Synovium present
📸 Synovial lining

#PathSky #ENTPath #PathTwitter
#EmoryPathology

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Squamous cell carcinoma of the edentulous alveolar ridge and palate. Cut surface (ms=maxillary sinus; nc=nasal cavity); corresponding low mag image; endophytic (arrow) with cystic cuniculatum-like growth; additional cystic change in scca.

#PathSky #ENTPath #HeadNeckPath #OralPath #PathTwitter

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Primary Ciliary Dyskinesia is an inherited condition marked by abnormal function of motile cilia where chronic respiratory infections and bronchiectasis are common.

Let's explore how this case from Drs. David Meyerholz and Douglas Hornick guides future research. #PathTwitter

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Go to isupweb.net to see more of the case! #gupath #pathtwitter #ISUPCOTM

Authors: Lisha Wang, MD, PhD, Yue Sun, MD; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

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Visiting Joel with Dr. Archana Gudipati | Episode 4
Visiting Joel with Dr. Archana Gudipati | Episode 4 YouTube video by Arkana Laboratories

The final episode of Visiting Joel with Dr. Archana Gudipati is here! In this episode, we reflect on Dr. Gudipati's visit to Arkana and what she learned while here. #pathx #pathtwitter #renal

www.youtube.com/watch?v=xfTQ...

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Taking T-Acute Lymphoblastic Leukemia (T-ALL) a ‘NOTCH’ higher (1/n): #AMPtutorials #AMPath24 #molpath
#pathtwitter #pathX #path2path #PathX
T-ALL is a hematological malignancy characterized by the infiltration of bone marrow with hematopoietic cells expressing immature T-cell markers.

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Lytic lesion of mandible, prior extraction site; years ago.

Myospherulosis represents altered RBCs in cyst-like spaces, surrounded by fibrosis. At high magnification, note the pigmented spherical bodies (‘bag of marbles’). Potentially a fungal mimic ➡️ PAS/GMS neg.

#PathSky #OralPath #PathTwitter

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Challenge yourself to new cyto challenges!
4 questions in each module. Can you do it??
⬇️⬇️⬇️
🍤Pancreas
pathologynotebook.com/cytopancreas-6
🫁 Lung
pathologynotebook.com/cytolung-6
🚽 Urinary
pathologynotebook.com/cytourinary-6
⬆️⬆️⬆️
#CytoPath #PathTwitter #Pathology #PathSky

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✅#1 & Bonus: Endocervical Adenocarcinoma in situ (AIS)
cells in strips & rosettes
nuclear feathering pseudostratification
chromatin is coarse, evenly distributed
cytoplasm diminished, finely vacuolated, with unclear borders
background clean
#PathSky #GynPath #PathTwitter #CytoPath #Pathology

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✅#2 Answer: HSIL extending into glands
clues to a squamous origin include central spindling or whorling with flattening of the nuclei at the periphery
#PathSky #GynPath #PathTwitter #CytoPath #Pathology

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Read the explanation below.

Then challenge yourself to new cyto challenges!
4 questions each module. Can you do it?
⬇️⬇️⬇️
🍤Pancreas
pathologynotebook.com/cytopancreas-6
🫁 Lung
pathologynotebook.com/cytolung-6
🚽 Urinary
pathologynotebook.com/cytourinary-6
⬆️⬆️⬆️
#CytoPath #PathTwitter #Pathology #PathSky

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Bonus: What is your interpretation?
#PathSky #PathTwitter

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#2 of 2: Pap from 25-year-old female.

What is your interpretation?
A) NILM
B) HSIL
C) AIS
#PathSky #PathTwitter #CytoPath #Pathology

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#1 of 2: Pap from a 30-year-old female.

What is your interpretation?
A) NILM
B) HSIL
C) AIS
#CytoPath #Pathology
#PathSky #PathTwitter

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Challenge yourself to some extra cyto!
4 questions in each module. Can you do it??
⬇️⬇️⬇️
🍤Pancreas
pathologynotebook.com/cytopancreas-4
🫁 Lung
pathologynotebook.com/cytolung-4
🚽 Urinary
pathologynotebook.com/cytourinary-4
⬆️⬆️⬆️
#CytoPath #PathTwitter #Pathology #PathSky

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✅#1 & #3: *ABUNDANT* colloid is considered benign and satisfactory for evaluation, even if the “6 groups of 10” criterion of adequacy is not met.
#CytoPath #PathTwitter #Pathology #PathSky

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