Squamous cell carcinoma of the edentulous alveolar ridge and palate. Cut surface (ms=maxillary sinus; nc=nasal cavity); corresponding low mag image; endophytic (arrow) with cystic cuniculatum-like growth; additional cystic change in scca.
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Lytic lesion of mandible, prior extraction site; years ago.
Myospherulosis represents altered RBCs in cyst-like spaces, surrounded by fibrosis. At high magnification, note the pigmented spherical bodies (‘bag of marbles’). Potentially a fungal mimic ➡️ PAS/GMS neg.
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Submandibular sialolith is a gross-only specimen for us. However…the interesting surface texture piqued my interest. Intact appearance, sectioned, faxitron (in our lab) and low mag histology with arrows highlighting the textured region.
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Will find SNP tissue (arrows in these two low magnification examples) near fungiform, foliate and/or circumvallate papillae of the tongue.
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Image of the Week!
Submitted by: Fernando Tenorio-Rocha, Ph.D.
Directory Profile: buff.ly/Bi3TZTx
Subspecialty: Oral and maxillofacial pathology
Diagnosis: Odontogenic keratocyst
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Idiopathic gingival papillokeratosis with crypt formation.
Uncommon. Generally located along anterior maxillary gingiva in young people. Asymptomatic plaque(s), usually bilateral and white in color. No known risk of transformation.
PMID: 28089460
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✅ Verrucous Carcinoma
✅Characteristic broad, "pushing" invasive front combined with deceptively bland cytology
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🔬 tumourclassification.iarc.who.int/Viewer/Index...
❌ Low/High Grade Dysplasia: Defined by atypia!
Dysplasia requires intrinsic cytologic atypia (nuclear enlargement relative to cytoplasm, hyperchromasia, pleomorphism, increased/abnormal mitoses) PLUS architectural disarray (loss of maturation/polarity)
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❌ Reactive Hyperplasia (e.g., Pseudoepitheliomatous)
Reactive SCC mimic
Irregular downward growth, often pointed/spiky rete
Lacks intrinsic cytologic atypia (reactive changes okay)
Underlying inflammation, necrosis, or granular cell tumor (characteristic)
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Laryngeal biopsy. What would you call this squamous cell proliferation?
🤔
A) hyperplasia
B) dysplasia
C) carcinoma
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🔬 tumourclassification.iarc.who.int/Viewer/Index...
✅Necrotizing sialometaplasia
squamous metaplasia of ductal epithelium
necrosis of salivary acini
pseudoepitheliomatous hyerplasia
lobular architecture is maintained (most important!!)
most commonly occurs in the minor salivary glands of the hard palate
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Painful palatal ulcer.
What do you think?🧐
A) Benign
B) Malignant
Could it be #TooFarToDiagnose??
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🔬 tumourclassification.iarc.who.int/Viewer/Index...
Image of the Week!
Submitted by: Fabio L. Coracin, M.S., Ph.D., D.D.S.
Directory Profile: buff.ly/6W2pxSO
Subspecialty: Oral and maxillofacial pathology
Diagnosis: Mucoepidermoid carcinoma (MEC)
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