Image describing the J-PAL North America training titled ARTEMIS, June 22-26, 2026. Transcribed Text: FREE TRAINING Advanced Research Training in Evaluation, Methods, and Impact Studies (ARTEMIS) A free training opportunity on rigorous evaluation methods for early-career researchers. This opportunity offers: 📈 Technical training 🧠 Expert mentorship 💰 Pathways to funding Training dates June 22-26, 2026 Apply by April 8! Link in post J-PAL Abdul Latif Jameel Poverty Action Lab NORTH AMERICA

Don't design your first #RCT alone. 🧠 Join ARTEMIS for a week-long summer institute in Dedham, MA, followed by 6 months of expert mentorship from J-PAL staff to help move your idea toward funding.
📍 June 22-26, 2026
👉 Deadline: April 8
🔗 https://j-p.al/ARTEMIS

Comparison of Uncemented and Hybrid Hip Arthroplasty: #Protocol for a Brazilian #RCT #ClinicalTrial Background: Total hip arthroplasty is a highly successful procedure for treating hip arthritis, improving patients’ pain, function, and quality of life (QoL). Scarce publications on total hip arthroplasty performance using Brazilian-manufactured materials report results comparable to those from other countries. Objective: The aim of this #Study is to compare the clinical, radiographic, functional, pain, and QoL outcomes of patients who underwent surgery with a national hybrid prosthesis (with femoral cementation) versus patients who underwent surgery with a national uncemented prosthesis. Methods: This #Study is a single-center, single-surgeon, single-approach, pragmatic, double-blinded, and prospective randomized trial. A total of 120 patients will be enrolled and randomly allocated in a 1:1 ratio to 2 groups: the hybrid group and the uncemented group. The incidence of complications (during and after surgery) and the restoration of normal anatomical parameters on postoperative radiographs will be assessed using radiographic parameters. Participants’ QoL, joint mobility, function, and satisfaction will be evaluated using the 12-Item Short Form Health Survey version 2 questionnaire, hip range of motion, the Harris Hip Score, and a numeric rating scale. Prosthesis survival will be analyzed using the annual revision surgery rate from 1 to 5 years, and up to 10 years. Results: The project did not receive external funding. Data collection began in October 2024 and is ongoing, with completion expected in December 2029. As of April 2025, 72 participants have been enrolled. Preliminary data analysis has been initiated and is ongoing. The first results are expected to be published in the first half of 2026. Conclusions: This #Study is a pragmatic clinical trial that uses blinding to evaluate national implants for both hybrid and uncemented hip arthroplasty. Successful completion of this #Study may provide clinical evidence on the performance of national implants and identify a preferred implant construct (hybrid or uncemented), if any, for hip replacement in Brazil. Trial Registration: Brazilian Registry of Clinical Trials RBR-263nf22; https://ensaiosclinicos.gov.br/rg/RBR-263nf22 International Registered Report Identifier (IRRID): DERR1-10.2196/79721

JMIR Res Protocols: Comparison of Uncemented and Hybrid Hip Arthroplasty: #Protocol for a Brazilian #RCT #ClinicalTrial

Group antenatal care: findings from a pilot randomised controlled trial of REACH Pregnancy Circles Pilot and Feasibility Studies - Antenatal care has the potential to impact positively on maternal and child outcomes, but traditional models of care in the UK have been shown to have limitations...

This paper describes the findings from a pilot randomised controlled trial of REACH Pregnancy Circles: ow.ly/ZnX150Y5zWF #antenatalcare #pilottrial #RCT #pregnancycare #groupcare

Real-World Validation of Arkangel AI, a Conversational Agent for Real-Time Evidence-Based #Medical Question Answering: #RCT #ClinicalTrial Date Submitted: Feb 17, 2026. Open Peer Review Period: Mar 11, 2026 - May 6, 2026.

Reminder>> Real-World Validation of Arkangel AI, a Conversational Agent for Real-Time Evidence-Based #Medical Question Answering: #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

A clear sunny day sits between two stormy fronts, and it’s impossible not to heed its call. #Publicrightofway #definitivemap #rct #pontypridd #nature #walking #routes #footpath

Reminder>> A Fully Remote Serious #Game for Cognitive Control Training in Major Depressive Disorder: A #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

WPGN is LIVE NOW!
Life is a RollerCoaster! Let's Tycoon! Checking out more of the DLC parks and having a cozy vibe. Find your seat in the theater at www.twitch.tv/birchtwigs

#WPGN #RCT #OpenRCT #RollerCoaster #Chill

Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid - PubMed With the possible exception of blinding of data analysts, use of "probably yes" and "probably no" instead of "unclear" may enhance the assessment of blinding in trials.

Looking at an #RCT to decide who among #patients, #clinicians, data collectors, et al is #blinded and it’s not clear and explicit? Happens often. Fortunately, almost always enough clues that if you follow instructions in this paper you will make the right inference.
pubmed.ncbi.nlm.nih.gov/22200346/

Reminder>> Immersive 3D Simulation vs. Physical Models in Training Novices for Laser-based Endourological Procedures - #Research #Protocol for a #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

Real-World Validation of Arkangel AI, a Conversational Agent for Real-Time Evidence-Based #Medical Question Answering: #RCT #ClinicalTrial Date Submitted: Feb 17, 2026. Open Peer Review Period: Mar 11, 2026 - May 6, 2026.

Real-World Validation of Arkangel AI, a Conversational Agent for Real-Time Evidence-Based #Medical Question Answering: #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

Real-Time Pricing to Reduce Electricity Use in the United States | The Abdul Latif Jameel Poverty Action Lab During periods of high electricity use that strain the grid, electricity customers do not have any reason to conserve because they pay a fixed price per kilowatt hour of power. In this study, the rese...

Periods of high electricity use⚡ strain the grid. One #RCT found that real-time pricing could be a promising strategy to conserve electricity and reduce strain: www.povertyactionlab.org/evaluation/real-time-pri...

Clinical Efficacy Evaluation of Tuina Combined Medicated Oil in the Treatment of Nonspecific Low Back Pain: #Protocol for a #RCT #ClinicalTrial Background: Nonspecific low back pain (NSLBP) is a significant global public health concern that affects the health and well-being of individuals across different age groups, limiting their daily activities and reducing their quality of life. As Tuina (Chinese therapeutic massage) therapy and medicated oil are widely used in China, it is necessary to design a randomized clinical trial to assess the effectiveness of Tuina combined medicated oil (TNO) in treating NSLBP. Objective: This #Study aims to evaluate the efficacy and safety of Tuina therapy combined with medicated oil in treating NSLBP. Methods: One hundred participants will be enrolled and randomly allocated to either a TNO group (n=50) or a Tuina combined water group (n=50). Treatment will last for 4 weeks, with sessions 3 times a week, followed by a 4-week follow-up. The visual analog scale score is the primary outcome; secondary outcomes include the evaluation of treatment Japanese Orthopaedic Association scores, infrared thermography, muscle tension tests, and tenderness scores. All adverse reactions will be recorded. Results: The trial commenced in June 2023 and is expected to conclude in September 2025. In June 2025, key preliminary steps were completed, and the ethical review and clinical trial registration were concluded. Recruitment is proceeding as planned, with 100 participants enrolled to date. Data collection is underway, while formal data analysis has not yet commenced. Conclusions: The project’s purpose is to evaluate the effectiveness of TNO in alleviating pain and improving lumbar function in patients with NSLBP. Trial Registration: ChiCTR ChiCTR2300076144; https://www.chictr.org.cn/hvshowproject.html?id=247247 International Registered Report Identifier (IRRID): DERR1-10.2196/81887

JMIR Res Protocols: Clinical Efficacy Evaluation of Tuina Combined Medicated Oil in the Treatment of Nonspecific Low Back Pain: #Protocol for a #RCT #ClinicalTrial

RCT - Pierre Mignoni de retour au Campus RCT : quel impact pour le choc face au Stade Français ? Pierre Mignoni est de retour au Campus RCT après trois semaines d’absence pour raisons de santé.

Pierre Mignoni de retour au Campus RCT avant le choc face au Stade Français #RCT #PierreMignoni #Top14 presse83.fr/2026/03/11/p...

A Fully Remote Serious #Game for Cognitive Control Training in Major Depressive Disorder: A #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

Virtual Reality for the Management of #postoperative Pain and Anxiety in Children and Adolescents Undergoing Nuss Repair of Pectus Excavatum: #rct Background: Virtual reality (VR) is a novel technology with implications for pain and sensory processing. VR may serve as a novel, scalable method to deliver clinically validated therapy for pain management as an alternative or adjunct to opioids for acute pain. Given that psychological factors and pain perception are both components of #postoperative pain, it may also be beneficial to incorporate modalities that decrease anxiety, such as active relaxation and guided meditation with VR. Unfortunately, these therapies are not widely available due to multiple barriers. VR has the potential to deliver pain-reducing, psychologically based therapy to children, thereby enhancing multimodal analgesia and potentially decreasing opioid use. This #study investigates the role of VR in reducing pain and anxiety after #surgery. Given the substantial risks associated with opioid use, particularly in younger populations, alternative pain management strategies are crucial. Objective: The primary aim of this #study was to evaluate the efficacy of VR as a nonpharmacological intervention for managing #postoperative pain intensity, pain unpleasantness, anxiety, and opioid use in children and adolescents undergoing Nuss repair of pectus excavatum. Methods: A single-center, prospective, randomized, controlled trial was conducted at a tertiary care children’s hospital and research center. Ninety children and adolescents (8-18 y) undergoing the Nuss procedure were randomized to guided relaxation or mindfulness VR (n=30) and distraction-based gaming VR (n=30), combined to form the VR group (n=60), and a control group using a passive 360° video (n=30). #patients received a 10-minute session on #postoperative days 1 and 2. Pain intensity, pain unpleasantness, and anxiety were evaluated before and 0-, 15-, and 30-minute post-session. In-hospital pain scores, anxiety scores, and opioid use were collected. Results: Children and adolescents who participated in VR reported a significantly greater decrease in pain intensity from baseline (0.41, SE 0.23) compared with those in the 360° video group at 30 minutes (=.04) before multiplicity adjustment but not after multiplicity adjustment. There were no significant differences in pain scores or opioid use between the VR and control groups on #postoperative day 1 or 2, nor were there changes in pain unpleasantness or anxiety at any time after the intervention. Conclusions: Daily, 10-minute VR sessions provided some trends toward transient analgesic and anxiolytic effects, albeit none that were statistically significant. VR did not significantly decrease overall pain scores or opioid usage, possibly due to the limited intervention duration and high standardized opioid use. Future studies should investigate extended and more frequent VR sessions and the integration of VR with other therapeutic modalities. Trial Registration: ClinicalTrials.gov NCT04351776; https://clinicaltrials.gov/#study/NCT04351776

New JMIR Periop Med: Virtual Reality for the Management of #postoperative Pain and Anxiety in Children and Adolescents Undergoing Nuss Repair of Pectus Excavatum: #rct

Learn about fair tests of treatment through history, in the #TrialsTuesday series from
@jameslindlibrary.bsky.social

#HistoryOfMedicine #EBM #EBHC #RCT

Immersive 3D Simulation vs. Physical Models in Training Novices for Laser-based Endourological Procedures - #Research #Protocol for a #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

#EPITUBE: Does prophylactic #norepinephrine reduce post-induction severe hypotension in cardiac surgery? This #RCT by Gaillard et al. found no reduction in severe hypotension, #AKI, ventilatory duration, or ICU length of stay vs on-demand ephedrine.

bjanaesthesia.org/article/S0007-0912(25)00795-0/

Reminder>> Effects of breathing exercises on #Pain, disability, range of motion and muscle endurance in #Patients with chronic low back #Pain, a #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

A long sleeveless cream satin ballgown decorated with gold trelliswork and floral embroidery

A black and white photograph of women embroiderers from the 1940s working for Norman Hartnell. Two women are working at a frame in front of them beading a piece of silk

An embroidery sample showing a spray of flowers created by Hartnell’s embroiderers for the coronation gown of Queen Elizabeth II

Happy International Women’s Day! Acknowledging the hands of countless women in the needle trades through the lens of the women in Norman Hartnell’s embroidery workroom. Their legacy survives in the glittering gowns they embellished. Dress 1950s #RCT #FashionHistory 🗃️🪡

Key study of Grail’s cancer detection test fails in setback for company Grail's blood test for detecting cancer early failed to meet its main goal in a giant study being conducted with England’s NHS, the company said.

Company, new #tests for early #CancerDetection to decrease late-stage #cancer and #mortality sold 185k in 2025 at $1k a crack. Problem: just completed #RCT no benefit either outcome. Latest evidence cancer screening limitations, need to wait for evidence of benefit.

www.statnews.com/2026/02/19/g...

Reminder>> Acupuncture and related therapies for post-infectious cough: #Protocol for a systematic review and meta-analysis of #RCT #ClinicalTrials (preprint) #openscience #PeerReviewMe #PlanP

New #RCT showing a prophylactic infusion of #noradrenaline was not superior to rescue #ephedrine at preventing severe hypotension in #cardiacsurgery

www.bjanaesthesia.org/article/S0007-0912(25)00...

Integrative Traditional East Asian #Medicine-Based Adjunctive Therapies for Prostate #Cancer #Patients Undergoing Standard #Cancer Treatment: #Protocol for a Systematic Review and Meta-Analysis of #RCT #ClinicalTrials Date Submitted: Feb 25, 2026. Open Peer Review Period: Mar 3, 2026 - Apr 28, 2026.

Reminder>> Integrative Traditional East Asian #Medicine-Based Adjunctive Therapies for Prostate #Cancer #Patients Undergoing Standard #Cancer Treatment: #Protocol for a Systematic Review and Meta-Analysis of #RCT #ClinicalTrials (preprint) #openscience #PeerReviewMe #PlanP

Impact of the Population Medicine Multimorbidity Intervention in Xishui County (POPMIX) on People at High Risk for Chronic Obstructive Pulmonary Disease Who Experience Mental Health Symptoms: #Protocol for the POPMIX-MH Cluster #RCT #ClinicalTrial Background: Chronic obstructive pulmonary disease (COPD) and mental health conditions represent intersecting public health challenges, especially in resource-limited rural China. Existing care models often neglect the psychosocial needs of populations at high risk for COPD, resulting in limited effectiveness of prevention and management strategies. This #Study evaluates an integrated intervention designed to improve both mental and physical health outcomes among high-COPD-risk individuals with mental health symptoms, using a population medicine framework. Objective: This #Study aims to evaluate the effect of an integrated, population medicine–based multimorbidity intervention package among high-COPD-risk individuals with mental health symptoms in Xishui County, Guizhou Province, China. Methods: We are conducting a 12-month, 2-arm cluster #RCT #ClinicalTrial across 26 townships in Xishui County, Guizhou, China. A total of 44,000 residents aged ≥35 years were screened using the Chronic Obstructive Pulmonary Disease Screening Questionnaire, identifying 10,000 individuals at high risk of COPD. Among them, 3807 individuals with Warwick-Edinburgh Mental Well-Being Scale scores below 45 were enrolled as participants. Intervention components include #Digital cognitive behavioral therapy–based mental health support, community screening, chronic disease management, patient education, #Digital follow-up, and team-based care. The primary outcomes are depressive symptoms (9-item Patient Health Questionnaire), anxiety symptoms (7-item General Anxiety Disorder), and mental well-being (Warwick-Edinburgh Mental Well-Being Scale). Secondary outcomes are control of chronic diseases, physiological and functional indicators such as lung function, health-related quality of life, mental and behavioral health, health care utilization, knowledge of COPD and asthma, productivity loss, and care cascade indicators for chronic conditions. Results: Data collection for the POPMIX-MH trial began in June 2024. Baseline, 3-month, and 6-month assessments have been completed, and the 12-month follow-up assessments are planned to be completed in March 2026. Conclusions: This #Study is the first to integrate psychological support, chronic disease management, and community-based screening into a single scalable intervention package targeting multimorbidity in China. It tests the feasibility of applying population medicine principles, emphasizing integrated, preventive, and population-level care, within primary care systems in low-resource settings. By targeting both mental and physical health, it redefines chronic care beyond traditional organ-specific approaches. Trial Registration: ClinicalTrials.gov NCT06458218; https://clinicaltrials.gov/ct2/show/NCT06458218

JMIR Res Protocols: Impact of the Population Medicine Multimorbidity Intervention in Xishui County (POPMIX) on People at High Risk for Chronic Obstructive Pulmonary Disease Who Experience Mental Health Symptoms: #Protocol for the POPMIX-MH Cluster #RCT #ClinicalTrial

If there is a time of year to attempt discovery of a difficult or hidden pathway – it is now – when the winter branches are at their barest, and the spring is still too new too have powered up the thick growth of bracken and brambles that render unkept pathways invisible. #pathways #rct #pontypridd

What should we prioritise next at Calfaria Hub, Treorchy?

A Early support
B Carers
C Reduce isolation
D Practical advice
E Young people

Reply with your letter 👇
Results Next Saturday
#FeedbackFriday #RCT #Treorchy

Our friends at New Horizons Mental Health are running a free VR Mindfulness study.
Curious?

Come try the VR first at the Calfaria Wellbeing & Wellness Hub, Treorchy every Wednesday 10am–12pm before signing up.
Free to take part.

📋 form.jotform.com/251594113118...
#MentalHealth #Treorchy #RCT

Effects of breathing exercises on #Pain, disability, range of motion and muscle endurance in #Patients with chronic low back #Pain, a #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

Thank you Interlink RCT for the opportunity to speak at the Connecting Rhondda Communities event and share the work happening at the Calfaria Wellbeing & Wellness Hub, Treorchy.
Great to connect with partners working together to support wellbeing across the Rhondda.
#ConnectingRhondda #Treorchy #RCT