This review highlights #Organcrosstalk as a regulator of #homeostasis, integrating brain, heart, and gut axes with insights into #signalingpathways, technologies, and therapies, advocating for network-driven models and personalized strategies.

#STTT: doi.org/10.1038/s413...

Researchers explore #CytokineStorm pathogenesis, detailing key #SignalingPathways, immune cell dysregulation, and #OrganInjury, while discussing emerging targeted therapies and multidisciplinary clinical management strategies.

#OpenAccess in #STTT: doi.org/10.1038/s413...

This review summarizes the molecular mechanisms and key #signalingpathways driving #CytokineStorm, highlights its role in severe inflammatory diseases like #FulminantMyocarditis, #ARDS, HLH, and CRS, and discusses emerging therapeutic strategies.

#STTT: doi.org/10.1038/s413...

Researchers summarize key #signalingpathways driving #HCC progression & highlight advances in immune-based combination therapies, emphasizing emerging strategies and #biomarkers that promise to transform HCC treatment. @fudan-university.bsky.social

#STTT: doi.org/10.1038/s413...

This review summarizes recent advances in the #ImmunologicalSynapse, detailing its structure, #SignalingPathways and highlights how its dysregulation drives disease while revealing #TherapeuticTargets for immune modulation. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

This review outlines the molecular mechanisms, #SignalingPathways, and regulatory factors underlying the therapeutic effects of #MesenchymalStemCells, highlights recent #ClinicalStudies, challenges and future perspectives. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

This #MostRead review describes the functions of PI3K #SignalingPathways, how PIK3CA mutations rewire #CellSignaling, metabolism, & the #TumorMicroenvironment, & discusses therapeutic strategies for PIK3CA-mutant tumors. @cwrufarm.bsky.social #medsky

#OpenAccess:

This #MostRead review describes the functions of PI3K #SignalingPathways, how PIK3CA mutations rewire #CellSignaling, metabolism, & the #TumorMicroenvironment, & discusses therapeutic strategies for PIK3CA-mutant tumors. @cwrufarm.bsky.social #medsky
#OpenAccess:
buff.ly/Ev5GDjp

Oncogenic activation of PIK3CA in cancers: Emerging targeted therapies in precision oncology

This review discusses the functions of PI3K #SignalingPathways, describes how PIK3CA mutations rewire #CellSignaling, metabolism, & the #TumorMicroenvironment, & therapeutic strategies for PIK3CA-mutant tumors.

#OpenAccess: www.sciencedirect.com/science/arti...