Out now in @@cp-cellreports.bsky.social: @UCSanDiego.bsky.social researchers reveal how a single receptor in #bloodvessels can trigger either harmful #inflammation or protective healing, solving a longstanding molecular mystery #biochemistry #research #cellsignaling
PP1γ2 is key to sperm maturation and motility in tree shrews. This study shows PKA activates SRC, which then inhibits PP1γ2-mediated Ser/Thr phosphatase activity, boosting caudal sperm motility #CellSignaling
onlinelibrary.wiley.com/doi/10.1002/...
#Spectrin coordinates cell shape and signaling essential for epidermal differentiation, say Arad Soffer, Aishwarya Bhosale, Carien M. Niessen, Chen Luxenburg, Matthias Rübsam @unicologne.bsky.social and colleagues: rupress.org/jcb/article/...
#CellSignaling #Development #Cytoskeleton
Cullin-3 adaptor SHKBP1 inhibits SQSTM1/p62 oligomerization and Keap1 sequestration. New study from Lin Luan, Jeremy Baskin @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social: rupress.org/jcb/article/...
#CellSignaling #Biochemistry
AMP-Glo™ Assay: sensitive luminescent detection of adenosine monophosphate for enzyme activity studies & drug discovery. Z' values >0.7 for high-throughput screening of phosphodiesterases, DNA ligases, aminoacyl-tRNA synthetase
https://ow.ly/fAcM50Y1GuL
#CellSignaling #DrugDiscovery #LifeSciences
Soffer, Bhosale, Niessen, Luxenburg, Rübsam @unicologne.bsky.social et al. identify #spectrin as a central component of epithelial cortical #actomyosin networks to control cortex mechanics and signaling. rupress.org/jcb/article/...
#CellSignaling #Cytoskeleton #Development
In @jcb.org, Soffer, Bhosale, Niessen, Luxenburg, Rübsam @unicologne.bsky.social et al. identify #spectrin as a central component of epithelial cortical #actomyosin networks to control cortex mechanics and signaling. rupress.org/jcb/article/...
#CellSignaling #Cytoskeleton #Development
Save 20% on Phospho-Specific Antibodies This February
Convenient 20 µL vials available with next-day delivery.
Browse and order now: https://bit.ly/4rAPWxM
#CellSignaling
Phospho-specific antibodies support cell signaling research, with coverage of 170+ unique PTMs and lot-to-lot consistency.
Priced 20% lower than the leading competitor with code 20PHOSFEB. ✨
Browse and order here: https://bit.ly/4rAPWxM
#CellSignaling #Technology
Lin Luan, @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. rupress.org/jcb/article/...
#CellSignaling
In @jcb.org, Lin Luan, @jeremybaskin.bsky.social and colleagues @weillinstitute.bsky.social identify the Cullin-3 adaptor SHKBP1 as a non-canonical regulator of p62 phase behavior limiting p62 body formation and affecting Keap1/Nrf2 antioxidant signaling. rupress.org/jcb/article/...
#CellSignaling
multiplex IHC using cell signaling, cell proliferation and cell type biomarkers in human GBM tissue (top left); tumorspheres (bottom left) & mouse brain tumor tissue (right)
Spatial organization of the TME explored using #spatialbiology.
Neoplastic cell signaling and TME complexity are not only dependent on cell intrinsic genetics, but also dependent on cell density & stromal interaction. #cellsignaling #microenvironment #brain #GBM
Signal Transduction and Targeted Therapy welcomes cutting-edge research on stem cells, signaling, and translational medicine.
Submit your work here:
mts-sigtrans.nature.com
#StemCellResearch #CellSignaling
#Drosophila Abi maintains blood cell homeostasis by promoting clathrin-mediated #endocytosis of #Notch, say Hyun Gwan Park, Seungbok Lee and colleagues (Seoul National University): rupress.org/jcb/article/...
#CellSignaling #Development #Cytoskeleton
A crucial step towards understanding tip growth in plants. Ivan Radin @radinbio.bsky.social (University of Minnesota) highlights work from Ryken et al. of the Bezanilla lab (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
#CellSignaling #PlantBiology #PlantCellBiology
This review describes the function of the PI3K pathway, discusses how PIK3CA mutations rewire #CellSignaling, metabolism, & #TumorMicroenvironment, and provides an overview of PIK3CA-targeted therapeutics. @CWRUSOM @cwru
#OpenAccess: doi.org/10.1016/j.ge...
Redox signaling governs stress responses, metabolism, and pathology. New frameworks highlight therapeutic targets across disease contexts.
#RedoxBiology #OxidativeStress #CellSignaling #TherapeuticTargets
www.nature.com/articles/s41...
Loss of ErbB3 redirects Integrin β1 from endosomal recycling to secretion in extracellular vesicles, say Dorival Mendes Rodrigues-Junior, Ana Rosa Sáez-Ibáñez, Ingvar Ferby and colleagues @uu.se: rupress.org/jcb/article/...
#Cancer #Biochemistry #Trafficking #CellSignaling
#Phosphatidylserine exposure and #annexin A5 weaken the #actin cortex in #osteoclast fusion, say Evgenia Leikina, Michael Kozlov, Leonid Chernomordik and colleagues (National Institutes of Health): rupress.org/jcb/article/...
#Membrane #lipid #CellSignaling #Biophysics
Leikina, Kozlov, Chernomordik et al. propose a novel signaling pathway linking together intracellular Ca²⁺ signaling, #phosphatidylserine exposure, #annexin A5 binding and #actin cortex detachment that facilitates #osteoclast fusion. rupress.org/jcb/article/...
#Membrane #lipid #CellSignaling
A new probe illuminates endo-lysosomal Ca²⁺ measurements: a role for vesicular IP3 receptors? Anthony Morgan @ox.ac.uk highlights a new reporter for endo-lysosomal Ca²⁺ developed by Calvo et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
#CellSignaling
Reevaluating the roles of PPARs and nuclear receptors in human #peroxisome biology. New Viewpoint from Fred Mast (@fredmast.bsky.social), Richard Rachubinski, and John Aitchison @seattlechildrens.org: rupress.org/jcb/article/...
#Organelles #Development #Metabolism #CellSignaling #Peroxisomes
This review explores FGF8 expression in humans and mice, its pivotal roles in #CellSignaling, tissue development, and growth regulation, and its links to #DevelopmentalAbnormalities. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Direct measurements of luminal Ca²⁺ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors. New study from Belén Calvo, Sandip Patel, Teresa Alonso @uva-es.bsky.social and colleagues: rupress.org/jcb/article/...
#Technology #Physiology #CellSignaling #Organelles #Lysosomes #Endosomes
RTF1 enhances CLK occupancy and #histone methylation at key #circadian clock pacemaker gene loci, say Xu Liu, Ya Huang, Yong Zhang and colleagues (Soochow University): rupress.org/jcb/article/...
#CellSignaling #Chromatin #epigenetics #Neuroscience #Genetics
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from #Golgi to cell surface, say Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University): rupress.org/jcb/article/...
#Biochemistry #Trafficking #CellSignaling #Wnt
This review explores the #PI3K signaling pathway and its role in reshaping #CellSignaling, #MetabolicProcesses, and the #TumorMicroenvironment, highlighting emerging #therapeutic strategies for #PIK3CA-mutant #Tumors. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
Calvo, Patel, Alonso @uva-es.bsky.social et al. describe a new bioluminescent sensor for measuring luminal Ca²⁺ in a mildly acidic subcompartment of the endo-lysosomal system. rupress.org/jcb/article/...
#CellSignaling #Organelles #Physiology #Technology #Lysosomes #Endosomes
In @jcb.org, Calvo, Patel, Alonso @uva-es.bsky.social et al. describe a new bioluminescent sensor for measuring luminal Ca²⁺ in a mildly acidic subcompartment of the endo-lysosomal system. rupress.org/jcb/article/...
#CellSignaling #Organelles #Physiology #Technology #Lysosomes #Endosomes
