ONLINE NOW!!! Check out this #openaccess #review #article in #CYTOSKELETON. #Mitochondria and the #Actin Cytoskeleton in #Neurodegeneration. onlinelibrary.wiley.com/doi/10.1002/...
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#actin
Posts tagged #actin on Bluesky
In the meantime, the 2nd February issue is live:
link.springer.com/journal/4431...
The cover features work by Sudha Kumari @sudha-kumari.bsky.social and co-workers showing that #actin waves guide #antigen receptors at the #lymphocyte immunological #synapse.
link.springer.com/article/10.1...
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Our March cover (rupress.org/jcb/issue/22...) is an immunofluorescence image of nurse cells in the #Drosophila ovary. #Actin cables (cyan) assembling at the nurse cell cortex co-align with acetylated #microtubules (magenta) as they grow toward the nuclei. See Chou et al. rupress.org/jcb/article/...
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@jcb.org's March cover (rupress.org/jcb/issue/22...) is an immunofluorescence image of nurse cells in the #Drosophila ovary. #Actin cables (cyan) assembling at the nurse cell cortex co-align w/ acetylated #microtubules (magenta) as they grow toward the nuclei. Chou et al. rupress.org/jcb/article/...
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Interesting review from the Notani lab on the different functions and regulatory architectures of transcriptional hubs- including #actin; doi.org/10.1016/j.gd...
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At this high resolution, we also caught something new: Using the new #HAK-Actin #UExM probe, we saw that
#Actin accumulates at the furrow base before compartments fully seal ➡️ they're still open at the bottom.
➡️ The #multicellular epithelium-like stage is shorter than we previously proposed.
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Open Postdoc position in our lab!
#actin #Huntingtin #cryoET #cellbio
If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit.
ista.ac.at/en/job/postd...
Please share and feel free to reach out if there are questions!
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Have you seen this #OPENACCESS #REVIEW #article in #CYTOSKELETON? #Mitochondria and the #Actin Cytoskeleton in Neurodegeneration. Check it out here: onlinelibrary.wiley.com/doi/full/10....
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In @jcb.org, Naidoo, Tam, and Harris @uoftcellsysbiol.bsky.social show that, over the early #Drosophila embryo, a composite of actomyosin and plasma membrane folds conveys cortical tension, and regulation involves PM topography modulation by Arp2/3. rupress.org/jcb/article/...
#Actin #Cytoskeleton
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Naidoo, Tam, and Harris @uoftcellsysbiol.bsky.social show that, over the early #Drosophila embryo, a composite of actomyosin and plasma membrane folds conveys cortical tension, and regulation involves PM topography modulation by Arp2/3. rupress.org/jcb/article/...
#Actin #Cytoskeleton #Development
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Schwarz lab @bostonchildrens.bsky.social identify a mechanism coupling mitochondrial movement to energy demand. When energy levels are low, the energy-sensing kinase AMPK phosphorylates the motor/adaptor protein TRAK1, arresting #mitochondria via the #actin #cytoskeleton. rupress.org/jcb/article/...
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In @jcb.org, the Schwarz lab identify a mechanism coupling mitochondrial movement to energy demand. When energy levels are low, the energy-sensing kinase AMPK phosphorylates the motor/adaptor protein TRAK1, arresting #mitochondria via the #actin #cytoskeleton. rupress.org/jcb/article/...
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#Addendum to 1970 paper, “CYTOPLASMIC FILAMENTS OF AMOEBA PROTEUS: I. The Role of Filaments in Consistency Changes and Movement,” includes eight video sequences originally recorded on 16-mm films. No technology was available at the time to include this data. 🎞️ rupress.org/jcb/article/...
#Actin
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Mechanometabolism of cell adhesion: #Vinculin regulates #bioenergetics via RhoA-ROCK. New study from Emily D. Fabiano, Cynthia A. Reinhart-King (Rice University) and colleagues: rupress.org/jcb/article/...
#Biophysics #Cancer #CellMetabolism #Migration #motility #Actin #Cytoskeleton
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#Addendum to 1970 paper, “CYTOPLASMIC FILAMENTS OF AMOEBA PROTEUS: I. The Role of Filaments in Consistency Changes and Movement,” includes eight video sequences originally recorded on 16-mm films. No technology was available at the time to include this data. 🎞️ rupress.org/jcb/article/...
#Actin
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In @jcb.org, Fabiano, Reinhart-King et al. establish a relationship between #vinculin, cell #bioenergetics, and #migration behavior, and the RhoA/ROCK/myosin II pathway in MDA-MB-231 cells. rupress.org/jcb/article/...
#Actin #Cytoskeleton #Metabolism #Cancer
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Fabiano, Reinhart-King et al. establish a relationship between #vinculin, cell #bioenergetics, and #migration behavior, and the RhoA/ROCK/myosin II pathway in MDA-MB-231 cells. rupress.org/jcb/article/...
#Actin #Cytoskeleton #Metabolism #Cancer
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Regulation of the #formin #INF2 by #actin monomers and calcium-#calmodulin. New study from Miriam Lee, Aiman Jalmukhambetova, T. Emme Burgin, and Henry N. Higgs (Geisel School of Medicine): rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry #CellBiology #ActinDynamics
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High-contrast fluorescence microscopy of a mouse fibroblast cell. The cell glows in neon cyberpunk colors. Cyan actin filaments form the outer shape, magenta microtubules fill the center, and an orange DNA nucleus sits in the middle.
Biology in Cyberpunk mode.
Who said nature needs to stick to earth tones? This NIH3T3 cell has adopted the full vaporwave palette.
Turning a lab workhorse into a neon light show.
🩵 Actin
💜 Tubulin
🧡 DNA
Sometimes science just looks cool.
#SciArt #Vaporwave #Microscopy #actin #Fluorescence
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New preprint:
We identify a dual regulatory role of nuclear FNBP4 in actin dynamics: the C-terminus binds actin, while the N-terminus inhibits the formin FMN1.
Thanks to @Sankar_Maiti @iiserkol, #Actin_Cytoskeleton_Dynamics_Lab
doi.org/10.64898/202...
#actin #biochemistry #nucleus #formin #fnbp4
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New study from Chou, McCartney et al. @cmu.edu demonstrates coregulation of #actin filament assembly/bundling and #microtubule nucleation/organization during #Drosophila #oogenesis, highlighting the coordinated regulation of the #cytoskeleton required during #development. rupress.org/jcb/article/...
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In @jcb.org, Chou, McCartney et al. @cmu.edu demonstrate coregulation of #actin filament assembly/bundling and #microtubule nucleation/organization during #Drosophila #oogenesis, highlighting the coordinated regulation of the #cytoskeleton required during #development. rupress.org/jcb/article/...
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New research from Lee, Higgs et al. shows how #INF2, a key #actin regulator, is activated by calcium-calmodulin and free actin monomers. Actin-binding proteins like profilin and thymosin aren't just helpers - they directly tune INF2 activity. rupress.org/jcb/article/...
#CellBiology #ActinDynamics
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New research @jcb.org from Lee, Higgs et al. shows how #INF2, a key #actin regulator, is activated by calcium-calmodulin and free actin monomers. Actin-binding proteins like profilin and thymosin aren't just helpers - they directly tune INF2 activity. rupress.org/jcb/article/...
#CellBiology
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Hyun Gwan Park et al. show that #Drosophila Abi, a regulator of #actin cytoskeletal dynamics, controls blood cell homeostasis by activating #Notch signaling through #clathrin-mediated receptor #endocytosis. rupress.org/jcb/article/...
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New paper out!
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
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High resolution mapping of the #actin fusion focus reveals #myosin V-dependent formin transport for aster formation. New study from Valentine Thomas (@valthomas.bsky.social), Sophie Martin (@sophiemartinlab.bsky.social) et al: rupress.org/jcb/article/...
#Cytoskeleton #Microbiology #Spombe #Yeast
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#Phosphatidylserine exposure and #annexin A5 weaken the #actin cortex in #osteoclast fusion, say Evgenia Leikina, Michael Kozlov, Leonid Chernomordik and colleagues (National Institutes of Health): rupress.org/jcb/article/...
#Membrane #lipid #CellSignaling #Biophysics
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More goings on in eukaryotic ancestors, this time from @phil-donoghue.bsky.social and friends. The data is coming thick and fast! #actin #nucleus #LECA #asgard #mitochondria #phylogeny
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