This #STTT study provides mechanistic insights into how arginase1 regulates mitochondrial cristae remodeling and #mtDNA release, triggering the cGAS-STING pathway and #PANoptosis during ischemic/hypoxic #VascularDysfunction.

#OpenAccess: doi.org/10.1038/s413...

Arg1 mediates mitochondrial cristae remodeling, #mtDNA release, and activation of the cGAS-STING pathway, resulting in the #PANoptosis of VSMCs during ischemic/hypoxic injury-induced #VascularDysfunction. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Chronic thrombus in veins has greater MMP9 activity than more acute thrombus in arteries, with MMP9 appearing to be derived from macrophages trapped in thrombus. buff.ly/tHkatpL #hemesky #vasculardysfunction