A metabolic alarmin from keratinocytes potentiates systemic humoral immunity - Nature Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

#WeekendRead! #ImmunometabolismPower! #EveryCellIsAnImmuneCell! Ji, Zhang, Lu, Liu &co show @nature.com that infection, irradiation, or lupus #SLE induce a mevalonate intermediates that drives IL6 & CCL20 by #keratinocytes via NFAT to potentate antibody production!

State Property Tax Reform Efforts Continue Amid Local Fiscal Strains In the years following the COVID-19 pandemic, lawmakers have repeatedly pursued measures to cut property taxes—or even eliminate them. But such initiatives often bring new fiscal pressures. They can c...

Important #WeekendRead: The Pew Charitable Trusts recently wrote about the consequences of property tax cuts on local government services. Check it out: www.pew.org/en/research-...

In the background, a pale sun peers over the top of a hill through a hazy red sky. Below it the trees are leafless and there is snow on the ground. Over it is historical fiction novel Tyrant Whelp with the cover featuring the hooded face of a man and a sword protruding from a stone. The text reads In Britannia King Arthur presides over a golden age... But as the sun shines without brightness, the realm is plunged into a wasteland of ice, famine and a war where many of its finest must fall. Yet for Custennin of Dumnonia, greatness beckons. Is he up to the task? Tyrant Whelp https://mybook.to/TyrantWhelp

A kingdom in ruins. A throne up for grabs. And the man who inherits it? Not a hero.
Power corrupts. Loyalty shatters. Who will survive Camelot’s fall?

#Arthurian #HistoricalFiction Tyrant Whelp mybook.to/TyrantWhelp
#eBook #paperback #KindleUnlimited #WeekendRead

Commensal enteric virome regulates intestinal carbohydrate digestion and absorption The enteric microbiome and nutrient sensing within the small intestine play critical roles in maintaining host metabolic homeostasis. Although various…

#WeekendRead! #ViromePower! Lin, Li &co show @cp-cellhostmicrobe.bsky.social that the virome regulates sugar digestion & absorption by intestinal epithelial cells #IECs by favoring production of IL-22 via an antigen presenting cell-#Th17 axis!

Precancerous niche remodelling dictates nascent tumour persistence - Nature A study investigating the emergence of squamous tumours in the upper gastrointestinal tract of the mouse shows that an initial tumour stress response triggers fibroblasts to remodel the underlyin...

#WeekendRead! #SmartTumor! #EveryCellIsAnImmuneCell! Amazing work @nature.com by @mariapalcolea.bsky.social Skrupskelyte, Rojo &co showing the stress response driven by nascent tumors induces a wound healing program in surrounding fibroblasts driving a #PreCancerousNiche that fosters tumorigenesis!

The backdrop of a dawn sky with orange and pink clouds displays historical fiction novel Dawn of the Franks - the story of Basina of Thuringia. The cover features a backdrop of trees silhouetted against an orange sky and the rising sun. In the foreground a blonde man kneels before a medieval couple. A dark-haired man in a red tunic has his arm around a woman with a white mantle and a fur cloak. The text reads 'The might of Rome has waned. And the sun is rising on the Dark Ages'. https://mybook.to/DawnoftheFranks

Bitter betrayal, forbidden romance, and a love story to change the course of history...

#HistoricalFiction Dawn of the Franks - the story of Basina of Thuringia
mybook.to/DawnoftheFra...
#eBook #paperback #KindleUnlimited #WeekendRead #WomensHistoryMonth

HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier Trillions of adhesion-capable bacteria reside in the gut, yet they rarely attach to healthy host tissue. Here, Overstreet et al. reveal that HMGB1 in colonic mucus directly targets bacterial adhesins ...

#WeekendRead! #MisterySolved! Overstreet Messer &co show @cp-cellhostmicrobe.bsky.social that HMGB1 in the gut mucus broadly targets a bacterial virulence factor preventing bacterial mucus invasion & tissue adhesion! #IBD is associated with low HMGB1!

Reciprocal regulation of fibroblast–macrophage equilibrium governs skin integrity - Nature Immunology Turley, Buechler and colleagues show that dermatopontin-expressing fibroblasts provide CSF1 to form a supportive niche for skin-resident macrophages. This interaction is important for skin tissue arch...

#WeekendRead! #EveryCellIsAnImmuneCell! Vollmers Turley &co show @natimmunol.nature.com that lack of CSF1 in skin #fibroblasts decreases macrophage numbers dampening wound repair, and in turn boosts fibroblasts! In human #scleroderma the cellular circuit between fibroblasts & macrophages is altered!

Andrew Mountbatten-Windsor and the strange British phenomenon of the snatched backseat picture Andrew Mountbatten-Windsor is the latest in a long line of famous people photographed in the back of a car.

#WeekendRead

It requires skill, technique, patience - and a little bit of luck.
We've been speaking to snappers about the art of the "one shot" - and also asking showbiz experts why we're all so fascinated by the snatched backseat photo.

www.bbc.com/news/article...

Hanoi's most popular street could kill you Train Street started life as a razor-thin alley with a train rushing through it. Now, it's swarmed with Instagrammable cafes and tourists who can't stay away, despite the risks.

#WeekendRead

Train Street started life as a razor-thin alley with a train rushing through it. Now, it's swarmed with Instagrammable cafes and tourists who can't stay away, despite the risks.

www.bbc.com/travel/artic...

From a terrifying Viking spectre to a fearsome beast stalking Dartmoor's tin miners - enter a world that is Mysteriously Medieval...
mybook.to/Mysteriously...
#eBook #paperback #KindleUnlimited #WeekendRead

A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression An in vivo, noncanonical ferroptosis pathway, critical for tumor supression, is driven by reactive oxygen species-induced phosphatidic acid peroxidation at the ER under the control of the GPX1-OSBPL8 ...

#WeekendRead! #NoTimeToDie! Gu, Kagan, Xia &co show @cp-cell.bsky.social that ROS drive lipid peroxidation at the ER causing membrane rapture & ferroptotic death which is blocked by GPX1 recruitment via OSBPL8 to the ER & oxidized lipid reduction! Knockdown of GPX1/OSBPL8 blocks tumor growth!

#WeekendRead! #InterferonFriendOrFoe? @jeffdowney11.bsky.social @filswirski.bsky.social &co show @cp-immunity.bsky.social that upon severe flu lung infection, IAV is transported to the heart by DCs, where it infects cardiomyocytes to drive IFN-I, causing cardiac dysfunction! doi.org/10.1016/j.im...

A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages Macrophage metabolism is intricately linked to cellular function. Contrasting with Toll-like receptor (TLR) stimulation, cytosolic nucleic acid sensin…

#WeekendRead! #InterferonPower! Dunphy @sancholab.bsky.social &co show @cp-immunity.bsky.social that in #macrophages, STING leads to type I #IFNs & ISG15-dependent ISGlatyion of mitochondrial proteins, increasing efferocytosis & driving epigenetic remodeling thus supporting inflammation resolution!

Why not surprise someone you love with a #Romance #eBook on #ValentinesDay!
Like this #Spooky #HistoricalRomance Call of the Viking Dead
mybook.to/vikingdead
#WeekendRead 📚⚔️👻❤️

#OnThisDay in 858, Scottish king, Kenneth Mac Alpin died.
Follow his rise to power through the eyes of the forgotten woman at his side...

Kenneth's Queen mybook.to/KennethsQueen
#eBook #paperback #KindleUnlimited #WeekendRead #OTD #ValentinesDay 📚⚔️❤️

When you were reading about Botticelli, and the sun decided to add a rainbow to the page. #smalltouchingmoments #weekendread #Botticelli

The rise to power of Cinaed mac Alpin through the eyes of the forgotten woman who must have been at his side...

#Scottish #HistoricalRomance Kenneth's Queen mybook.to/KennethsQueen
#eBook #paperback #KindleUnlimited #WeekendRead #ValentinesDay 📚⚔️❤️

Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation Liu et al. reveal that lactate, an aerobic glycolysis product, promotes NLRP3 inflammasome activation and pyroptosis. NLRP3 is identified as a target of lactylation, and K24 and K565 have potential to...

#WeekendRead! #ImmunometabolismPower! #InflammasomePower! Liu, Yin &co show @cp-cellchembiol that lactate downstream of aerobic glycolysis is used to directly lactylates NLRP3 increasing ASC recruitment and inflammasome activation, which exacerbates lethality in sepsis! www.cell.com/cell-chemica...

A desolate Dartmoor valley is awash with ores the tin miners desperately need.
But what else lurks along the mysterious O Brook?
The Stannary Dragon is only #99cents or #99p
mybook.to/stannarydragon
#HistFic #HistoricalFantasy #HistoricalRomance #KindleCountdown #WeekendRead 📚🐉

Need a #weekendread? Try RIPPLES THROUGH TIME – a #dualtime #romance featuring #Vikings, #buriedtreasure and #ghosts from the past!

A #bargain at only 99p right now!

geni.us/ripplestime

You stop him from jumping and he thinks you're his angel. Then you become his obsession.
A #PsychologicalThriller for your #WeekendRead
#BookSky📚💙
➡️ mybook.to/SOABeb ⬅️

Two Visions for Navigating AI’s Adolescence: Altman and Amodei on the Rite of Passage Ahead Two Visions for Navigating AI's Adolescence: Altman and Amodei on the Rite of Passage Ahead In the span of a single week in early 2026, we received two remarkably different articulations of where artificial intelligence is taking us, and what dangers lie ahead. Sam Altman's town hall with AI builders offered a pragmatic, iterative vision of abundance tempered by marketplace realities (read our earlier analysis here). Dario Amodei's essay "The Adolescence of Technology" presents a systematic taxonomy of existential risks that demand a coordinated societal response. Both leaders believe we're approaching transformative AI capabilities within 1-2 years.

AI is in its messy adolescence. 👀 My latest weekend read explores two very different paths from Altman (OpenAI) and Amodei (Anthropic) and what they mean for our future with AI. How do you see AI evolving? I also offer some thoughts. 📚🤖 #AI #AIFuture #WeekendRead #SeriousInsights

Jewish Book Council's February Reads New York is layered with snow, and the temperature shows no sign of rising above freezing. Luckily, the Jewish Book Council team has plenty of great books to curl up with!

What's the Jewish Book Council team reading this month? Find out below and share your #WeekendRead with us! bit.ly/4r09TOD

The backdrop of a starry sky features the silhouette of a tree and a woman holding a candle. She is in a long dress, with blood-like stains surrounding her. Over the tree is the Mysteriously Medieval logo. Beside the woman is spooky historical fiction novel Call of the Viking Dead. The cover features a hand emerging from the ground with runes tattooed on the wrist and gripping an axe. The backdrop is of gravestones and crows. Behind the title is the shadowy image of a skull. The text reads Fiske, the evil but slain Viking jarl, stalks 9th-century Devon. Who must answer the Call of the Viking Dead? https://mybook.to/vikingdead

AD 851: Ceorl, Alderman of Devon, defeats a Viking attack.
Little does he realise that the worst is yet to come...

#Spooky #HistoricalFiction Call of the Viking Dead mybook.to/vikingdead
#WeekendRead #GhostStory #eBook #paperback #KindleUnlimited ⚔️👻📚

Mitochondrial transfer from glia to neurons protects against peripheral neuropathy - Nature Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuro...

#WeekendRead! #SharingIsCaring! Ji, Xu &co show @nature.com that glia transfers mitochondria to sensory neurons via tunneling nanotubes, which are altered in #diabetes causing neuropathy!
doi.org/10.1038/s415...

B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells B cells transiently increase interleukin (IL)-2 receptor expression upon activation. Gauthier et al. examine the B cell-intrinsic role of IL-2 and define an IL-2-MAF axis that promotes the differentia...

#WeekendRead! #FirstLove #IL2power #IL10power #InterferonPower! Delaloy, Gauthier &co show @cp-immunity.bsky.social that IL2 favors a regulatory program in B cells that, together IFNg, induces IL10 production, protecting against neuroinflammation! Exciting paper 🤗! www.cell.com/immunity/ful...

#WeekendRead Jim Butcher's long-awaited 18th installment in the #DresdenFiles series.
buff.ly/VawdboP

A #bargain #travel #thriller on offer for your #WeekendRead...
#BookSky📚💙

My #weekendread is quite the tome. It's a defense of Enlightenment ideals that's deep and approachable. Pinker supports his arguments with statistical evidence and insights from great philosophers, tackling our tendency toward unwarranted pessimism. Highly recommended.
amzn.to/4jwwIXk