Opportunities and challenges of targeting cGAS–STING in cancer - Nature Reviews Cancer In this Review, Lu et al. discuss the dual role of the cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS)–stimulator of interferon genes (STING) pathway in cancer, emphasizing its involvement in both tumour suppression and promotion. They highlight the diverse sources of pathway activation and suggest that this functional duality may underlie the limited clinical success of cGAS–STING targeting in cancer therapy.

Weekend reading 🚨
A comprehensive #Review on the dual role of the #cGAS–#STING pathway in cancer, emphasizing its involvement in both tumour suppression and promotion, which might underlie the limited clinical success of cGAS–STING targeting in cancer therapy.
📖👇

Activation of the cGAS–STING pathway drives #RetinalInflammation in #endotoxin-induced #uveitis, while genetic deletion of #cGAS reduces #vitreous inflammation, vascular leakage, and #microglial activation. @fudan-university.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...

A molecular mechanism in Naked Mole Rats enables DNA repair and delays aging [via Science.org] 🧪⚗️⚕️🐀🧬🏗️

"Unlike human cGAS, [...], the naked mole rat enzyme has four amino acid changes that [] enhance DNA repair,"

www.science.org/doi/10.1126/...

#aging #delay #DNA #repair #cGAS #naked #mole #rat

This week #JournalClub @labsoap.bsky.social #DNArepair #cGAS #STING @science.org #molerat 🐀 www.science.org/doi/10.1126/...

A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...

#LiveForever! Chen, Mao &co show @science.org that not all #cGAS are equals & that naked mole-rats one bears a 4 amino acid mutation which enhances DNA repair & when transferred in aged mice dampens frailty, hair graying, inflammatory & senescence markers! www.science.org/doi/10.1126/...

🏆 Nobel Prize 2025 Coming Soon | This Year’s Most Anticipated Breakthroughs
🛡️ Innate immunity = first defense & cancer fighter.
🧬 cGAS-STING: #cGAS senses foreign DNA → STING → IRF-3 & NF-κB → type I interferons & #cytokines → stronger #tumor #immunity. 🔗 https://ow.ly/foGZ50X2FLx
#NobelPrize

Daily Hack Notices: #tdktech, #molodspitz, #fluxergy, #std-iron, #cartonajesbernabeu, #nubox, #sumasaas, #gazomet, #cgas, #noblecorp, #epiafs, #chamonix-guides, #rggroup, #rgelectric, #biw-burger, #ip...

Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...

This week #JournalClub @LabSoap @cellpress.bsky.social #CGAS #DNAamplification #virus www.cell.com/cell/abstrac...

Excited to share our latest work out in @pnas.org! We show that the #SARSCoV2 nucleocapsid protein directly prevents DNA recognition of the immune sensor #cGAS by competing for DNA, which may delay early innate immune responses during infection. www.pnas.org/doi/epub/10.... #innateimmunity

Inhibition of Cyclic GMP-AMP Synthase Ameliorates Cardiac Dysfunction in Rats After Cardiac Arrest Cyclic GMP-AMP synthase, cardiac arrest, cardiac dysfunction, return of spontaneous circulatio

#cGAS upregulation after #CardiacArrest triggers mitochondrial damage, #oxidativestress & #apoptosis. Pharmacologic (RU.521) or genetic inhibition of cGAS improved heart function, highlighting cGAS as a novel therapeutic target.

Read more: cvia-journal.org/inhibition-c...

#HeartFailure #Immunology

Together with the Roers Lab from @uniheidelberg.bsky.social and @bms-us.bsky.social we propose that controlled low level systemic activation of #cGAS by endogenous nucleic acids is a safe and effective way to boost #cancer #immunotherapy.

aacrjournals.org/cancerres/ar...

Gabo Birkus from @iocbprague.bsky.social is opening the last presentation stream at #BioVaria2025

#cGAS #CD3 #BioVaria #autoimmune

Canadian Game Awards 2025 Recap - Indie Game Reviewer - The Best Indie Games The 2025 Canadian Game Awards covered by David Carcasole, who braved a winter snowstorm to attend the Toronto event at TIFF Lightbox

🎮 Canadian Game Awards 2025 Recap >>>
indiegamereviewer.com/canadian-gam...

#indiegames #indiegamedev #videogames #cgas

Styrax will be part of the Eh! Game Expo at the 2025 Canadian Game Awards on February 15th in Toronto!

Play BUTTON MAN alongside 14 other great Canadian games at the TIFF Lightbox – and then attend the CGAs!

More info here: cgameawards.com/ehgameexpo

#CanadianGameAwards #CGAs #indiedev #ButtonMan

Stimulating #labmeeting today by #postdoc Salwa Soussi, PhD on #aging and how it is modulated by novel #RNAdrug #TY1. Strong evidence for central role of #cGAS #STING in cardiac #senescence. Animated discussion followed!

Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...

Showcasing this exciting paper from our good friends Fachinetti lab @institutcurie.bsky.social. #Centromere inactivation triggers #senescence: mis-segregated chromosomes deform the nuclear envelope and activate TORC2-ATR. We helped with #cGAS and some key suggestions.
doi.org/10.1038/s415...

Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells Both cytosolic DNA species and innate immune STING signaling are required for stressed cells to activate phagocytes.

This week in #Science #Immunology: Glen Barber & colleagues report that #cGas – #STING signaling in phagocytosed DNA-damaged cells facilitates #APC activation via formation of STING-inducible endosomal vesicles (SIEVES) containing immune-activating proteins and cytosolic DNA!

Tell your friend that the drones can be spotted On the Lower Cape, over Nantucket Sound, in Harwich, Harwichport, Chatham. Also spotted hovering over Upper Cape: Barnstable & Osterville, near #Otis / #CGAS #CapeCod. Also on Outer Cape: Wamsutta Road, Eastham.

Good luck!

#Drones #UAP #UFOsky #UFO

#Drones #CapeCod #Boston #Massachusetts #Northeast #Connecticut #NewYork #NewJersey #Jersey #UFO #UFOsky #EADS #CGAS #Otis #NORAD #Pentagon #DOD

Discovery of cGAS as a DNA-Sensing Enzyme That Triggers Inflammation: 2024 Albert Lasker Basic Medical Research Award In this Viewpoint, 2024 Albert Lasker Basic Medical Research Award winner Zhijian J. Chen describes his discovery of cyclic guanosine

#MedSky🧪#ImmunoSky Zhijian “James” Chen, winner of the 2024 Basic Research #LaskerAward on the approaches he and his lab implemented in the discovery of #cGAS, a DNA-sensing enzyme that triggers inflammation

jamanetwork.com/journals/jam...

Evolutionary immunology to explore original antiviral strategies | Philosophical Transactions of the Royal Society B: Biological Sciences Over the past 25 years, the field of evolutionary developmental biology (evo–devo) has used genomics and genetics to gain insight on the developmental mechanisms underlying the evolution of morphologi...

Next is a review and thought piece by Imler, Cai, Meignin, and Martins. Their work on #cGAS - #STING signalling the last few years has been 🔥

Their work highlights just how diverse #antiviral #immunity is across species. Some neat ideas in this piece for #immune researchers in general. 🧵 3/n