👋Our February issue is out!
Cover: spatial #transcriptomics
👉Review: telomeric #chromatin
🔬 #mitochondria #mitophagy #senescence #p53 #epigenetics #glioblastoma #IDR #immunotherapy #cGASSTING #apoptosis #lysosomes & more!
www.nature.com/ncb/volumes/...
⬇️ review unpacks how radiotherapy can trigger abscopal immunity: turning local DNA damage into systemic tumor control. Link: buff.ly/4lXAUWK
#Radiotherapy #AbscopalEffect #Immunotherapy #Oncology #cGASSTING #IO #CancerResearch
This review highlights how endo/exonucleases regulate #DNADamage repair, #genome stability, and #cGASSTING signaling, with controlled activity preventing #autoimmunity while excessive cleavage enhances #CancerImmunotherapy. #AutoimmuneDiseases
#OpenAccess: doi.org/10.1016/j.ge...
🔦 Have you seen our latest Commentary?
TREX1, a predator for treating MSI-H tumors?
🔓 buff.ly/MAOG3pB
#cGASSTING #ImmuneEvasion #CancerResearch
Four. Major. Awards. In One Year. 🤯
Dr. James Chen out collecting Lasker Awards & other prestigious prizes like Pokemon. His cGAS-STING discovery solved a 100-year-old immunity mystery!
Catch his keynote Nov 4th at Cytokines 2025!
buff.ly/nT5nD6E
#LaskerAward #cGASSTING #AwardSweep #InnateImmunity
Online now - the Forum "The interplay of the cGAS–STING pathway with the lysosome" from Yinfeng Xu and Wei Wan.
#InnateImmunity #Lysosome #cGASSTING
Read it here: authors.elsevier.com/a/1lpuN_M0e4...
as in @LauraENewman1 et al. show that, upon #mtDNA #ReplicationStress, enlarged nucleoids are trafficked to #endosomes. Endosomal rupture releases mtDNA in the cytoplasm, activating #cGASSTING.
@manorlaboratory, @salkinstitute
👉🏾
rdcu.be/dyV6K
