See how your Spikeling neuron firing action potentials would look like in a extracellular ephys setup live. Features :
- Spatial integration, see how the electrode placement relative to the neuron impacts the extracellular field recordings, determining for spike sorting. #Ephys
WORD 2026 - This year, we presented a scientific poster on CorePlate™ recordings of hippocampal organoids and their responses to various neuroactive compounds. A huge thank‑you to everyone who visited our booth, discussed their work, and shared new ideas!
#WORD2026 #BrainOrganoids #HDMEA #Ephys
🚨 We’re hiring! The St-Pierre Lab at Baylor College of Medicine has exciting opportunities:
🔬 Postdoctoral position
👩🔬 Staff position
Work on cutting-edge electrophysiology and optical tools to advance neuroscience!
See: shorturl.at/uim4d
#Neuroscience #Ephys #PostdocJobs
My postdoc (mainly) and I have just completed a 2-month long behavioral experiment (60+ mice, 3 time-points); collected our first #ephys data for a collaborative project (on a NEW rig 👀👀); and finished drafting the lab's first big grant (to-be-submitted soon🤞)
We.need.holidays.
Happy to share our new preprint
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.
⚡We are finally electrocuting DRG neurons in the @alleslab.bsky.social since moving to @cincychildrens.bsky.social! #PainResearch #ephys #NeuroSkyence
Planning to record LTP or LTD in acute brain slices with whole-cell patch clamp? Give my latest article on Scientifica's NeuroWire a look! www.scientifica.uk.com/learning-zon... #plasticity #patchclamp #electrophysiology #ephys 🔬🪄⚡️
Finally, the full version of our paper on the distribution of functions within monkey VLPF is out! For anyone interested, I'll briefly explain the main results in this thread (1/5) @plosbiology.org #prefrontal #neuroscience #ephys #dataanalysis
That unforgettable moment I learned how to patch neurons! 🧠✨ #ephys #MyMBLMoment @neurobiombl.bsky.social
I can never get bored of recording action potentials from my iPSC sympathetic neurons and the RMP was -70mV 😍 #patchclamp #ephys
We integrate anatomy, #ephys, ex/in vivo NPY dynamics, chemogenetic & pharmacological interventions..so a little something for everyone.
We hope you ll read, learn & enjoy as much as we did while working on this project!
We hope you read and enjoy
Even though it looks like some kind of Eldritch creature, my army of reference electrodes will soon be ready to perform brain recordings. 🐙🧠 #ephys
Congrats Team! Carole and Antoine (@antoinecourbi.bsky.social) got their first #Neuropixels recording in our brand new virtual reality setup for mice! This is a big step for our lab. Excited to see what comes next!! #neuroscience #ephys
@sdavidson.bsky.social @karapedsgastrodoc.bsky.social Such an adventure! 🔥🧫🧬🔬⚗️🥼🧪🧑🔬👩🔬👨🔬 #ephys #pain #Labteam #paineurobio
@NYUPainResearchCenter a #HUGE shout out and warm #WELCOME to @sdavidson.bsky.social PRC is extremely excited for this new addition to our Lab! 👏🥳 #anamanu #stevedavidsonlab #newbies #labfam #paineurobio #ephys
Get a hands-on glimpse into the various software tools @ebrains.bsky.social has to offer, Europe's emerging RI for brain research. Choose from over 16 software tutorials -- I will also be there with a tutorial on #ephys data analysis using Elephant and data handling with Neo. See you there!
A microscope image of a biocytin-filled neuron floating about in a brain slice. The background is dark and the cell body, and few proximal dendrites are seen in yellow.
I missed the chance to post last Friday, so here is my #MicroscopeMonday contribution of a floating neuron from my #ephys slices. (indeed this is from the LC, no, not a NE cell)
🧵5/n
Leveraging the ion recognition power of small molecule chemistry should also allow rather higher ion specificity of photocurrents than #optogenetics approaches, as well as the higher currents overall.
#ephys #chembio
Indeed, cKO of interneuronal α1ARs had no effect on either NE- or stress-evoked pain hypersensitivity.
To establish an interaction between SDH astrocytes & INs, they followed up with some beautiful slice #ephys, in combination with smart CRISPR-Cas editing, pharmacology and chemogenetics. 7/
Hey #ephys folks, what is the best way to pharmacologically isolate kainate receptors from AMPARs for patching? Any insights help, looking for current best practice!
Using slice #ephys and #CRACM, the authors first showed functional connectivity between VTA and the LC, specifically a monosynaptic excitatory input onto noradrenergic neurons.
In vivo, photostimulation of VTA->LC glutamatergic terminals induced real-time & conditioned avoidance. 3/
On the rig today, after a long break. Spent half the day cleaning electrodes, changing tubing, fixing the suction, chasing after tie wraps & sweet-talking my pump. Got couple of cells in the end, just trash-data for protocol optimization..
IT WAS GLORIOUS
#ephys #patchclamp
Tune in today to learn about #DBS-EvokedPotentials ⚡️🧠 and how we can use them to #map the therapeutic target in #Parkinson‘s disease and #Depression. Super excited that I am able to speak about my favourite #ephys topic together with @allisonwatersphd.bsky.social ! 🙌🏻📉📈📉📈📉📈📉
2P or not 2P? That is no longer the question! The lab is excited to expand beyond #ephys with two-photon calcium imaging. First images of neuronal populations in the mouse frontal cortex acquired today!
#neuroscience #imaging #flurorescencefriday
In vivo #ephys community, any tips on separating putative interneurones from pyramid cells spikes? 🤔
The spike sorting litterature seems more qualitative than quantitative and I lack keys to fully get how to sort my data. I think SpikeInterface gives me all the needed data to perform it correctly 😀
Preprint is up! www.biorxiv.org/content/10.1... Trevor Docter + Ben Sorum found cannabinoids inhibit mechanosensitive K+ channels, including TRAAK mutants that cause epilepsy and FHEIG in humans. #ephys and #cryoem shows CBD competes with lipids to bind inside the channel cavity and block the pore.
