Introducing RMzyme, a #Multiomics platform mapping RNA-modifying enzymes across 63 human tissues to elucidate how #Epitranscriptomic regulation and PTM networks drive cellular function and disease #Pathogenesis.

#STTT #OpenAccess: doi.org/10.1038/s413...

New preprint benchmarks #Nanopore direct RNA sequencing for quantitative m6A mapping, revealing best practice filters and cell type specific #epitranscriptomic differences in fibroblasts and neurons. #RNAseq
📄 https://doi.org/10.1101/2025.11.02.686099 
👤 EVBC member: Daniel Depledge

This review examines the #Epitranscriptomic regulation of intestinal #Macrophages, emphasizing their role in sustaining gut #Immune #Homeostasis and providing a framework for understanding #RNA-mediated #ImmuneRegulation. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Now we need the #epitranscriptomic version 🤷‍♀️🤪

Epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures Mammalian ribosomal RNA (rRNA) molecules are highly abundant RNAs, decorated with over 220 rRNA modifications. Previous works have shown that some rRN…

And the findings that #epitranscriptomic fingerprinting accurately classifies clinical samples into normal & tumor groups from only 250 reads per sample, demonstrating the potential of rRNA modifications as diagnostic biomarkers.
www.sciencedirect.com/science/arti...