Espectròmetre de masses MALDI-TOF/TOF RapifleX Imaging de Bruker Daltonics disponible a la Unitat d’Anàlisi Biomolecular dels entres Científics i Tecnològics de la Universitat de Barcelona.

🆕 Nou espectròmetre de masses a la Unitat d’Anàlisi Biomolecular dels #CCiTUB @ub.edu!

L'equip @brukercorporation.bsky.social està dissenyat per a tècniques de #MALDI #Imaging i permet l’anàlisi de molècules petites, pèptids, proteïnes, glúcids i altres biomolècules.

ℹ️https://tuit.cat/sbtF2

Thanks to speakers &guests who attended MALDI Tech Users Day @kingscollegelondon.bsky.social. Feedback was super! It's great to show how Shimadzu operate differently
#collaboration #madeintheUK #MALDI #technology #massspec🧪
@northernanalyst.bsky.social @aniacooper.bsky.social @jen-field.bsky.social

MALDI Technology Users Day

MALDI Technology Users Day

MALDI Technology Users Day

MALDI Technology Users Day

Last 3 talks of #MALDI #Technology Day:
‘Tips & Tricks: EasyCare’, A Baumeister & O Slingsby-Wolfe, Shimadzu
‘MALDI-Made in UK 🇬🇧: Behind Scenes at Kratos’, K Worrall, Kratos Analytical
‘Intro to Imaging’, A Baumeister & O Slingsby-Wolfe of Shimadzu
@northernanalyst.bsky.social
#UKScience🧪 #massspec

Our MALDI Technology Users Day has now kicked off - 1st talks prompting great debate:
Core Principles & Techniques from Ollie Slingsby-Wolfe, App Stories From All Over Europe from Andreas Baumeister & Entering the Matrix from Oscar Ayrton
@northernanalyst.bsky.social
#MALDI #technology #Manchester

Shimadzu MALDI Day

Shimadzu MALDI Day

All set up & ready to go at @kingscollegelondon.bsky.social for our MALDI Technology Day tomorrow!
With Ollie Slingsby-Wolfe Oscar Ayrton Emma Poole @becky-piper.bsky.social @northernanalyst.bsky.social G Ilyashenko Andreas Baumeister Keith Worrall Howbeer Ali & Syed Mustafa

#MALDI #Manchester 🧪

Howbeer Muhamad Ali

🌟 Join us on Jan 22, at @kingscollegelondon.bsky.social for a session on #MALDI technology & applications across industries!
🧪 Hear Howbeer Muhamad Ali from University of Liverpool share Bacterial Metabolism insights.
👉 More info cutt.ly/HttTEl8V

#chromatography #massspec #UKScience #AcademicSky 🎓

Howbeer Muhamad Ali

🌟 Join us on Jan 22, at @kingscollegelondon.bsky.social for a session on #MALDI technology & applications across industries!
🧪 Hear Howbeer Muhamad Ali from @liverpooluni.bsky.social share Bacterial Metabolism insights.
👉 More info cutt.ly/HttTEl8V

#chromatography #massspec #UKScience #AcademicSky

Just one week to go until the #Pharmig Conference in Nottingham! 🧪 #Micronclean and #AssuredMicro will be there, highlighting our cleanroom expertise and advanced #MALDI-TOF technology for the pharmaceutical and healthcare sectors.

#Cleanroom #CleanroomCleaning #Pharmaceutical

This week, our amazing team have been meeting people at British Mass Spectrometry Society's annual meeting in Edinburgh - and everyone was a winner with the Drop Disk Game!
#MALDI #GCMS #LCMS #massspectrometry #massspec 🧪
@bmss-official.bsky.social

👉 ur-bia.angers-nantes.hub.inrae.fr

#MRI #MALDI #Raman #AFM #ImageRegistration #ImageProcessing #BioImageAnalysis

Multi-Modal Spatial Metabolomics with Mid-Infrared Microscope Guided Mass Spectrometry Imaging.
J. Vis. Exp. (221), e68709 (2025)
doi.org/10.3791/68709
#methods #infrared #maldi #tissue

Balstīt savu ticību uz nepareiza pamata Noklausies šo e-publikāciju Ikvienai žēlastību meklējošai dvēselei ir būtiski vairīties no visizplatītākajiem un kaitīgākajiem maldiem, kas mēdz pavadīt mācību par dievbērnību, tas ir, cilvēki vispirm...

Balstīt savu ticību uz nepareiza pamata www.ebaznica.lv/balstit-savu... #maldi #dievbērnība

“Ho mal di testa”: e muore dopo le dimissioni dall’ospedale, l’Asl avvia indagini I vertici sanitari mettono sotto la lente quanto accaduto lo scorso 12 maggio dopo che un paziente era stato visto dai medici dell’ospedale della Fratta a Cortona. L’uomo era già stato ricoverato in aprile per un trauma cranico

➡️ Leggi l'articolo: #maldi

Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum Nature Communications - Deep learning enhanced chemical imaging delineated polymorphic Aβ plaques in situ. Cored plaques were associated with increased Aβ1-40 and 3pE-42 deposition. A...

Happy to share our latest work published today in @natcomms.nature.com
We leverage #ai enhanced microscopy guided #maldi #msimaging to delineate #amyloid plaque polymorphism in #Alzheimers Fantastic collaboration with @michaelschoell.bsky.social and @tammarynlashley.bsky.social

rdcu.be/ejcHj

7/ Compared to spray-coating, LTE shows:
✔️ Improved ionization
✔️ Reduced analyte diffusion
✔️ Better image sharpness
✔️ Cleaner baseline

8/ LTE pushes the boundaries of matrix deposition for MALDI-MSI. Better control, better data, better images. #MALDI #MassSpec #MSI #Metabolomics #Lipidomics

Candida diagnostics in endovascular infections. Is @brukercorporation.bsky.social #MALDI better for Candida pararugosa? #ESCMID2025

MSIght: A Modular Platform for Improved Confidence in Global, Untargeted Mass Spectrometry Imaging Annotation Mass spectrometry imaging (MSI) has gained popularity in clinical analyses due to its high sensitivity, specificity, and throughput. However, global profiling experiments are often still restricted to LC-MS/MS analyses that lack spatial localization due to low-throughput methods for on-tissue peptide identification and confirmation. Additionally, the integration of parallel LC-MS/MS peptide confirmation, as well as histological stains for accurate mapping of identifications, presents a large bottleneck for data analysis, limiting throughput for untargeted profiling experiments. Here, we present a novel platform, termed MSIght, which automates the integration of these multiple modalities into an accessible and modular platform. Histological stains of tissue sections are coregistered to their respective MSI data sets to improve spatial localization and resolution of identified peptides. MS/MS peptide identifications via untargeted LC-MS/MS are used to confirm putative MSI identifications, thus generating MS images with greater confidence in a high-throughput, global manner. This platform has the potential to enable large-scale clinical cohorts to utilize MSI in the future for global proteomic profiling that uncovers novel biomarkers in a spatially resolved manner, thus widely expanding the utility of MSI in clinical discovery.

MSIght: A Modular Platform for Improved Confidence in Global, Untargeted Mass Spectrometry Imaging Annotation

#MALDI #MSI #proteomics #metabolomics #multiomics

doi.org/10.1021/acs....

Unleashing the Power of Automation in Bacterial Identification <p>In the world of microbiology, rapid and accurate bacterial identification is essential.</p> <p>Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has emerged as a powerful tool for this purpose, providing a rapid and reliable method for identifying bacteria based on their unique protein fingerprints. However, the sample preparation process for MALDI-TOF MS can be time-consuming and prone to human error, hindering efficiency and potentially impacting the accuracy of results. This potential bottleneck can be addressed by automating parts of the sample preparation process.</p> <p>This application note, based on the master thesis of <a href="https://www.linkedin.com/in/jeremy-provoost-35b6582bb/" target="_blank">Jeremy Provoost</a>, explores how the <a href="t3://page?uid=225" target="_blank">PAL System</a> can automate key sample preparation steps for MALDI-TOF MS, streamlining workflows and enhancing the reliability of bacterial identification. &nbsp;</p> <p><strong>Two Automated Methods for Enhanced Efficiency:</strong></p> <p>The application note focuses on two distinct automated methods: the Formic Acid (FA) method and the Beads method. &nbsp;</p> <ul> <li><strong>FA Method:</strong> This method utilizes chemical lysis with formic acid to extract proteins from bacterial cells. It requires minimal sample material and is particularly effective for identifying Listeria species. &nbsp;</li> <li><strong>Beads Method:</strong> This method employs mechanical lysis using glass beads to disrupt bacterial cells and release proteins. It may be more universally applicable due to its ability to handle bacteria with tougher cell walls. &nbsp;</li> </ul> <p><strong>Benefits of Automation:</strong></p> <p>By automating these methods, the PAL System offers significant advantages:</p> <ul> <li><strong>Reduced processing time and labor costs</strong> &nbsp;</li> <li><strong>Minimized human error and improved consistency</strong> &nbsp;</li> <li><strong>Enhanced accuracy and specificity of results</strong></li> </ul> <p><strong>Explore the App Note below to see which bacteria were identified with the respective automated workflows.</strong></p>

🦠 MALDI prep automated + on plate spotting! Automated FA & Beads methods save time and boost accuracy. Jeremy Provoost's thesis w/ Stefan Gaugler. More: www.palsystem.com/en/newsroom/news/bacteri... #Microbiology #MALDI

Newsroom spotlights: Bacterial ID & Blood Analysis! Plus, Prof. Mayer interview next week! Check out our newsroom for the details. #Automation #MALDI #GCMS #TeamMassSpec  https://www.palsystem.com/en/newsroom/

Kā var atšķirt viltus brīnumus no īstiem brīnumiem? Viltus brīnumi var būt tik veikli nomaskēti un notikt tik lielā ārējā dievbijībā, ka pamanīt tajos viltu var būt grūti.

Kā var atšķirt viltus brīnumus no īstiem brīnumiem? www.ebaznica.lv/ka-var-atski... #pievilšana #maldi

Vai ir arī viltus brīnumi? Ir arī viltus brīnumi un it sevišķi daudz to būs pirms pasaules gala.

Vai ir arī viltus brīnumi? www.ebaznica.lv/vai-ir-ari-v... #kārdinātājs #maldi

MALDI is such a great technique.
A few years ago, I was profilling historic sinew to identify the species of origin using ZooMS methodologies.
This kind of work can be done easily on the MALDI-8020 from Shimadzu. I know this because I did it with samples from the British Museum.
#MALDI #Shimadzu

Some of my favorite mass spec imaging data of the year 😍 Fibrotic #liver and shining #lipids.
#liversky #MassSpec #MALDI #metabolomics

#metabolomics #MALDI #lipidtime
We will highlight the results of our field of 2024, with Giovanni D'Angelo and our PhDs! Huge thanks to our team: Luca Fusar Bassini, Xinyi Huang, Nika Gorsek, Alessandro Valente, Agostina Crotta Asis, Laura Capolupo, Hannah Schede, Jean Maillat, Jiayian Lin. 2/4

What experiment would you run if you had a #maldi #timsTOF? I especially am curious to hear from the #metabolomics community #secondarymetabolism #science #PhDSky 🧪

Interested in #singlecell and #spatial #metabolomics? Then book your calendar for December 10th! – Our online, free event will summarize major achievements of the field in 2024. #metabolism #omics #MALDI #EPFL With Giovanni D'Angelo and our #PhD students we prepared for you a fantastic lineup. 🧵 1/5