🔬 Understanding the Cell Cycle in Radiation Therapy
📚 Continuous learning strengthens clinical excellence.
#RadiationTherapy #CellCycle #RadiationTherapists #CancerTreatment #Radiobiology #MedicalPhysics #OncologyEducation #RTT #RadiationOncology #GART #GlobalRadiationTherapists
Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma
In this study, the researchers spotlight the #Antitumor potential of variant 7 among synthesized pyrrolidone compounds in #DLBCL cell lines, which induces #DNAdamage, #Inflammatory responses, #CellCycle arrest, & #Apoptosis. #medsky
To read: doi.org/10.1007/s115...
Cdc5-mediated Ulp2 phosphorylation controls the timing of polySUMOylation during the cell cycle. New study from Emily Gutierrez-Morton, Yanchang Wang and colleagues (Florida State University): rupress.org/jcb/article/...
#Genetics #CellCycle #CellDivision
In @jcb.org, Emily Gutierrez-Morton, Yanchang Wang and colleagues show that in yeast, polo-like kinase Cdc5 promotes the phosphorylation of SUMO protease Ulp2, reducing its affinity for SUMO chains and thereby facilitating polySUMOylation. rupress.org/jcb/article/...
#Genetics #CellCycle
Emily Gutierrez-Morton, Yanchang Wang and colleagues show that in yeast, polo-like kinase Cdc5 promotes the phosphorylation of SUMO protease Ulp2, reducing its affinity for SUMO chains and thereby facilitating polySUMOylation. rupress.org/jcb/article/...
#Genetics #CellCycle #CellDivision
📖 Lee el artículo completo → doi.org/10.1016/j.is...
🧾 Gálvez-Merchán et al., 2026 – iScience
#iScience #CellCycle #BiologíaCelular #Investigación #Ciencia #Research
I have multiple positions available to join my lab from this summer: #postdoc, #student and #technician. Adverts to follow but see www.saurinlab.com for further details. #senescence, #mitosis, #cellcycle, #phosphorylation are the key areas. Email me if interested.
Early resolution of sister chromatids during #Celegans #meiosis. New study from Antonia Hamrick and Ofer Rog @theroglab.bsky.social @uofubiology.bsky.social: rupress.org/jcb/article/...
#Chromatin #epigenetics #Genetics #CellCycle #CellDivision
This review shows how dysregulated #SUMOylation drives #glioblastoma aggressiveness via #cellcycle, AKT, #microRNAs & #DNARepair, highlighting Ubc9/SAE1 as targets and SUMO inhibitors as promising strategies against proliferation & resistance.
#OpenAccess: doi.org/10.1016/j.ge...
In @jcb.org, Antonia Hamrick and Ofer Rog @theroglab.bsky.social define the organization of the sister chromatids during #meiosis in #Celegans. Sisters are found to occupy distinct volumes when meiotic exchanges form. rupress.org/jcb/article/...
#Chromatin #epigenetics #Genetics #CellCycle
Antonia Hamrick and Ofer Rog @theroglab.bsky.social define the organization of the sister chromatids during #meiosis in #Celegans. Sisters are found to occupy distinct volumes when meiotic exchanges form. rupress.org/jcb/article/...
#Chromatin #epigenetics #Genetics #CellCycle #CellDivision
MAFB and #CEBPA promote #urothelial growth, and their reduced expression in #hypospadias reveals a pathogenic mechanism whereby MAFB knockdown suppresses CEBPA, inhibits #Wntβcatenin signaling, arrests the #cellcycle, and induces #apoptosis.
#OpenAccess: doi.org/10.1016/j.ge...
CKS-1 and the choreography of meiotic chromosome segregation. Shabnam Moghareh, David Bojorquez, and Pablo Lara-Gonzalez @ucirvine.bsky.social discuss work from Yang et al. (rupress.org/jcb/article/...) In Spotlight: rupress.org/jcb/article/...
#CellCycle #CellDivision #Development #Meiosis
Anaphase onset requires CKS-1 mediated destruction of securin in #meiosis I and #cyclin B1 in meiosis II, say Jie Yang, Eisuke Sumiyoshi, and Bruce Bowerman @uoregon.bsky.social: rupress.org/jcb/article/...
#CellCycle #CellDivision #Genetics #Celegans
#Condensin II collaborates with #cohesin to establish and maintain #interphase #chromosome territories, say Takao Ono, Tatsuya Hirano (Riken) and colleagues: rupress.org/jcb/article/...
#CellCycle #Biochemistry #Chromatin
In @jcb.org, Takao Ono, Tatsuya Hirano et al. show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. rupress.org/jcb/article/...
#CellCycle #Chromatin
Takao Ono, Tatsuya Hirano et al. show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. rupress.org/jcb/article/...
#CellCycle #Biochemistry #Chromatin
“Heavy-ion beam-induced mutants of Medakamo hakoo indicate potential associations between photosynthesis and cell size, cell cycle, and cell wall morphology.” Okabe et al. @yojiokabe.bsky.social #Medakamohakoo #greenalgae #photosynthesis #cellcycle #cellsize link.springer.com/article/10.1...
Eudald has used sea anemones & #planaria to study #metabolism & #cellfate. He uncovered nutrient driven quiescence—stem cells slowing down in sync with starvation. A unique glimpse into how #metabolism & #cellcycle co-evolved.
@eudaldpascual.bsky.social @irbbarcelona.org @msarscentre.bsky.social
💡How does nutrition regulate cell cycle in stem cells? Check out our new paper from @prhsteinmetz.bsky.social lab & @msarscentre.bsky.social, out now in
@plosbiology.org (plos.io/48J2o6P)
#SeaAnemone #Nematostella #StemCell #CellCycle #Quiescence #TORsignalling 1/12
📢 UNC BCBP Student Defense Alert! Join us for Derek Bolhuis’ defense: “USP37 Earns Its PH-D, and How It Ensures Cell Cycle Progression” Biochemistry/BP 🗓 Date: Fri., Dec 19, 2025 🕘 Time: 9 AM 📍 Location: MBRB G-202 Mentors: Dr. Nick Brown & Dr. Mike Emanuele #PhD #CellCycle
📢 UNC BCBP Student Defense Alert!
Join us for Derek Bolhuis’ defense:
“USP37 Earns Its PH-D, and How It Ensures Cell Cycle Progression” Biochemistry/BP
🗓 Date: Fri., Dec 19, 2025
🕘 Time: 9 AM
📍 Location: MBRB G-202
Mentors: Dr. Nick Brown & Dr. Mike Emanuele
#PhD #CellCycle
Cyclin-dependent kinases remain central to cell-cycle progression and disease. A comprehensive update on CDK biology and therapeutic relevance.
#CDK #CellCycle #CancerBiology #CellRegulation
www.nature.com/articles/s41...
A proposed model for cell cycle-dependent regulation of BRCA1 protein level in G1 and S phase by the countering activities of APC/CCdh1/Ube2S and Cezanne in K11-linkage specific ubiquitination of BRCA1. Dysregulation of this pathway due to loss of Cezanne or upregulation of Ube2S leads to reduced BRCA1 protein level and is associated with BRCAness in tumors.
Levels of BRCA1 fluctuate through the #CellCycle & its depletion can induce #tumors. This study identifies a new #ubiquitin modification pathway that regulates #BRCA1 stability; its dysregulation is associated with features of BRCA-mutated #BreastCancer @plosbiology.org 🧪 plos.io/4q3cxlT
A proposed model for cell cycle-dependent regulation of BRCA1 protein level in G1 and S phase by the countering activities of APC/CCdh1/Ube2S and Cezanne in K11-linkage specific ubiquitination of BRCA1. Dysregulation of this pathway due to loss of Cezanne or upregulation of Ube2S leads to reduced BRCA1 protein level and is associated with BRCAness in tumors.
Levels of BRCA1 fluctuate through the #CellCycle & its depletion can induce #tumors. This study identifies a new #ubiquitin modification pathway that regulates #BRCA1 stability; its dysregulation is associated with features of BRCA-mutated #BreastCancer @plosbiology.org 🧪 plos.io/4q3cxlT
Top: The phylogenetic position of Nematostella and localization of Vasa2 +/Piwi1+ cells within the juvenile polyp body plan. (A) Simplified phylogenetic tree highlighting the phylogenetic position of the sea anemone Nematostella vectensis and other animal taxa relevant for this study. All animal silhouettes are licensed under CC0,1.0 Universal Public domain and taken from https://www.phylopic.org. (B–D) Schematics showing the localization of Vasa2+/Piwi1+ cells in a juvenile polyp, depicted in longitudinal (B) or cross-section (C, D). (E) Schematic representation of the multipotent, Vasa2+/Piwi1+ stem/progenitor cell population and a simplified summary of their germinal and somatic progeny. (F) Schematics of cell cycle phases, highlighting the incorporation of EdU during S-phase (black line) and the phosphorylation of Histone H3 (pH3+) during metaphase. Bottom: Confocal image of two Vasa+/Piwi+ stem-like cells in the inner epithelial folds of the sea anemone Nematostella vectensis. Immunolabelling of mOrange2-Piwi1 fusion protein (yellow) in a transgenic knock-in line combined with nuclear stain (white). Image credit: Paula Miramón-Puértolas.
How do animals with lifelong growth modulate cell #proliferation? @eudaldpascual.bsky.social @ktgarschall.bsky.social @prhsteinmetz.bsky.social show that starvation induces G1/G0 #CellCycle arrest in Vasa2+/Piwi1+ #SeaAnemone cells; cycle re-entry is TOR-dependent @plosbiology.org 🧪 plos.io/48J2o6P
Top: The phylogenetic position of Nematostella and localization of Vasa2 +/Piwi1+ cells within the juvenile polyp body plan. (A) Simplified phylogenetic tree highlighting the phylogenetic position of the sea anemone Nematostella vectensis and other animal taxa relevant for this study. All animal silhouettes are licensed under CC0,1.0 Universal Public domain and taken from https://www.phylopic.org. (B–D) Schematics showing the localization of Vasa2+/Piwi1+ cells in a juvenile polyp, depicted in longitudinal (B) or cross-section (C, D). (E) Schematic representation of the multipotent, Vasa2+/Piwi1+ stem/progenitor cell population and a simplified summary of their germinal and somatic progeny. (F) Schematics of cell cycle phases, highlighting the incorporation of EdU during S-phase (black line) and the phosphorylation of Histone H3 (pH3+) during metaphase. Bottom: Confocal image of two Vasa+/Piwi+ stem-like cells in the inner epithelial folds of the sea anemone Nematostella vectensis. Immunolabelling of mOrange2-Piwi1 fusion protein (yellow) in a transgenic knock-in line combined with nuclear stain (white). Image credit: Paula Miramón-Puértolas.
How do animals with lifelong growth modulate cell #proliferation? @eudaldpascual.bsky.social @ktgarschall.bsky.social @prhsteinmetz.bsky.social show that starvation induces G1/G0 #CellCycle arrest in Vasa2+/Piwi1+ #SeaAnemone cells; cycle re-entry is TOR-dependent @plosbiology.org 🧪 plos.io/48J2o6P
A proposed model for cell cycle-dependent regulation of BRCA1 protein level in G1 and S phase by the countering activities of APC/CCdh1/Ube2S and Cezanne in K11-linkage specific ubiquitination of BRCA1. Dysregulation of this pathway due to loss of Cezanne or upregulation of Ube2S leads to reduced BRCA1 protein level and is associated with BRCAness in tumors.
Levels of BRCA1 fluctuate through the #CellCycle & its depletion can induce #tumors. This study identifies a new #ubiquitin modification pathway that regulates #BRCA1 stability; its dysregulation is associated with features of BRCA-mutated #BreastCancer @plosbiology.org 🧪 plos.io/4q3cxlT
Top: The phylogenetic position of Nematostella and localization of Vasa2 +/Piwi1+ cells within the juvenile polyp body plan. (A) Simplified phylogenetic tree highlighting the phylogenetic position of the sea anemone Nematostella vectensis and other animal taxa relevant for this study. All animal silhouettes are licensed under CC0,1.0 Universal Public domain and taken from https://www.phylopic.org. (B–D) Schematics showing the localization of Vasa2+/Piwi1+ cells in a juvenile polyp, depicted in longitudinal (B) or cross-section (C, D). (E) Schematic representation of the multipotent, Vasa2+/Piwi1+ stem/progenitor cell population and a simplified summary of their germinal and somatic progeny. (F) Schematics of cell cycle phases, highlighting the incorporation of EdU during S-phase (black line) and the phosphorylation of Histone H3 (pH3+) during metaphase. Bottom: Confocal image of two Vasa+/Piwi+ stem-like cells in the inner epithelial folds of the sea anemone Nematostella vectensis. Immunolabelling of mOrange2-Piwi1 fusion protein (yellow) in a transgenic knock-in line combined with nuclear stain (white). Image credit: Paula Miramón-Puértolas.
How do animals with lifelong growth modulate cell #proliferation? @eudaldpascual.bsky.social @ktgarschall.bsky.social @prhsteinmetz.bsky.social show that starvation induces G1/G0 #CellCycle arrest in Vasa2+/Piwi1+ #SeaAnemone cells; cycle re-entry is TOR-dependent @plosbiology.org 🧪 plos.io/48J2o6P
Looking to start up my blue account again. I am a postdoc based in the Parsons lab at the University of Birmingham (#uob). I have keen interests in how #kinases modulate #cellcycle and #DNAdamage response pathways. I welcome the opperunity to connect with fellow #cellsignalling researchers 🙂
