Cdc5-mediated Ulp2 phosphorylation controls the timing of polySUMOylation during the cell cycle. New study from Emily Gutierrez-Morton, Yanchang Wang and colleagues (Florida State University): rupress.org/jcb/article/...
#Genetics #CellCycle #CellDivision
New Discovery Reveals Unconventional Mechanism of Cell Division in Embryos
🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅
#celldivision #embryonicdevelopment #mechanicalratchet
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Emily Gutierrez-Morton, Yanchang Wang and colleagues show that in yeast, polo-like kinase Cdc5 promotes the phosphorylation of SUMO protease Ulp2, reducing its affinity for SUMO chains and thereby facilitating polySUMOylation. rupress.org/jcb/article/...
#Genetics #CellCycle #CellDivision
In Memoriam: R. Bruce Nicklas (1932-2025). Leocadia Paliulis commemorates the life of Dr. Nicklas who was a mentor, a polymath with a great sense of humor, and a link to the beginnings of chromosome research. rupress.org/jcb/article/...
#CellDivision #Chromosomes
Did you know the Atlas Blue butterfly has 229 pairs of chromosomes? That's a lot to get through during #meiosis! Luckily we have a paper model to help you learn how it works! Find out more here: buff.ly/MasNbof
#EduSky #iteachbio #gametes #haploid #biology #celldivision
Cdc42 accumulates in aged cells, and reducing its levels extends life span.Two representative WT cells expressing Cdc42-mCherrySW are shown at selected ages and time points (hr: min) from initial loading. White arrowheads indicate cells during or shortly after cytokinesis, when Cdc42 levels are quantified. Black and red arrowheads denote the same cells at other cell cycle stages and cell death, respectively. Scale bar: 3 µm.
Cdc42 is a small GTPase crucial for #CellPolarity, but how does it contribute to #aging when upregulated? This study shows that the ER-anchored chaperone Ydj1 interacts with Cdc42, enhancing its stability & partitioning during asymm #CellDivision & aging in yeast @plosbiology.org 🧪 plos.io/4qz7WaM
Cdc42 accumulates in aged cells, and reducing its levels extends life span.Two representative WT cells expressing Cdc42-mCherrySW are shown at selected ages and time points (hr: min) from initial loading. White arrowheads indicate cells during or shortly after cytokinesis, when Cdc42 levels are quantified. Black and red arrowheads denote the same cells at other cell cycle stages and cell death, respectively. Scale bar: 3 µm.
Cdc42 is a small GTPase crucial for #CellPolarity, but how does it contribute to #aging when upregulated? This study shows that the ER-anchored chaperone Ydj1 interacts with Cdc42, enhancing its stability & partitioning during asymm #CellDivision & aging in yeast @plosbiology.org 🧪 plos.io/4qz7WaM
#InMemoriam: Dr. Robert Bruce Nicklas, who spent over 50 years unraveling the mysteries of how #chromosomes move during #CellDivision, died on February 19, 2025, at the age of 92. Leocadia Paliulis commemorates his life and work. rupress.org/jcb/article/...
#InMemoriam @jcb.org: Dr. Robert Bruce Nicklas, who spent over 50 years unraveling the mysteries of how #chromosomes move during #CellDivision, died on February 19, 2025, at the age of 92. Leocadia Paliulis commemorates his life and work. rupress.org/jcb/article/...
Cdc42 accumulates in aged cells, and reducing its levels extends life span.Two representative WT cells expressing Cdc42-mCherrySW are shown at selected ages and time points (hr: min) from initial loading. White arrowheads indicate cells during or shortly after cytokinesis, when Cdc42 levels are quantified. Black and red arrowheads denote the same cells at other cell cycle stages and cell death, respectively. Scale bar: 3 µm.
Cdc42 is a small GTPase crucial for #CellPolarity, but how does it contribute to #aging when upregulated? This study shows that the ER-anchored chaperone Ydj1 interacts with Cdc42, enhancing its stability & partitioning during asymm #CellDivision & aging in yeast @plosbiology.org 🧪 plos.io/4qz7WaM
Early resolution of sister chromatids during #Celegans #meiosis. New study from Antonia Hamrick and Ofer Rog @theroglab.bsky.social @uofubiology.bsky.social: rupress.org/jcb/article/...
#Chromatin #epigenetics #Genetics #CellCycle #CellDivision
Antonia Hamrick and Ofer Rog @theroglab.bsky.social define the organization of the sister chromatids during #meiosis in #Celegans. Sisters are found to occupy distinct volumes when meiotic exchanges form. rupress.org/jcb/article/...
#Chromatin #epigenetics #Genetics #CellCycle #CellDivision
CKS-1 and the choreography of meiotic chromosome segregation. Shabnam Moghareh, David Bojorquez, and Pablo Lara-Gonzalez @ucirvine.bsky.social discuss work from Yang et al. (rupress.org/jcb/article/...) In Spotlight: rupress.org/jcb/article/...
#CellCycle #CellDivision #Development #Meiosis
Anaphase onset requires CKS-1 mediated destruction of securin in #meiosis I and #cyclin B1 in meiosis II, say Jie Yang, Eisuke Sumiyoshi, and Bruce Bowerman @uoregon.bsky.social: rupress.org/jcb/article/...
#CellCycle #CellDivision #Genetics #Celegans
Spotlight @jcb.org: Moghareh, Bojorquez, and Lara-Gonzalez highlight work from Yang et al. (rupress.org/jcb/article/...) showing that CKS-1 plays key roles in both #anaphase B during #oocyte #meiosis I and the #metaphase II–to–anaphase II transition. rupress.org/jcb/article/...
#CellDivision
Spotlight: Moghareh, Bojorquez, and Lara-Gonzalez highlight work from Yang et al. (rupress.org/jcb/article/...) showing that CKS-1 plays key roles in both #anaphase B during #oocyte #meiosis I and the #metaphase II–to–anaphase II transition. rupress.org/jcb/article/...
#CellDivision #Development
Meet Gabrielle Schick, a master's student in the Department of Biology conducting research in Dr. Alisa Piekny’s lab. The lab studies how cells divide using tools like CRISPR and molecular cloning.
#CellDivision #CRISPR #Microscopy
www.youtube.com/watch?v=Qxe1...
Mitosis was described in the 1800's by various scientists... without knowing about DNA. Science works in crazy ways! Our Mitosis & Cell Cycle paper model goes through each step in a clear way! Find out more here: buff.ly/gaGkqlz
#EduSky #mitosis #celldivision #iteachbio
Did you know it takes a human cell only 8 hours to replicate 3 BILLION base pairs of DNA for cell division? Unbelievable. Learn how it happens with our DNA Replication paper model! Find out more here: buff.ly/rJStomA
#EduSky #DNA #DNAreplication #celldivision #mitosis #iteachbio #biologyteacher
Spotlight: Leeds and Asbury preview work from Henriques et al. (rupress.org/jcb/article/...), which describes how #anaphase A and B are mechanically coordinated in #Celegans embryos. rupress.org/jcb/article/...
#Biophysics #CellDivision #Cytoskeleton #Development #Mitosis
Last chance to apply for a PhD Position in our lab on #keratins in #celldivision
Applications close on 7/1/26
🦠 New preprint!
In the radiation-resistant Deinococcus radiodurans, septal PG synthesis during division happens in steps:
SEDS–bPBP starts constriction
Class A PBPs reinforce the wall later.
Thanks for reading — and thanks to the team!
🔗 Preprint: doi.org/10.1101/2025...
#Microbiology #CellDivision
Meet Ioanna Tountas, a master’s student in #Biology in Dr Alisa Piekny’s lab. Her research explores how the mechanisms that control #celldivision change as #stemcells differentiate into other cell types, and how disruptions in these processes can lead to #disease.
www.youtube.com/watch?v=uk0e...
Meiosis: The Unexpected Sequel
Meiosis: The Unexpected Sequel
#Meiosis #Biology #Chromosomes #Celldivision #Genetics
sciencehumor.io/biology-memes/meiosis-th...
Happy to share our latest publication:
CRISPR/Cas9 targeted genetic screening in Physcomitrella identifies novel cell division genes
#moss #Physcomitrella #celldivision
www.frontiersin.org/journals/pla...
Did you know that the 3 billion base pairs of DNA in human cells is copied in about 8 hours? But how? Our DNA Replication paper model shows you how!
Find out more here: buff.ly/a036Nj3
#EduSky #DNAreplication #DNApolymerase #helicase #primase #iteachbio #biologyteacher #genetics #DNA #celldivision
Adapting plasma membrane for mitotic cell rounding through Aurora A phosphorylation of numb. New Study from Yanyan Li, Ke Liu, Xian Lin, Zhihao Ding, Ximing Shao, Hongchang Li (Shenzhen Institutes of Advanced Technology) and colleagues: rupress.org/jcb/article/...
#CellCycle #CellDivision #Mitosis
Learn about Mitosis & Cell Division by making our paper model! See what happens at each stage of #mitosis & how #celldivision happens. Find out more here: buff.ly/xsmJclw
#EduSky #iteachbio #biologyteacher #scienceteacher #cells #chromosomes #nucleus #cytokinesis #interphase #metaphase #prophase
Bni5 regulates and coordinates #septin architecture and #myosin-II functions at the #CellDivision site, say Hiroki Okada, Erfei Bi and colleagues @upenn.edu: rupress.org/jcb/article/...
#Cytoskeleton #CellCycle #Biochemistry #Genetics #Cytokinesis
Yanyan Li, Hongchang Li al. reveal that Aurora A–mediated phosphorylation of Numb triggers its dissociation from the plasma membrane, thereby promoting #myosin I–dependent membrane-to-cortex adhesion required for mitotic cell rounding rupress.org/jcb/article/...
#Mitosis #CellDivision #Genetics
