Epigenetics Update - Functional landscape of non-canonical open reading frames in coordinating cell fate bit.ly/46HXPt8

Jin Chen (University of Texas) reporting in Mol Cell

#Epigenetics #CellFate
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Empower your research with hi-res epigenetic insight at epigenometech.com

Embryonic intestinal Lgr5⁺ cells regulate small intestinal morphogenesis via Hedgehog signaling prior to vilification

Cell Regen Research | Embryonic intestinal Lgr5⁺ cells prior to villification (PVLCs) actively shape small intestinal morphogenesis before villi form via Hedgehog signaling! #Cellfate #IntestinalDevelopment
🔗 Full paper at: doi.org/10.1186/s136...

Congratulations 🎉 to @unger-lucas.bsky.social on successfully defending his PhD with the thesis “Dissecting HNF1A’s Role in Early Cell Fate Decisions and Their Impact on Pancreatic Islet”! 👏 🎓
#cellfate #devbio

Professor Emerita Birgitta Åsjø @unibergen.bsky.social is introducing Lucas @unger-lucas.bsky.social as he starts his PhD work presentation focused on the Dissecting HNF1A’s Role in Early #CellFate Decisions & their Impact on Pancreatic #Islet
@cheralab.bsky.social

#PhDLife #PhDdefense #devbio

Of TOR and Tide: Metabolism Beyond the Model #MetabolismMondays - the Node All the world's a metabolic dance, early career scientists are leading the way! Emerging perspectives in metabolism Dr. Eudald Pascual-CarrerasX:

Eudald has used sea anemones & #planaria to study #metabolism & #cellfate. He uncovered nutrient driven quiescence—stem cells slowing down in sync with starvation. A unique glimpse into how #metabolism & #cellcycle co-evolved.

@eudaldpascual.bsky.social @irbbarcelona.org @msarscentre.bsky.social

Well explained @plosbiology.org , understanding HCT and its transcriptional control opens doors for regenerative liver science.
Stay updated with more such studies on SciOpen: www.sciopen.com

#LiverScience #CellFate #Transdifferentiation #MolecularBiology #SciOpen #TUP 🌐

Epigenetics Update - Generative epigenetic landscapes map the topology and topography of cell fates bit.ly/4515eml

Paul François (Université de Montréal) reporting in PNAS

#Epigenetics #Chromatin #CellFate
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Perfect for cancer, immunology, and aging research; epigenometech.com

Sara Jiménez, @pancint.bsky.social, @molinalab.bsky.social & co use single-cell sequencing approaches to define the developmental differentiation of enteroendocrine cells, which has not yet been done in mice or humans. doi.org/10.1242/bio....

#StemCell #CellFate #Organoid

Really enjoyed visiting CABD (@cabd-upo-csic.bsky.social) in Sevilla last Friday — great discussions and inspiring science. I shared our group’s latest work on #epigenetics, #cellfate, #CRISPR and #leukemia.

Thanks to Ozren (@obog.bsky.social) for being a great host!

Survivin and Aurora Kinase A control cell fate decisions during mitosis

👉 buff.ly/PLDmH38

#AURKA #Mitosis #CellFate

Uncovering what drives cell identity Researchers found that selective RNA sequestration in P-bodies inside the cell directed cell fate transitions.

What drives cell identity? @distefanolab.bsky.social, J. Brumbaugh et al found that selective #RNA sequestration in #Pbodies inside the cell directed #cellFate transitions. @bcmhouston.bsky.social @colorado.edu @natbiotech.nature.com #CPRITTexas
blogs.bcm.edu/2025/10/30/f...

This week: Dr. Tongyu Sun and a team in Dr. Yarui Diao's lab at @dukehealth.bsky.social showed that #TransposableElements act as ‘mechano-response enhancer elements’ that control human #CellFate and #GeneExpression. 🧬

🗒️ @natcellbio.nature.com - https://go.nature.com/3I88AMp
🗣️ https://bit.ly/48I9olK

Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant Abstract. Distal 1q21.1 deletions and duplications are associated with variable phenotypes including autism, head circumference and height defects. To eluc

⭐ NAR Breakthrough! ⭐
New research highlights CHD1L in the chromosome 1q21.1 region—linked to #autism, head size & growth.
🧠 It controls #DNApackaging & genes for #braindevelopment, #cellfate & #connectivity.
Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Neuroscience @igbmc.bsky.social

Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.

Epigenetics Update - Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate bit.ly/46B7YYP

#Epigenetics #SingleCell #CellFate
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Gain deeper insights into gene regulation; epigenometech.com

Metabolic and Nutritional Control of Development and Cell Fate | Keystone Symposia Join us at the Keystone Symposia on Metabolic and Nutritional Control of Development and Cell Fate, May 2025, in Beverly, with field leaders!

Register for on-demand access to @keystonesymposia.bsky.social #Metabolic and #NutritionalControl of Development and #CellFate to explore emerging research in the field. #KSMetabDev25
plos.io/4mfH9z0

Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation This study reveals that composite transposons with bivalent histone marks can serve as RNA-dependent enhancers, controlling key developmental and aging-related gene programs.

Outstanding paper describing how SVAs are regulated,what's their function in gene regulation and its impact in cell fate

Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation | Cell

#TEs #CellFate #HSCs #Aging

www.cell.com/cell/fulltex...

Uncovering how mechanical forces can influence nuclear ATP levels, with downstream effects on DNA damage response and cell cycle progression.

#Mechanobiology #NuclearMetabolism #CellFate #DNArepair #CellCycle

CiRA | Center for iPS Cell Research and Application, Kyoto University CiRA is a world-leading institute focused on iPS cell research to realize applications of iPS cell technology in drug discovery and regenerative medicine.

Celebrating the 20th Anniversary of iPS Cells: Keystone Symposia Conference Highlights the Future of Regenerative Medicine!

#KSiPSCs25 #iPSCs #iPSC #stemcells #cellfate #organoids www.cira.kyoto-u.ac.jp/e/pressrelea...

Thrilled to share with you the latest work from my PhD in Bigas lab at @researchmar.bsky.social @carrerasijc.bsky.social published in @bloodjournal.bsky.social

We’ve programmed blood stem cells from PSCs using CRISPRa screen and found a new “bloody” cocktail

#CRISPR #HSCs #StemCells #CellFate

Bivalent chromatin instructs lineage specification during hematopoiesis Yagi et al. show that, unexpectedly, H3K4 methylation is dispensable for hematopoietic stem cell maintenance but essential for progenitor cell maturation into all blood cell types by opposing H3K27 me...

H3K4 methylation instructs blood specification in vivo

Bivalent chromatin instructs lineage specification during hematopoiesis | Cell

#Hematopoiesis #CellFate #Chromatin

www.cell.com/cell/abstrac...

Postdoc post in my lab from Autumn this year @lsiexeter.bsky.social @exeter.ac.uk
#Chromatin #StemCells #Enhancer #NeuralCrest #Transcription #CellFate
#NuRDIsTheWord
Apply and/or get in touch!

Cells use more than signal strength to decide their fate—they "listen" to the tempo of signaling. Check out this work by our Cellular Computations and Learning Lab introducing signaling homeorhesis, a concept where dynamic signal patterns guide cell decisions. #CellSignaling #cellfate

The Wnt pathway regulates stem cell division, differentiation, and even links to diseases like cancer. This review tracks its evolving roles—and its potential for future therapeutic targeting. doi.org/10.1016/j.ge...
#WntSignaling #CellFate #RegenerativeBiology

📅 Curious for more? Check out our fall Stem Cell Stars seminar lineup and save the dates:

stemcellcenter.lu.se/news/events/...

#StemCellResearch #Hematopoiesis #RegenerativeMedicine #CellFate #ScientificCollaboration #BiomedicalResearch

@jshendure.bsky.socialImpressive piece of work from ‪@jshendure.bsky.social‬ putting gastruloids to work and learning something from them about the clonal implications for #CellFate decisions of the heterogeneity of the starting PSC population www.biorxiv.org/content/10.1... #MustRead

Behold a mouse blastocyst: The earliest glimpse of a mammal’s first cell fate decision!
Green marks future placenta cells.
Red highlights cells fated to become the embryo. Image taken by @VirginiaSavy.bsky.social
#FluorescenceFriday #DevBio #MouseEmbryo #CellFate #ImagingScience 🧪

Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366) | University of Oslo Job title: Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366), Employer: University of Oslo, Deadline: Thursday, May 15, 2025

We are extending the application deadline for this post-doc position! Do not miss the opportunity to join an exciting project in a dynamic and collaborative research environment. @igbmc.bsky.social @pasteur.fr @univbordeaux.bsky.social @uio.no #epigenetics #cellfate #SUMOylation @ncmbm.bsky.social

Of TOR and Tide: Metabolism Beyond the Model #MetabolismMondays - the Node All the world's a metabolic dance, and we are merely moving to the rhythm ! Emerging perspectives in metabolism Dr. Eudald Pascual-CarrerasX:

Of Tor and Tide #MetabolismMondays
Meet @eudaldpascual.bsky.social from @ibe-barcelona.bsky.social & @msarscentre.bsky.social, using sea anemones and #planaria to study #metabolism and #cellfate!

#theNodeCorrespondents #devbio #cellbio @biologists.bsky.social @the-node.bsky.social

This review explores the latest developments in understanding #m6AModification and its potential role in modulating #CellFate transition and pluripotent states of mouse and human #EmbryonicStemCells. #Epigenetics #medsky

#OpenAccess: www.sciencedirect.co...

Showcase your research! Submit your poster abstract by April 16 (11:59pm MST) to join speakers @lydiafinley.bsky.social, Ralph J. DeBeradinis, & Keynote Navdeep Chandel. Apply now: keysym.us/KSMetabDev25. Can't attend? Access insights On Demand for 6 months post-conference!

#KSMetabDev25 #cellfate