Pleased to share new work from us showing effects of elexacaftor/tezacaftor/ivacaftor (ETI) therapy on the function and quality of the T cell compartment in people with cystic fibrosis, both in the airways and systemically.

@ki.se #cysticfibrosis #Tcells #MAIT
rdcu.be/e06Rw

#RAIMO #PULLAT
aepiot.com/advanced-sea...
#UELI #KESTENHOLZ
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#MAIT #LEPIK
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aepiot.ro

@globalvisibility.bsky.social | Woosh @globalvisibility.bsky.social on Woosh - The customizable link page built for the fediverse.

woosh.link/globalvisibi...

#RAIMO #PULLAT
allgraph.ro/advanced-sea...
#UELI #KESTENHOLZ
multi-search-tag-explorer.headlines-world.com/advanced-sea...
#MAIT #LEPIK
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allgraph.ro

better-experience.blogspot.com/2026/01/aepi...

#SOOME #PENSIONISÜSTEEM
allgraph.ro/advanced-sea...
#ARNOLD #SCHÖNBERG
headlines-world.com/advanced-sea...
#MAIT #JOORITS
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#ARNOLD #SCHÖNBERG
multi-search-tag-explorer.aepiot.com/advanced-sea...
#MAIT #JOORITS
aepiot.ro/advanced-sea...
aepiot.ro

New work from LeBlanc, Sobel, Constantinides (@mikerobe.bsky.social) et al. @scripps.edu demonstrates that transient depletion of riboflavin-synthesizing commensals in early life can adversely affect responses to subsequent infections. rupress.org/jem/article/...
#MucosalImmunology #Microbiome #MAIT

In @jem.org, LeBlanc, Sobel, Constantinides et al. @scripps.edu show that antibiotic treatment in early life can deplete riboflavin-synthesizing commensals & impair #MAIT cell development, rendering adult animals more susceptible to bacterial #pneumonia. rupress.org/jem/article/...

#Microbiome

LeBlanc, Sobel, Constantinides et al. @scripps.edu show that antibiotic treatment in early life can deplete riboflavin-synthesizing commensals & impair #MAIT cell development, rendering adult animals more susceptible to bacterial #pneumonia. rupress.org/jem/article/...

#Microbiome

Abdelaal, Gherardin, Rossjohn, @waelawad.bsky.social et al. identified three-ringed isoalloxazines that bind MR1 and reduce surface levels, suggesting a potential role in dampening #MAIT cell immunity. rupress.org/jem/article/...

#InnateImmunity

The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites, say Mohamed Abdelaal, Nicholas Gherardin, Jamie Rossjohn, Wael Awad @waelawad.bsky.social and colleagues @monashuniversity.bsky.social @unimelb.bsky.social: rupress.org/jem/article/...

#InnateImmunity #MAIT

In @jem.org, Abdelaal, @waelawad.bsky.social et al show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation rupress.org/jem/article/...

Abdelaal, Gherardin, Rossjohn, @waelawad.bsky.social et al show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation rupress.org/jem/article/...

New preprint from the lab on our continuing work on #MAIT cells in #AMR! Fantastic collaboration with Duke-NUS & @sandbergjk.bsky.social @ki.se

Mucosal‐Associated Invariant T Cells: Origins, Biological Functions, Diseases, and Therapeutic Targets Mucosa-associated invariant T (MAIT) cells are an evolutionarily conserved class of innate-like T lymphocytes that rely on MR1 molecules to recognize microbial metabolites and play a central role in ...

#Review in #MedComm
Mucosal-Associated Invariant T Cells: Origins, Biological Functions, Diseases, and Therapeutic Targets doi.org/10.1002/mco2...

#AutoimmuneDisease #cancer #Immunotherapy #InfectiousDisease #MAITcell #MR1 #UnconventionalTcell #MAIT

Exciting work from @haeryfarlab.bsky.social! Their latest study explores the role of #MAIT cells in #BladderCancer.

Check out this cutting-edge science in a full open-access article in the Journal for ImmunoTherapy of cancer: jitc.bmj.com/content/13/9...

#JITC #ImmunoSky #MedSky

Publication Alert 📢
Check out our latest article in @sitcancer.bsky.social where we investigate the role of #MAIT cells in #BladderCancer.
t.co/61Ow0cByGc

#JITC @westernu.ca @westernuresearch.bsky.social @schulichmeddent.bsky.social #WesternMNI

MAIT cells promote cancer progression and regulatory T cell accumulation in bladder tumor microenvironment Background Mucosa-associated invariant T (MAIT) cells represent a unique population of innate-like T lymphocytes capable of detecting non-peptide antigens in the context of monomorphic antigen-present...

Excited to share our latest paper published today in @jitcancer. We demonstrate that #MAIT cells are present in #bladder tumors where they exhibit a MAIT17 phenotype, and promote #Treg cell accumulation and cancer progression. @westernu.ca @schulichmeddent.bsky.social @westernuresearch.bsky.social

Jury has reached 9 hours of deliberations in trial over #AlvinCole shooting involving #JosephMensah in 2020. No decision from jury, a lot of discussion throughout trial about police interviews done after shooting by investigators from #MAIT being heresy.

When gating by either antibody (Va7.2+ or Va24Ja18+ for MAIT and NKT respectively) or tetramer (hMR1 5-OP-RU or hCD1d PBS-57+), we didn't find any differential expression of the markers within our spectral flow cytometry panel for cord blood #MAIT or #NKT cells. 12/n

a man in a black shirt is making a funny face with the words we know who 's the favorite . ALT: a man in a black shirt is making a funny face with the words we know who 's the favorite .

Innate-like #Tcells (ILT) integrate innate and adaptive immunity, playing important roles during homeostasis, #infection and inflammation. Our understanding of them during early life period (especially in neonates) is however limited. We were particularly interested in #MAIT, #NKT and #gdtcells 2/n

# BỨT PHÁ GIỚI HẠN BẢN THÂN: 7 BÍ QUYẾT KIẾN TẠO CUỘC SỐNG ĐỈNH CAO TỪ NHỮNG THÓI QUEN NHỎ! 💥 #PhátTriểnBảnThân #SốngĐỉnh #ThayĐổiTưDuy #ThànhCôngBềnVững #MaiT BỨT PHÁ GIỚI HẠN BẢN THÂN: 7 BÍ QUYẾT KIẾN TẠO CUỘC SỐNG ĐỈNH CAO TỪ NHỮNG THÓI QUEN NHỎ! 💥 #PhátTriểnBảnThân #SốngĐỉnh #ThayĐổiTưDuy #ThànhCôngBềnVững #MaiT --- MỞ ĐẦU: HÀNH TRÌNH VƯỢT NGƯỠNG Trong thế giới hiện đại đầy biến động, việc không ngừng phát triển bản thân không còn là lựa chọn—mà là yêu cầu tất yếu để tồn tại và thăng hoa.

# BỨT PHÁ GIỚI HẠN BẢN THÂN: 7 BÍ QUYẾT KIẾN TẠO CUỘC SỐNG ĐỈNH CAO TỪ NHỮNG THÓI QUEN NHỎ! 💥 #PhátTriểnBảnThân #SốngĐỉnh #ThayĐổiTưDuy #ThànhCôngBềnVững #MaiT

BỨT PHÁ GIỚI HẠN BẢN THÂN: 7 BÍ QUYẾT KIẾN TẠO CUỘC SỐNG ĐỈNH CAO TỪ NHỮNG THÓI QUEN NHỎ! 💥 #PhátTriểnBảnThân #SốngĐỉnh #ThayĐổiTưDuy…

Developmental features and unique characteristics of peptide-specific PLZF+ innate-like T cells in mice - Nature Communications Development of T cells in the thymus results in small populations of innate like T cells. Here the authors characterise a population of innate-like T cells in mice engineered to enable MHC class I exp...

🎉 Exciting news! Our paper has finally been published in Nature Communications!

If you’re interested in innate-like T cells, you’ll find this especially exciting.

www.nature.com/articles/s41...

#immunology #bioinformatics #innate_like_T_cells #iNKT #MAIT

Aerial Saw Operations for Tree Trimming Start in Pennsylvania's Challenging Corridors Tree trimming using helicopters begins across Northern and Central Pennsylvania, enhancing power line safety and reliability.

Aerial Saw Operations for Tree Trimming Start in Pennsylvania's Challenging Corridors #United_States #FirstEnergy #Erie #Penelec #MAIT

3 - The Butcher of Heron Road 20 - Mariwa: An Ivian Tale Blindness. Deafness. Finally, she couldn't tell up from down. For those precious few seconds, she felt as if she didn't exist anymore, blown away with the wind and scattered to all corners of the wo...

BoHR Chapter 20 is out! No teaser today, I have things to do! Go read!
#webnovel #webserial #serial #novel #writing #MAIT #whateverelse
www.royalroad.com/fiction/8944...

Our work co-led by @scripps.edu students Dominic & Jonathan shows that microbial tropism determines how metabolites are presented to #MAIT cells!

HawAAI 2025 in full swing. DM me if you are here and want to catch up or get to know each other! #AAI2025 #Immunology2025 #MAIT #immunometabolism 🌺

3 - The Butcher of Heron Road 19 - Mariwa: An Ivian Tale Of the road into what would become the Crimson Grave, only a skeleton remained. Not an ant foraged among the soot, and not a bird swooped across the sky. In that in-between land, even the vegetation...

The final encounter with Menoux begins
Mariwa: An Ivian Tale Arc 3: The Butcher of Heron Road chapter 19 is out, and the end is on the horizon. #novel #serial #webnovel #webserial #writing #MAIT
www.royalroad.com/fiction/chap...

Naruto - Guy's theme (Locrian) YouTube video by LocrianVGM (Locrian and Abstract)

Naruto - Guy's theme (Locrian)

#Naruto #anime #mightguy #might #guy #maitgai #mait #gai #theme #ninja #rocklee #taijutsu #guytheme #character #charactertheme #musictheme #konoha #narutomusic #Locrian #mode #scale #Locrianmode #Locrianscale #アニメ #マイト・ガイ #マイト #ガイ #ロクリアン #テーマ

youtu.be/KtvwAYMUiEs?...

Vandaag, 16 maart 2025, vanaf 23.00 uur in delateavond.nl de onderwerpen

> Straatinterview - week vakantie OF 5 minuten gratis winkelen
> Column #MidasDekkers - de Zeug
> Marjorie Malbons - Stichting #MAIT

Presentatie: @alfredblokhuizen

Vandaag, 14 maart 2025, vanaf 23.00 uur in delateavond.nl de onderwerpen

> Straatinterview - week vakantie OF 5 minuten gratis winkelen
> Column #MidasDekkers - de Zeug
> Marjorie Malbons - Stichting #MAIT

Presentatie: @alfredblokhuizen