Meet 2025 #HUMAINAward winner Dr. Veronica Zingales (University of Valencia).

Her work uses human-specific, nonanimal research models—helping generate more relevant data to protect human health.

Watch her story and learn how human-relevant science is shaping the future. 🎥

#NonanimalMethods

Screenshot from the linked page, showing the paper "Lost in NAMs-lation: A review of animal-free science definitions" by Donna S. Macmillan, Phi Holcomb, and Kristie M. Sullivan. Published as a Benchmarks article in the journal ALTEX.

It’s giving… NAM‑biguity 🧪

#NonAnimalMethods?
#NewApproachMethodologies?

In this timely new paper, Donna Macmillan, Phi Holcomb, and Kristie Sullivan (ICCS & IIVS) take on the great vocabulary swirl of animal‑free science and call for some much-needed clarity.

www.altex.org/index.php/al...

Urgently needed now.
#NonAnimalMethods 🚨

www.news.com.au/technology/i...

Petition: End testing on dogs and other animals for development of products for human use Many tests on dogs and other animals cause unimaginable suffering. They can translate poorly into effective treatments and cures for human diseases or provide safety and efficacy data that is not rele...

Petition to end animal testing, if you have a UK address, please sign and share! Please ensure you confirm your signature by clicking the link you receive in your emails.

petition.parliament.uk/petitions/73...

#EndAnimalTestingNow #ModernScience #NonAnimalMethods #MedicineWithoutCruelty

A light blue graphic with a white quotation mark at the top left and a white starburst at the bottom right. A quote reads: "These innovative approaches will advance safety testing, accelerate drug development, and enhance disease modeling ... Ultimately, this will support more cost-effective and human-relevant results, compared to traditional [read animal] models. - Stacey Adam, PhD, FNIH Vice President of Science Partnerships; fnih.org."

Opportunities are still open to join >40 government, life science, nonprofit, & other organizations in FNIH's Validation and Qualification Network, which aims to accelerate the implementation of #NonAnimalMethods.

Learn more:
fnih.org/news/fnih-pr...

#NAMs 🧪

a man wearing glasses and a hat has the words just think outside of the box below him ALT: a man wearing glasses and a hat has the words just think outside of the box below him

Searches for #NonAnimalMethods should not be limited to peer-reviewed literature. Preprints & ‘grey’ literature like policy reports, newsletters, government documents, white papers, protocols, online forums, & social media, as well as consultations, can provide valuable leads.

🏷️ #WD4AIL #WDAIL #WWAIL #WW4AIL #WorldDayforLaboratoryAnimals #WorldDayforAnimalsinLabs #WorldLabAnimalDay #AnimalMethodsBias #Advocacy #Webinar #ResearchFunding #BiomedicalResearch #nonanimalmethods #organoids #organsonchips

Mitigating Animal Methods Bias in Grant Review, Tip #3: Provide robust justifications for your chosen method

Preempt biased reviews by describing your chosen method’s suitability, advantages over animals, and translational potential. Reviewers who prefer or expect to see animal-based methods will need to be convinced by robust justifications for nonanimal methods, including how it’s better to answer the specific research question than animals and its translational potential to improve human health.

✍ This week’s tip for researchers to mitigate #animalmethodsbias is focused on method justification—how can you demonstrate that #nonanimalmethods are the right choice for your research? 🧪

#peerreview #peerreviewbias #methodsuitability

Animal methods bias, whether caused by personal preferences for animal-based methods or lack of expertise in #NonAnimalMethods, can affect the quality or fairness of nonanimal grant and manuscript #PeerReview.

How ‘animal methods bias’ is affecting research careers Some early-career researchers report feeling pressure to use animal models to meet journal and grant requirements, even in disciplines and projects that don’t require them.

We got some great coverage about #AnimalMethodsBias in @nature.com Careers. Big thanks to Christine Ro's great reporting. Be sure to check it out!

www.nature.com/articles/d41...

#biomedicalresearch 🧪 #peerreviewbias #nonanimalmethods

I don’t stand by someone who supported animal abuse and did nothing to stop it. #NonAnimalMethods

Dynamic42 and research partners present three-organ system to reduce animal testing Dynamic42, ESQlabs, Bayer, and the Placenta Lab developed a three-organ system using organ-on-chip technology to advance research and reduce animal testing.

Dynamic42 and research partners present three-organ system to reduce #animaltesting
Pilot project “Multi Organ Model” successfully completed.
Three-organ model improves prediction of drug response.

dynamic42.com/press-releas...

#human-organ-on-chip-models #nonanimalmethods #science

How researchers can help mitigate animal methods bias in grant peer review

Researchers can: Raise awareness of animal methods bias within your institution and scientific community; Educate and train the scientific community in nonanimal research methods and their value in translational success

Researchers can: Seek funding from appropriate sources; Ensure funding opportunities have appropriate method specifications and reviewer expertise

Researchers can: Provide a robust justification for the use and suitability of the chosen methods to answer your specific research question and impact human health in proposals; Volunteer for reviewer positions and make yourself available to review staff

Are you a researcher using #nonanimalmethods? 🧪
Over the next two months, we will share our recommendations for researchers in greater detail to help you understand your role in addressing #animalmethodsbias in grant #peerreview.

#peerreviewbias #newapproachmethodologies #NAMs

Graphic of a small rodent with the SAO logo and ScienceAdvancement.org and the following quote: “The traditional 3Rs principles of replacement, reduction, and refinement, intended to ethically guide animal testing, has in practice often served to reinforce its continued use rather than to eliminate it." Hamideh Frühwein & Norbert W. Paul. J Transl Med. 2025. doi: 10.1186/s12967-025-06084-3

Frühwein & Paul echo what we've written about the #3Rs (🔗 below): The framework is insufficient. Given the availability of #NonAnimalMethods ( #NAMs) , "animal research may no longer be scientifically necessary or ethically defensible." www.scienceadvancement.org/reflections/...

Comité Scientifique Pro Anima just shared a fantastic resource from a roundtable on the challenges of raising awareness about #NonAnimalMethods (NAMs), esp how to communicate complex #scientific concepts to the general public.

🧵 A few key takeaways...