Epigenetics Update - Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders bit.ly/3ObNmzE
Lluis Morey (University of Miami) reporting in Mol Cell
#Epigenetics #Chromatin #Polycomb #Neurodevelopment
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Gain deeper insights into gene regulation; epigenometech.com
Epigenetics Update - DOT1L provides transcriptional memory through PRC1.1 antagonism go.nature.com/4qh5aXB
Chen Davidovich and Omer Gilan (Monash University) reporting in Nat Cell Biol
#Epigenetics #DOT1L #PolyComb
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Gain deeper insights into gene regulation; epigenometech.com
For anyone interested in #BRD4 and #Polycomb axis in development, please check out 👇 latest preprint from our lab.
Check out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...
🪰 Ready to switch gears and delve into the world of Drosophila? Discover this fascinating study from our #Highlights2025 collection.
📕 Polycomb regulates sleep homeostasis in a specific group of cells in Drosophila brain
➡️ buff.ly/XwcXXu8
#drosophila #polycomb #sleephomeostasis
RESEARCH PAPER: Histone modification cross-talk and protein complex diversification confer plasticity to Polycomb repression
By Bonnet et al., and Jürg Müller
➡️ https://genesdev.cshlp.org/content/40/1-2/43.full
Max Planck Institute of Biochemistry
#polycomb #histone #chromatin #drosophila
Epigenetics Update - Widespread association of Polycomb complex–deposited histone H2A monoubiquitylation with enhancers and neuronal gene regulation bit.ly/4rw5p2I
Arneet L. Saltzman in Sci Adv
#Epigenetics #Polycomb
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Gain deeper insights into gene regulation; epigenometech.com
Epigenetics Update - A chromatin-linked CPL2–PHD2/3 module sustains multiple DNA methylation pathways and Polycomb silencing bit.ly/3LYXKd5
Jian-Kang Zhu reporting in PNAS
#Epigenetics #Chromatin #DNAm #Polycomb #Plants
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Perfect for cancer, immunology, and aging research; epigenometech.com
🌟G&D SPOTLIGHT 🌟
RESEARCH PAPER: Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR–ncPRC1.1
By Wolf van der Meer et al., Jeroen Demmers, Yaser Atlasi and Peter Verrijzer
➡️ https://genesdev.cshlp.org/content/39/5-6/401.abstract
#neurodevelopment #epigenetics #polycomb
RESEARCH PAPER: Dominant-negative effects of Weaver syndrome-associated EZH2 variants
By Deevy et al., Eric Conway and Adrian Bracken
➡️ https://genesdev.cshlp.org/content/39/21-22/1355.full
Eric Conway
Adrian Bracken
#weaversyndrome #ezh2 #polycomb #mutation #congenitaldisorder #onthecover
Epigenetics Update - VEL-dependent polymerization maintains the chromatin association of Polycomb proteins for the switch to epigenetic silencing bit.ly/4p0x6Qb
#Epigenetics #Polycomb #Chromatin
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High-resolution insights without cell sorting; epigenometech.com
Epigenetics Update - SKP1A bound to Polycomb-silenced genes mediates degradation of PRC2 and preconditions their activation bit.ly/45A6DB9
Haruhiko Koseki (RIKEN/Chiba University) reported in Mol Cell
#Epigenetics #Polycomb #Chromatin
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Gain high-res epigenetic insights at epigenometech.com
Previous studies showed that MLL2 is essential for #H3K4me3 deposition at #bivalent promoters, which has been proposed to facilitate the induction of major developmental genes during pluripotent cell differentiation by antagonizing #polycomb mediated repression
Epigenetics Update - The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice go.nature.com/4lPspqq
#Epigenetics #KDM2A #GermCells #Polycomb
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High-resolution insights without cell sorting; epigenometech.com
🆕 New publication from the Tchasovnikarova Lab!
CRAMP1 drives linker histone expression to enable Polycomb repression 🧬
Read the full study in Molecular Cell:
🔗 sciencedirect.com/science/arti...
#Epigenetics #Chromatin #GeneRegulation #Polycomb #GurdonInstitute #SBS_Cambridge
Epigenetics Update - CRAMP1 drives linker histone expression to enable Polycomb repression bit.ly/44fy7v8
Iva A. Tchasovnikarova (University of Cambridge) reporting in Mol Cell
#Epigenetics #Polycomb
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Empower your research with high-res epigenetic insights at epigenometech.com
Beautiful and important work by the group of @yichenglong.bsky.social at Weill Cornell on the molecular determinants that direct epigenetic repression by Polycomb complexes. www.biorxiv.org/content/10.1... #epigenetics #stemcells #cardiogenesis #polycomb
Very cool! #Transcriptome #Nuclear #Compartments #Speckles #Polycomb
Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag: Molecular Cell www.cell.com/molecular-ce...
We hypothesize that these temperature-dependent dynamics alter the #chromatin structure from a modality active for #transcription to a state that can be #Polycomb silenced.
We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...
Nuova frontiera nella ricerca sui tumori: l'epigenetica rivelata come innesco chiave
www.digitalmente.cloud/2024/04/26/r...
#alterazioni #dna #epigenetica #geni #mutazioni #neoplasie #oncogeni #origine #polycomb #ricerca #strategie #sviluppo #terapie #tumori #tumorigenesi
News about Cancer:
These data show that a reversible depletion of #Polycomb #proteins
➡️ can induce #cancer in the absence of driver mutations, suggesting that #tumours can emerge
➡️ through #epigenetic #dysregulation leading to
➡️ inheritance of altered cell fates.
www.nature.com/articles/s41...
Who would have guessed that Milei recognized the importance of #Drosophila melanogaster's hind legs? #Polycomb #Antennapedia #Neurosensory (and much more!)
The least knowledgeable could think that he was defending the bikini guy, but that doesn't make any sense because he's dead
