What if the real #breakthrough isn’t stopping #ProteinAggregation, but intelligently redirecting its pathway? Explore the insightful review: doi.org/10.63654/icm... #Sustainable #TherapeuticInnovation #AmyloidAggregation #ProteinMisfolding #ComputationalBiology #NeurodegenerativeDiseases

Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly - Nature Communications Inhibiting alpha-synuclein self-assembly into amyloid structures, associated with Parkinson’s disease, is a potential therapeutic intervention. Here, the authors identify the domains/sequences that ar...

Designer foldamers are helping researchers map how α-Synuclein forms toxic aggregates in Parkinson’s Disease.

By identifying the regions that drive harmful clustering, new therapeutic targets are emerging.

t.ly/OKx34

#ParkinsonsResearch #ProteinAggregation #rPeptide

The kinetics of aggregation of the Aβ1-40 peptide monitored by magnetooptical methods Protein misfolding leads to the formation of amyloid fibrils, which presence is characterized for many serious diseases affecting millions of people w…

New research maps how #BetaAmyloid 1-40 aggregates over time, showing how factors like temperature shape fibril formation in Alzheimer’s disease.

#rPeptide Beta-Amyloid 1-40 (A-1001) was used to track aggregation kinetics and morphology.

t.ly/d4COq

#Neuroscience #Alzheimers #ProteinAggregation

Parkinson's Disease: The Epidemiology, Risk Factors, Molecular Pathogenesis, Prevention, and Therapy This graphical abstract summarizes the major components of this review on Parkinson's disease, including epidemiological trends, risk factor classification, peripheral and molecular pathogenesis, and...

#Review in #MedComm
Parkinson's Disease: The Epidemiology, Risk Factors, Molecular Pathogenesis, Prevention, and Therapy doi.org/10.1002/mco2...

#α_synuclein #BloodTransfusion #Gut_brainAxis #ProteinAggregation #ParkinsonsDisease #PD

In Vitro Evaluation of Amide-Linked Coumarin Scaffolds for the Inhibition of α‑Synuclein and Tau Aggregation Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most prevalent neurodegenerative disorders characterized by continuous loss of functional neurons. The numbers of AD and PD patients will likely double by 2060 and 2040, reaching 13.9 and ...

New research shows coumarin-based small molecules can slow Tau and Alpha-Synuclein aggregation — a potential path for early AD/PD intervention. Tested using rPeptide’s recombinant proteins (S-1001, T-1001).

t.ly/KGkxl

#NeuroScience #AD #PD #ProteinAggregation #rPeptide

Model for RQC impacts on aging in aneuploid cells. Healthy cells maintain ubiquitin stasis as part of the Ubiquitin-Proteasome System (UPS). We propose that defects in RQC either produce or indirectly cause protein aggregates that sequester ubiquitin, thereby depleting the pool of accessible ubiquitin,

Why do disorders caused by chromosomal #aneuploidy, like #DownSyndrome, involve premature #aging? This study shows that #chromosome amplification in yeast causes defects in the #ribosomeQC pathway, leading to #ProteinAggregation & aging @plosbiology.org 🧪 plos.io/4rliUT0

Model for RQC impacts on aging in aneuploid cells. Healthy cells maintain ubiquitin stasis as part of the Ubiquitin-Proteasome System (UPS). We propose that defects in RQC either produce or indirectly cause protein aggregates that sequester ubiquitin, thereby depleting the pool of accessible ubiquitin,

Why do disorders caused by chromosomal #aneuploidy, like #DownSyndrome, involve premature #aging? This study shows that #chromosome amplification in yeast causes defects in the #ribosomeQC pathway, leading to #ProteinAggregation & aging @plosbiology.org 🧪 plos.io/4rliUT0

Model for RQC impacts on aging in aneuploid cells. Healthy cells maintain ubiquitin stasis as part of the Ubiquitin-Proteasome System (UPS). We propose that defects in RQC either produce or indirectly cause protein aggregates that sequester ubiquitin, thereby depleting the pool of accessible ubiquitin,

Why do disorders caused by chromosome amplification, like #DownSyndrome, involve premature #aging? This study shows that #chromosome amplification in yeast causes defects in the #ribosomeQC pathway, leading to #ProteinAggregation & aging @plosbiology.org 🧪 plos.io/4rliUT0

In Jan 2026 we will organize the 3rd Dutch protein aggregation network (DPAN) symposium in Amsterdam: we invite Dutch researchers interested in (disease-related) protein aggregation to join the meeting! Registration and other info: dpan-nl.org/3rd-dpan-sym... #amyloid #proteinaggregation

Aggregation dynamics of a 150 kDa Aβ42 oligomer: Insights from cryo electron microscopy and multimodal analysis. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.024

🔗 Aggregation dynamics of a 150 kDa Aβ42 oligomer: Insights from cryo electron microscopy and multimodal analysis. Computational and Structural Biotechnology Journal, doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#CryoEM #ProteinAggregation #Biophysics #StructuralBiology #Alzheimers #Neuroscience

Our group presented our work at the New Horizons in Neurodegeneration 2025 (NHND 2025) in Leuven/Brussels 🇧🇪.
Pictured: our student Ihor Kozlov at the conference venue. Great discussions and inspiring science! #NHND2025 #neuroscience #proteinaggregation #research

Fluorescent 'Zoom Lens' Detects Early Protein Changes Linked to Disease

Rice University created AnapTh, a fluorescent amino acid probe that detects micro‑environment shifts in live cells, showing early aggregation hotspots (Sept 10 2025). Read more: getnews.me/fluorescent-zoom-lens-de... #proteinaggregation #nanoprobes

Ambroxol displaces α-synuclein from the membrane and inhibits the formation of early protein-lipid coaggregates
Carles, E., Dreier, J. E. et al.
Paper
Details
#AmbroxolResearch #NeurodegenerativeDiseases #ProteinAggregation

HAPLN2 forms aggregate-like structures in the cerebellar white matter of aged mice. Top: Representative images of fluorescence immunohistochemistry of the mouse cerebellum showing HAPLN2, myelin basic protein (MBP, a marker for myelinated axons), and 4′,6-diamidino-2-phenylindole (DAPI). n = 3. Bottom: Magnified fluorescence immunohistochemistry images for HAPLN2 corresponding to the boxed areas in the left panels. n = 3.

#ProteinAggregation is a hallmark of #neurodegeneration. This study shows that HAPLN2 aggregates in the aging brain, triggering #inflammation; microglial clearance regulates HAPLN2 buildup. This links protein accumulation to immune activation in healthy #aging @plosbiology.org 🧪 plos.io/4fJy7YG

HAPLN2 forms aggregate-like structures in the cerebellar white matter of aged mice. Top: Representative images of fluorescence immunohistochemistry of the mouse cerebellum showing HAPLN2, myelin basic protein (MBP, a marker for myelinated axons), and 4′,6-diamidino-2-phenylindole (DAPI). n = 3. Bottom: Magnified fluorescence immunohistochemistry images for HAPLN2 corresponding to the boxed areas in the left panels. n = 3.

#ProteinAggregation is a hallmark of #neurodegeneration. This study shows that HAPLN2 aggregates in the aging brain, triggering #inflammation; microglial clearance regulates HAPLN2 buildup. This links protein accumulation to immune activation in healthy #aging @plosbiology.org 🧪 plos.io/4fJy7YG

HAPLN2 forms aggregate-like structures in the cerebellar white matter of aged mice. Top: Representative images of fluorescence immunohistochemistry of the mouse cerebellum showing HAPLN2, myelin basic protein (MBP, a marker for myelinated axons), and 4′,6-diamidino-2-phenylindole (DAPI). n = 3. Bottom: Magnified fluorescence immunohistochemistry images for HAPLN2 corresponding to the boxed areas in the left panels. n = 3.

#ProteinAggregation is a hallmark of #neurodegeneration. This study shows that HAPLN2 aggregates in the aging brain, triggering #inflammation; microglial clearance regulates HAPLN2 buildup. This links protein accumulation to immune activation in healthy #aging @plosbiology.org 🧪 plos.io/4fJy7YG

What separates harmless from harmful protein aggregates? A recent study in The FASEB Journal links changes in PABPN1 structure to muscle cell dysfunction in OPMD—highlighting key differences between wild-type and expanded variants.
🔗 buff.ly/i34Ot9v
#MuscleBiology #ProteinAggregation #FASEBJournal

CANYA AI Decodes the Language of Sticky Proteins A groundbreaking AI model trained on 100,000 synthetic protein sequences reveals new insights into what makes proteins clump, opening the door to better drugs and deeper understanding of diseases like Alzheimer’s.

AI learns the language of sticky proteins. A breakthrough for Alzheimer’s, biotech, and beyond. #AIinBiotech #ProteinAggregation #Neurodegeneration

🙌 Huge thanks to all authors, and to Phospho Biomedical Animation for the stunning cover!

📚 Full issue: pubs.acs.org/toc/jacsat/1...
📄 Paper: pubs.acs.org/doi/10.1021/...

@radford-lab.bsky.social @naranson.bsky.social

#amyloid #chemsky #diabetes #proteinaggregation

(6/6)

It was a pleasure to host Prof. Dr. Paolo Arosio from @ethzurich.bsky.social, who gave a fascinating talk on "Engineering Enzymatic Reactions and Protein Aggregation with Biomolecular Condensates." #BiomolecularCondensates #PhaseSeparation #EnzymaticReactions #ProteinAggregation

Frontiers | Exploring proinsulin proteostasis: insights into beta cell health and diabetes

Our first article on proinsulin proteostasis from ETSU. 😊
www.frontiersin.org/journals/mol...
Testament to great efforts by undergraduate students in my lab! 🙋🏻‍♂️
#proteinfolding #diabetes #proteinaggregation #insulin #proinsulin #ERqualitycontrol #proteostasis

Online now - the Spotlight "Balancing act: lipid-to-protein ratios steer the aggregation fate of #αsynuclein" from Christian Blum and Mireille Claessens.

#LipidMembranes #ProteinAggregation #Amyloid

authors.elsevier.com/a/1kgCK3S6Gf...

Available online - the Review "PARPs and ADP-ribosylation-mediated #biomolecularcondensates: determinants, dynamics, and disease implications" from @leunglab.bsky.social and colleagues.

#phaseseparation #proteincondensation #proteinaggregation

Free access at: authors.elsevier.com/a/1kZlO3S6Gf...

So excited to have finally made it to a FENS-Hertie Winter School in Austria! Arrived to see everyone in post-dinner working group mode. The learning never stops!🥳🧠

#FENSSchool on #proteinaggregation and its consequences in #neurodegenerativedisorders
#Hertie

@lucbuee.bsky.social & Susanne Wegmann

Hello #neuroscience community. I am an Assistant Professor at IISER-Thiruvananthapuram working on Parkinson's disease biology. Looking to connect with other researchers in the field of #neurodegeneration
#movementdisorders #parkinson #proteinaggregation #HiSciSky #AcademicSky

Scientists at #UniMainz and @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases...

Forschende von #UniMainz u @imbmainz schlagen Konzept einer #Proteinaggregation|suhr zur Messung von #Alterung u #Gesundheit vor / Neue Möglichkeit zur Bestimmung des Risikos altersbedingter Krankheiten...

Research Article: Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis -Protein Science

#proteinaggregation #misfolding #proteinfolding #proinsulin #disulfidebonds #betacells #Diabetes

onlinelibrary.wiley.com/doi/full/10....