Congratulations to our National Cancer Institute scholarship awardees: Anamica Das, Natalia Pinello Gini, Eleni Liapi, Benedetta Ricci, Fu Xu & Kohki Yamada.
The future of RNA biology and epitranscriptomics looks bright! ✨
#RNA #RNAModifications #Epitranscriptomics #CancerResearch
accumulation of the 50S subunit in delta-tlyA with cold sensitive phenotype and resistance to aminoglycosides 🦠 #RNAmodifications #RNAbiology #rnasky
Signature codon usage patterns define functional gene families, this is in yeast and could be also very informative for bacteria and link with tRNA modifs #rnasky #codonusage #rnabiology #rnamodifications
The last manuscript from the lab is out there!!! We found that #RNAmodifications are involved in the #antiviralresponse in the context of #celiacdisease suggesting potential therapeutic interventions.
rdcu.be/eYn7S
Latest review highlights how #RNAmodifications influence gut immune balance and disease development, positioning them as promising therapeutic targets in #Inflammatory and neoplastic #GutDisorders. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
RMPore: a comprehensive database of single-molecule RNA modifications detected by Nanopore direct RNA sequencing. #RNAmodifications #Nanopore #DirectRNAseq #Bioinformatics #Genomics #NAR @narjournal.bsky.social 🧪🧬 🖥️
academic.oup.com/nar/advance-...
Don't miss out on other great Reviews!
📝 The role membranes play in #Huntington's disease is Reviewed by Justin Legleiter
📝 Sebastian Glatt et al Review how #RNAmodifications in ribosomes can be mapped to high resolution
(3/n)
Establishing benchmarks for quantitative mapping of m6A by Nanopore Direct RNA Sequencing. #DirectRNAseq #RNAsequencing #RNAmodifications #m6A #Genomics #Bioinformatics @nanoporetech.com 🧪🧬 🖥️
www.biorxiv.org/content/10.1...
Establishing benchmarks for quantitative mapping of m6A by Nanopore Direct RNA Sequencing. #DirectRNAseq #Sequencing #RNAmodifications @nanoporetech.com
www.biorxiv.org/content/10.1...
DirectRM: integrated detection of landscape and crosstalk between multiple RNA modifications using direct RNA sequencing. #DirectRNAseq #RNAmodifications @nanoporetech.com #Sequencing @natcomms.nature.com 🧪🧬 🖥️
www.nature.com/articles/s41...
Happy to share our new review in Royal Society Open Biology 🎉
tRNA-modifying enzymes in bacterial stress adaptation:
How tRNA mods rewire translation under oxidative + antibiotic stress (MoTTs, moonlighting, therapy angles).
Read: doi.org/10.1098/rsob...
#RNAsky #microsky #AMR #RNAmodifications
Mapping rRNA, tRNA, and mRNA modifications in ribosomes at high resolution. #RNAmodifications #RibosomalRNA #Genomics @cp-trendsbiochem.bsky.social
www.cell.com/trends/bioch...
Today, #WorldCancerResearchDay, we received the visit from Casa Real and AECC. We are grateful for the recognition we received and the interest shown in the research lines of our laboratory. We continue working to overcome challenges in cancer research.
#RNACancer
#RNAModifications
Hoy #WorldCancerResearchDay hemos recibido la visita de La Casa Real y la AECC. Agradecemos el reconocimiento otorgado y el interés mostrado en las líneas de trabajo de nuestro laboratorio. Seguimos esforzándonos para superar retos en investigación contra el cáncer.
#RNACancer
#RNAModifications
📝 Online now - the Review "Mapping rRNA, tRNA, and mRNA modifications in ribosomes at high resolution" from Lukasz Koziej and Sebastian Glatt.
#RNAmodifications #epitranscriptomics #TranslationRegulation #CodonBias #TherapeuticTargeting
Read it here: authors.elsevier.com/a/1lnYa3S6Gf...
🚨 New study out @natcellbio.nature.com!
We show how the microbial metabolite preQ1 shapes host physiology through tRNA modification and regulating translation.
Check it out 👉 nature.com/articles/s41...
👏 Huge congrats to the whole team!
#Translation #Queuine #MicrobialMetabolites #RNAmodifications
Enhanced detection of RNA modifications in Escherichia coli utilizing direct RNA sequencing. #RNAmodifications #directRNAsequencing #Nanopore #Sequencing @nanoporetech.com @cp-cellrepmethods.bsky.social 🧬 🖥️
www.cell.com/cell-reports...
The human RNome project meeting report is now live!
Prepared by myself and fellow ECRs @bennetthenzeler.bsky.social and @ramibechara.bsky.social
Check it out 🧬
humanrnomeproject.org/2025-worksho...
#RNAmodifications #MassSpec #nanopore
Systematic benchmarking of basecalling models for RNA modification detection with highly-multiplexed nanopore sequencing. #DirectRNAsequencing #DRS #RNAmodifications #Nanopore #Genomics #Bioinformatics #ModelBenchmarking #Basecalling @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
The final session of day 3 of our #LongTREC summer school. Leda Katopodi talks all things epitranscriptomics. She covers detection of RNA modifications, differential analysis, biological implications and more!
#Epitranscriptomics #RNAModifications #TransferRNA #tRNA
Differential RNA modification analysis using nanopore dRNA-seq reveals exciting new insights into beta-cell glucose response. #RNAModifications #LongReadTranscriptomics #DirectRNA #dRNA #Nanopore
Left: Coronal brain sections of control (top), heterozygous (middle) and knockout (bottom) mice at E13.5 were stained with antibodies recognizing BrdU and Ki67. Pregnant mothers received a BrdU pulse 24 h before embryo collection. Representative cortical regions were shown. Scale bar, 50 μm. Right: A model in which the m5C reader protein Ybx1 regulates the stability of transcripts of key cell cycle regulatory proteins, and its loss leads to impaired proliferation and differentiation in cortical progenitor cells. Image credit: Jian Zhang
What is the role of m5C #RNAmodifications during neural development? This study shows that m5C reader protein Ybx1 plays a crucial role in promoting #CellCycle progression of embryonic cortical #ProgenitorCells, essential for proper cortical development @plosbiology.org 🧪 plos.io/3SUN4we
Left: Coronal brain sections of control (top), heterozygous (middle) and knockout (bottom) mice at E13.5 were stained with antibodies recognizing BrdU and Ki67. Pregnant mothers received a BrdU pulse 24 h before embryo collection. Representative cortical regions were shown. Scale bar, 50 μm. Right: A model in which the m5C reader protein Ybx1 regulates the stability of transcripts of key cell cycle regulatory proteins, and its loss leads to impaired proliferation and differentiation in cortical progenitor cells. Image credit: Jian Zhang
What is the role of m5C #RNAmodifications during neural development? This study shows that m5C reader protein Ybx1 plays a crucial role in promoting #CellCycle progression of embryonic cortical #ProgenitorCells, essential for proper cortical development @plosbiology.org 🧪 plos.io/3SUN4we
Left: Coronal brain sections of control (top), heterozygous (middle) and knockout (bottom) mice at E13.5 were stained with antibodies recognizing BrdU and Ki67. Pregnant mothers received a BrdU pulse 24 h before embryo collection. Representative cortical regions were shown. Scale bar, 50 μm. Right: A model in which the m5C reader protein Ybx1 regulates the stability of transcripts of key cell cycle regulatory proteins, and its loss leads to impaired proliferation and differentiation in cortical progenitor cells. Image credit: Jian Zhang
What is the role of m5C #RNAmodifications during neural development? This study shows that m5C reader protein Ybx1 plays a crucial role in promoting #CellCycle progression of embryonic cortical #ProgenitorCells, essential for proper cortical development @plosbiology.org 🧪 plos.io/3SUN4we
We're excited to share in this Symposium on #RNAmodifications. Join us! @ukresearch.bsky.social
Helena Santos Rosa presented her fascinating work today at @cambiochem.bsky.social , exploring how RNA modifications contribute to cancer resistance mechanisms. Amazing job diving into the molecular details—well done, Helena! 🧬👏 #RNAmodifications #CancerResearch @gurdoninstitute.bsky.social
Proud to be part of this interdisciplinary work with @sebastianglatt.bsky.social, Ting-Yu Lin, our teams at @MCB_UJ & @IIMCB_Warsaw, and collaborators from France! #cryoEM + #biophysics + #modeling reveal how #pseudouridine shapes human tRNA structure and stability. 🧬 #RNAmodifications
