Ivermectin, Fenbendazole and Mebendazole Protocol in Cancer: Peer-Reviewed Protocol in Cancer We are pleased to announce that the first-of-its-kind protocol utilizing Ivermectin, Mebendazole, and F...

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Pick one. Routine or impulse? Which do you prefer? Tell me now. Be present. Decide with structure. #Submission #Protocol

Protocol for recording visual maps in the mouse superior colliculus and visual cortex with intrinsic optical imaging #protocol #starprotocols #cellpress

Protocol for quality control screening of brain organoid morphology #protocol #starprotocols #cellpress

Your best investment is a clip made for you. proper session. Tell me what you want denied. iwantclips.com/custo... #CustomVideo #Protocol

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Evaluation of the Comparative Efficacy of an Ayurvedic Formulation (Nimba-Amalakyadi Powder) vs Metformin in the Management of Type 2 #Diabetes Mellitus: #Protocol for a Pilot #Study Background: In Ayurveda, (#Diabetes mellitus) is considered (one among eight diseases difficult to treat and cure). (three bio-humor in Ayurveda) with certain metabolic factors are involved in its pathogenesis. Frequent urination is a common symptom of this disease. #Diabetes mellitus can be confused with type 2 #Diabetes mellitus in conventional science due to the resemblance in cardinal features. Objective: The primary objectives of this pilot #Study are to assess feasibility through recruitment, retention, adherence, data completeness, and participant acceptability. It also aims to estimate variability in outcome measures like fasting blood sugar and glycated hemoglobin (HbA). The secondary, exploratory objective is to observe trends in these clinical indicators to inform effect size assumptions for future trials. Methods: In this pilot #Study 36 individuals with type 2 #Diabetes mellitus will be recruited and split into two equal groups at random. In Group A (Control), metformin tablets (500 mg) will be prescribed daily once before lunch with plain water for 45 consecutive days. In Group B (Interventional group), the formulation will be prescribed 5 grams twice daily with an empty stomach (ie, 7 AM-5 PM) with lukewarm water for 45 consecutive days. Follow-up will be taken on days 45 and 90 to #Study the sustained effect of the drug. Results: The preliminary analysis of participant responses began in January 2025. Final results from this phase are expected to be available by June 2025. Recruitment rate (number recruited/month), eligibility rate (number eligible/number screened), retention rate at 45 days, compliance with intervention (percentage of prescribed doses taken), adherence to follow-up investigations, acceptability of intervention (based on participant-reported feedback), and data completeness rates are variables. Moreover, changes in the objective parameters, ie, reductions in blood sugar level (fasting and postprandial) and HbA values of patients will be also observed and recorded. Conclusions: A conclusion will be drawn according to the clinical findings obtained at baseline and follow-up visits with biochemical reports of the patients. The trial will prove the feasibility and comparative efficacy of formulation versus metformin tablets for the management of type 2 #Diabetes mellitus Trial Registration: The Clinical Trials Registry- India (CTRI) CTRI 2021/08/036034; https://tinyurl.com/2xwc84p2 International Registered Report Identifier (IRRID): PRR1-10.2196/63574

JMIR Res Protocols: Evaluation of the Comparative Efficacy of an Ayurvedic Formulation (Nimba-Amalakyadi Powder) vs Metformin in the Management of Type 2 #Diabetes Mellitus: #Protocol for a Pilot #Study

Protocol for generation of brain metastasis mouse model using stereotactic intracranial tumor-derived cells and modified intracarotid injection #protocol #starprotocols #cellpress

Prevalence and Patterns of Ocular Surface #Disease Among Glaucoma #Patients on Topical #Medications: A Prospective Comparative Cross-Sectional #Study #Protocol Date Submitted: Mar 7, 2026. Open Peer Review Period: Mar 9, 2026 - May 4, 2026.

Reminder>> Prevalence and Patterns of Ocular Surface #Disease Among Glaucoma #Patients on Topical #Medications: A Prospective Comparative Cross-Sectional #Study #Protocol (preprint) #openscience #PeerReviewMe #PlanP

Re-exploring adult cochlear implant assessment referrals in the United Kingdom (CIRCA-2): #Study #Protocol for a national multicentre retrospective observational #Study Date Submitted: Mar 8, 2026. Open Peer Review Period: Mar 9, 2026 - May 4, 2026.

Reminder>> Re-exploring adult cochlear implant assessment referrals in the United Kingdom (CIRCA-2): #Study #Protocol for a national multicentre retrospective observational #Study (preprint) #openscience #PeerReviewMe #PlanP

Comparing Surgical Outcomes of Sodium Hyaluronate Versus Hypromellose as Ophthalmic Viscosurgical Devices in Topical Phacoemulsification Among Diabetic #Patients with Cataract: A Prospective Comparative Interventional Cohort #Study #Protocol Date Submitted: Mar 9, 2026. Open Peer Review Period: Mar 10, 2026 - May 5, 2026.

Reminder>> Comparing Surgical Outcomes of Sodium Hyaluronate Versus Hypromellose as Ophthalmic Viscosurgical Devices in Topical Phacoemulsification Among Diabetic #Patients with Cataract: A Prospective Comparative Interventional Cohort #Study #Protocol (preprint) #openscience #PeerReviewMe #PlanP

Incidence and Anatomical Distribution of Primary Posterior Capsular Opacity During Cataract #Surgery in a Rural Population: Prospective Observational #Study #Protocol Date Submitted: Mar 8, 2026. Open Peer Review Period: Mar 9, 2026 - May 4, 2026.

Reminder>> Incidence and Anatomical Distribution of Primary Posterior Capsular Opacity During Cataract #Surgery in a Rural Population: Prospective Observational #Study #Protocol (preprint) #openscience #PeerReviewMe #PlanP

Protocol to analyze steps of ribosome biogenesis in nuclear and cytosolic fractions of yeast cells #protocol #starprotocols #cellpress

Methods of Analysis in Randomized Noninferiority Trials: Methodological Survey Review #Protocol Background: Noninferiority (NI) trial designs that investigate whether an experimental intervention is no worse than the standard of care have been used increasingly in recent years. The robustness of the conclusions depends in part on the analysis population set used. In NI settings, the intention-to-treat (ITT) and per-#Protocol (PP) analysis sets are most common. The ITT analysis has been considered anticonservative compared with the PP analysis. Objective: This #Study aimed to conduct a methodological review assessing the analysis population sets used in contemporary NI trials. Methods: A comprehensive electronic search strategy will be conducted to identify studies indexed in MEDLINE, Embase, Emcare, and Cochrane CENTRAL. Studies will be included if they are NI trials published in 2024. The primary outcome is the analysis population used for the primary analysis of the trial (ITT, PP, or as-treated). Secondary outcomes include the NI margin, effect estimates, point estimates, and corresponding CIs. Analyses will be performed using descriptive statistics. Results: The comprehensive search initially identified 1209 studies, of which 403 trials were eligible for data extraction. Data extraction began in January 2025 and is expected to be completed in January 2026. Conclusions: This methodological survey of NI trials will describe the analysis population used in the primary analysis and assess factors that may be associated with each analysis method. Trial Registration: PROSPERO CRD420251021089; https://www.crd.york.ac.uk/PROSPERO/view/CRD420251021089 International Registered Report Identifier (IRRID): DERR1-10.2196/76876

JMIR Res Protocols: Methods of Analysis in Randomized Noninferiority Trials: Methodological Survey Review #Protocol

Cardiovascular Health and Financial Hardship: #Protocol for a Qualitative Citizen Science #Study Background: Cardiovascular disease (CVD) is the leading cause of death worldwide. Individuals with lower income or experiencing financial hardship face a significantly higher risk of developing CVD. However, there is a lack of in-depth insight into their experiences with CVD, and specific attention to women is essential. Objective: The In a Heartbeat #Study aims to understand the relationship between CVD and financial hardship and enable earlier recognition and prevention of CVD among both women and men. In this #Study #Protocol, we describe our citizen science #Study, in which we unravel the mechanisms and contexts through which financial problems lead to the development and late recognition of CVD. Methods: The main data for this #Study are collected by citizen scientists through qualitative lifeline interviews. All citizen scientists have experience with financial hardship, and some also have experience with CVD. We hold weekly project team meetings with citizen scientists and professional scientists in which we use methods such as photo elicitation, critical-creative hermeneutic analysis, design thinking, a dynamic learning agenda, and regular individual and group evaluations of the citizen science process. Results: The #Study was funded in October 2024 and started in January 2025. Data collection started in November 2025 and is expected to end halfway through 2026. Four qualitative lifeline interviews had been conducted as of December 6, 2025. Data analyses are planned for 2026. Manuscripts reporting findings on the central #Research question and the process evaluations will be submitted for publication in 2027. Conclusions: Toward the end of the #Study in 2027, we will develop and disseminate concrete recommendations for various stakeholders to prevent CVD and recognize CVD earlier among people with financial hardship. In all our analyses and recommendations, we will consider sex and gender differences. Our #Study could contribute to a reduction in health inequalities. International Registered Report Identifier (IRRID): DERR1-10.2196/89101

JMIR Res Protocols: Cardiovascular Health and Financial Hardship: #Protocol for a Qualitative Citizen Science #Study

Evaluation Models for Undergraduate Nursing Clinical Skills: A Scoping Review #Protocol Background: Undergraduate nursing students are expected to perform a high-stakes clinical skills test, which ultimately determines their ability to engage in clinical practice. With intake number of students growing nationally, clinical instructors are modifying these skills tests to be shorter in duration as an attempt to meet scheduled class times, severely decreasing the assessments’ accuracy and increasing student stress. Objective: The objectives of this review are to examine best practices of evaluation structures or models for undergraduate nursing students participating in clinical skills-based assessments as part of their program curriculum to explore alternative, best-practice methods for evaluating key clinical skills. The goal is to use what is known in the literature to help inform the development of a new evidence-based clinical skills evaluation model that is adaptive to student population growth, enhances student learning and faculty teaching experiences, and ensures safe patient care. Methods: This scoping review will consider studies involving nursing students enrolled in an undergraduate nursing degree program who undergo clinical skills testing as part of their degree fulfillment. Original articles published in English from January 1, 2015, to present day will be included. This review will follow the Joanna Briggs Institute methodology for scoping reviews, as well as the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. The literature search will use the following databases: SCOPUS, CINAHL, Medline, PsycInfo, ProQuest Central, and ProQuest Dissertations and Theses to identify relevant sources. Moreover, nonempirical #Research, such as editorials, opinion papers, gray literature, and reviews, will be included. Data from professional nursing organizations, including the College of Nurses of Ontario (CNO), the Registered Nurses’ Association of Ontario (RNAO), and the Canadian Association of Schools of Nursing (CASN), will be considered. Two independent reviewers will conduct a screening of article titles and abstracts, followed by full-text reviews. Together, they will determine which articles will proceed to the data extraction stage. If discrepancies arise, a consensus discussion will take place between the two reviewers with assistance from a third reviewer. Results: The project was funded in June 2025 (Figure 1). The scoping review is scheduled to begin in July 2025, with the literature search and #Study selection processes planned through Fall 2025. Results are expected to be submitted for publication in Winter 2026. Conclusions: The results of this review will summarize the current breadth of knowledge on clinical skills testing and best-practice methods used for clinical skill evaluation among undergraduate nursing students. Any gaps in the literature will be identified as these can be used to guide future #Research within this area of nursing education. Trial Registration: OSF Registries osf.io/k7rv4; https://osf.io/k7rv4 International Registered Report Identifier (IRRID): PRR1-10.2196/79805

JMIR Res Protocols: Evaluation Models for Undergraduate Nursing Clinical Skills: A Scoping Review #Protocol

Reminder>> The Effect of Integrated Aerobic and Cognitive Training (Activ4Brain) on Cognition and Neurophysiology in Older Adults: #Protocol for a Controlled Trial (preprint) #openscience #PeerReviewMe #PlanP

Developing and Validating Measures of Structural Ableism to Improve Health Outcomes for the Disability Community: #Protocol for a Mixed Methods #Study Background: Structural ableism, defined as the processes, policies, and institutions that privilege able-bodied people over disabled people, is a root cause of health inequalities faced by the disability community. Unlike other forms of structural oppression, there are currently no adequate measurements for structural ableism and its impacts. Therefore, a necessary first step to addressing health inequities that impact the disability community is to create validated measures of structural ableism. Objective: This paper outlines the methods of an ongoing project that aims to develop and validate measures of structural ableism. The resulting measures will facilitate the identification of relationships between structural ableism and health outcomes at both an individual and community level. Methods: This project will take place across 3 phases. In Phase I, we will characterize the multiple factors that comprise the construct of structural ableism. We will begin by analyzing texts that discuss historical events, ideologies, and the lived experiences of disabled people to inform our understanding of contemporary dimensions of structural ableism. Simultaneously, key informant interviews with advocates and activists from the disability rights and disability justice movements will be conducted to further characterize the dimensions of structural ableism. In Phase II, the findings of Phase I will be used to inform the creation of an individual-level measure of structural ableism. Phase III will result in community-level measures of structural ableism, which will be developed using community-engagement studios with members of the disability community and publicly available datasets. This phase will build on the findings of the first 2 phases. Our methods purposefully include disabled people across all phases of this work, with a focus on maximizing the diversity of disability perspectives by including people across disability types and intersecting identities (eg, race and ethnicity, gender identity, geographic location, and other identities and demographics). Most importantly, our approach is deeply community-informed, drawing on multiple community partnerships from local and national organizations, a diverse advisory committee of disabled activists, advocates, and scholars, as well as #Researchers with expertise in developing measures of structural oppression, such as structural racism. Results: This project was funded in August of 2024. As of October 2025, our team has read more than 50 texts as part of our historical and policy analysis of the factors that characterize structural ableism. We plan to complete our characterization of structural ableism in the spring of 2026, with individual-level measures of structural ableism being developed by the Winter of 2028 and community-level measures created by the Winter of 2029. Conclusions: The measures developed by this work will lay the foundation for identifying and evaluating novel interventions aimed at dismantling structural ableism, which should be cocreated with the disability community.

JMIR Res Protocols: Developing and Validating Measures of Structural Ableism to Improve Health Outcomes for the Disability Community: #Protocol for a Mixed Methods #Study

Protocol for stable cell line production to express muscle-type nicotinic receptor #protocol #starprotocols #cellpress

Model Context Protocol (MCP) vs. AI Agent Skills: A Deep Dive into Structured Tools and Behavioral Guidance for LLMs In recent times, many developments in the agent ecosystem have focused on enabli...

#Agentic #AI #AI #Agents #Editors #Pick #Model #Context […]

[Original post on marktechpost.com]

Reminder>> Immersive 3D Simulation vs. Physical Models in Training Novices for Laser-based Endourological Procedures - #Research #Protocol for a #RCT #ClinicalTrial (preprint) #openscience #PeerReviewMe #PlanP

Reminder>> "Strengths, Limitations, and Distinct Characteristics of VR and Actor-Based Simulation in ##MedicalEducation #mededu: #Protocol for a Scoping Review" (preprint) #openscience #PeerReviewMe #PlanP

Protocol for immunofluorescence detection and quantitative analysis of pH-dependent transcriptional condensates #protocol #starprotocols #cellpress

Protocol for the quantification of digestive exophagy in cell culture #protocol #starprotocols #cellpress

Protocol for large-scale, high-yield, high-purity extracellular vesicle purification from human plasma #protocol #starprotocols #cellpress

Whatever it is, it's stupid.
#protocol #JailTrump

Protocol to measure protein half-life in cell culture using heavy water #protocol #starprotocols #cellpress

Clinical Efficacy Evaluation of Tuina Combined Medicated Oil in the Treatment of Nonspecific Low Back Pain: #Protocol for a #RCT #ClinicalTrial Background: Nonspecific low back pain (NSLBP) is a significant global public health concern that affects the health and well-being of individuals across different age groups, limiting their daily activities and reducing their quality of life. As Tuina (Chinese therapeutic massage) therapy and medicated oil are widely used in China, it is necessary to design a randomized clinical trial to assess the effectiveness of Tuina combined medicated oil (TNO) in treating NSLBP. Objective: This #Study aims to evaluate the efficacy and safety of Tuina therapy combined with medicated oil in treating NSLBP. Methods: One hundred participants will be enrolled and randomly allocated to either a TNO group (n=50) or a Tuina combined water group (n=50). Treatment will last for 4 weeks, with sessions 3 times a week, followed by a 4-week follow-up. The visual analog scale score is the primary outcome; secondary outcomes include the evaluation of treatment Japanese Orthopaedic Association scores, infrared thermography, muscle tension tests, and tenderness scores. All adverse reactions will be recorded. Results: The trial commenced in June 2023 and is expected to conclude in September 2025. In June 2025, key preliminary steps were completed, and the ethical review and clinical trial registration were concluded. Recruitment is proceeding as planned, with 100 participants enrolled to date. Data collection is underway, while formal data analysis has not yet commenced. Conclusions: The project’s purpose is to evaluate the effectiveness of TNO in alleviating pain and improving lumbar function in patients with NSLBP. Trial Registration: ChiCTR ChiCTR2300076144; https://www.chictr.org.cn/hvshowproject.html?id=247247 International Registered Report Identifier (IRRID): DERR1-10.2196/81887

JMIR Res Protocols: Clinical Efficacy Evaluation of Tuina Combined Medicated Oil in the Treatment of Nonspecific Low Back Pain: #Protocol for a #RCT #ClinicalTrial

International Clinical Practice Guidelines on Traditional Chinese Medicine Therapy for Dysmenorrhea: Development #Protocol Background: Traditional Chinese medicine (TCM) functions according to the concepts of “holism” and treatment based on syndrome differentiation, and it has achieved good clinical results in treating patients with dysmenorrhea, which is a common gynecological disorder. However, there are currently no international clinical practice guidelines involving TCM therapies for dysmenorrhea. This #Study aims to establish a #Protocol for the development of such guidelines. Objective: This #Protocol will provide a road map for the development of the first international clinical practice guidelines on TCM therapy for dysmenorrhea. Methods: The guidelines will be developed with reference to the and the . They will be developed in accordance with the Appraisal of Guidelines for #Research and Evaluation II and the World Health Organization guideline handbook and will make recommendations based on systematic reviews. We have established a guideline working group and will formulate clinical questions using the participants, interventions, comparisons, outcomes, and #Study design framework. The recommendations will be developed through evidence retrieval, synthesis, and the Delphi method. We will consider the preferences and values of patients, as well as the costs and the pros and cons of interventions. Results: This work was supported by the National Key R&D Program of China (grant 2019YFC1712000) in 2019. The writing group for guidelines was formed in January 2021. The literature search and screening process began in May 2022. So far, the literature search and 2 rounds of the Delphi method have been completed. The #Protocol will provide a road map for the development of the first international clinical practice guidelines on TCM therapy for dysmenorrhea. Conclusions: The guideline will be developed in accordance with this #Protocol, which may provide support and evidence for TCM treatment in patients with dysmenorrhea. There is currently a need for clinical practice guidelines in TCM for the treatment of dysmenorrhea. International Registered Report Identifier (IRRID): DERR1-10.2196/77423

JMIR Res Protocols: International Clinical Practice Guidelines on Traditional Chinese Medicine Therapy for Dysmenorrhea: Development #Protocol

A Supportive Group Intervention for Caregivers to Patients Diagnosed With Glioblastoma: #Protocol for the SUGRI #Study Background: Caregivers to a person diagnosed with a glioblastoma often face significant responsibilities, balancing the demands of care with the complexities of the disease and treatment trajectory, while also coping with concerns and uncertainty of the future. Caregivers report unmet needs of information and support throughout the patient’s disease and treatment trajectory, and they may benefit from targeted supportive care interventions. Objective: The aim of this #Study is to develop, test, and evaluate the feasibility of a supportive group intervention among caregivers to patients diagnosed with a glioblastoma. Methods: The #Study consists of 3 phases with ongoing patient and public involvement (PPI). In the first phase, a systematic review will be carried out exploring the outcome of supportive group interventions for caregivers to patients diagnosed with a primary brain tumor. In the second phase, the design and development of the intervention will be conducted in cooperation with a panel of caregivers using PPI process. The third phase will include the feasibility and evaluation of the intervention. The #Study will be guided by the British Medical #Research Council’s framework for developing complex interventions. The feasibility of the intervention will be tested in reference to relevant parameters. Quantitative data in terms of questionnaires will be analyzed using descriptive statistics, and qualitative evaluation interviews will be analyzed using thematic analysis. Results: A national panel of caregivers (N=10) has been established, and the final design of the intervention is currently developed through an ongoing PPI process. A total of 3 hospitals in Denmark have committed to participating in the recruitment for the feasibility #Study. Recruitment began in April 2025, and the SUGRI (Supportive Group Intervention for caregivers to patients diagnosed with a glioblastoma) intervention will undergo a feasibility assessment in a multicenter #Study starting in August 2025, with the final evaluation planned for April 2026. Conclusions: This #Study is expected to provide necessary insights to guide caregiver initiatives, ultimately improving support for caregivers within the neuro-oncology field. A supportive group intervention offered to the caregivers has the potential to address specific caregiver needs and strengthen their supportive network. Providing caregivers with support may enhance their perceived support, strengthen family functioning, and provide them with strategies to manage caregiving challenges, ultimately benefiting both caregivers and patients. Trial Registration: ClinicalTrials.gov NCT06869577; https://clinicaltrials.gov/#Study/NCT06869577

JMIR Res Protocols: A Supportive Group Intervention for Caregivers to Patients Diagnosed With Glioblastoma: #Protocol for the SUGRI #Study