Pyk2 plays a critical role in #synaptic dysfunction during the early stages of #AlzheimersDisease
Quentin Rodriguez, Floriane Payet, Karina Vargas-Baron...Alain Buisson #hippocampus #amyloid
link.springer.com/article/10.1...
Fast weight programming and linear transformers: from machine learning to neurobiology
Kazuki Irie, Samuel J. Gershman
Action editor: Robert Legenstein
https://openreview.net/forum?id=TDG8EkNmQR
#rnns #synaptic #rnn
Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs | Science Advances www.science.org/doi/10.1126/...
#circRNAs #circHomer1 #plasticity #neuroscience #RNAgranules #synaptic #mRNA #circularRNA
Circular #RNA circHomer1 mediates #hippocampal functions via ribonucleoprotein granule transport and #dendritic targeting of #synaptic RNAs | Science Advances www.science.org/doi/10.1126/...
𝗦𝗰𝗶𝗲𝗻𝘁𝗶𝘀𝘁𝘀 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝘁𝗵𝗮𝘁 𝗿𝗲𝗷𝘂𝘃𝗲𝗻𝗮𝘁𝗲𝘀 𝗮𝗴𝗶𝗻𝗴 𝗯𝗿𝗮𝗶𝗻 𝗰𝗲𝗹𝗹𝘀 [via Science.org] 🧪🥼🧓🧠🩺🧒
"DMTF1 is down-regulated in telomere dysfunctional NSCs and that its up-regulation rescues the defect"
www.science.org/doi/10.1126/...
#telomere #erosion #synaptic #plasticity #aging #brain #health #DMTF1
Top: UNC-11 ∆AD synapses exhibit enlarged synaptic vesicles and abnormal endosome-like structures. Representative transmission electron micrographs of synapses from wild-type N2, unc-11 mutants, Full-length UNC-11-rescued, and UNC-11∆AD-rescued unc-11 mutants. Dense projections are highlighted in orange. The arrow marks an endosome-like structure (ELS, >100 nm in diameter). Scale bar, 100 nm. Bottom: UNC-11 condensates promote the growth of F-actin. Full-length UNC-11 (UNC-11 FL) was labeled with Pacific Blue (cyan), and F-actin was visualized using Alexa Fluor 488–phalloidin (yellow). G-actin (2 µM) and phalloidin (0.2 µM) were added to samples containing UNC-11 droplets, and fluorescence images were collected every 3 min for 48 min. Scale bar, 5 µm.
How does AP180 regulate #SynapticVesicles during #neurotransmission? This study shows that AP180's assembly domain regulates #synaptic #vesicle size & release fidelity in #Celegans via actin binding, revealing how vesicle morphology influences neurotransmission @plosbiology.org 🧪 plos.io/3OcO4g4
Top: UNC-11 ∆AD synapses exhibit enlarged synaptic vesicles and abnormal endosome-like structures. Representative transmission electron micrographs of synapses from wild-type N2, unc-11 mutants, Full-length UNC-11-rescued, and UNC-11∆AD-rescued unc-11 mutants. Dense projections are highlighted in orange. The arrow marks an endosome-like structure (ELS, >100 nm in diameter). Scale bar, 100 nm. Bottom: UNC-11 condensates promote the growth of F-actin. Full-length UNC-11 (UNC-11 FL) was labeled with Pacific Blue (cyan), and F-actin was visualized using Alexa Fluor 488–phalloidin (yellow). G-actin (2 µM) and phalloidin (0.2 µM) were added to samples containing UNC-11 droplets, and fluorescence images were collected every 3 min for 48 min. Scale bar, 5 µm.
How does AP180 regulate #SynapticVesicles during #neurotransmission? This study shows that AP180's assembly domain regulates #synaptic #vesicle size & release fidelity in #Celegans via actin binding, revealing how vesicle morphology influences neurotransmission @plosbiology.org 🧪 plos.io/3OcO4g4
Top: UNC-11 ∆AD synapses exhibit enlarged synaptic vesicles and abnormal endosome-like structures. Representative transmission electron micrographs of synapses from wild-type N2, unc-11 mutants, Full-length UNC-11-rescued, and UNC-11∆AD-rescued unc-11 mutants. Dense projections are highlighted in orange. The arrow marks an endosome-like structure (ELS, >100 nm in diameter). Scale bar, 100 nm. Bottom: UNC-11 condensates promote the growth of F-actin. Full-length UNC-11 (UNC-11 FL) was labeled with Pacific Blue (cyan), and F-actin was visualized using Alexa Fluor 488–phalloidin (yellow). G-actin (2 µM) and phalloidin (0.2 µM) were added to samples containing UNC-11 droplets, and fluorescence images were collected every 3 min for 48 min. Scale bar, 5 µm.
How does AP180 regulate #SynapticVesicles during #neurotransmission? This study shows that AP180's assembly domain regulates #synaptic #vesicle size & release fidelity in #Celegans via actin binding, revealing how vesicle morphology influences neurotransmission @plosbiology.org 🧪 plos.io/3OcO4g4
Aprendi a usar o Synaptic quando eu usava Ubuntu Gnome. Instalei no Linux Mint porque de vez em quando preciso dele para achar uns pacotes.
🔬 #Mifobio2025
Flavie LAVOIE-CARDINAL's lecture is online !
🎤 Decoding synaptic diversity with AI-assisted nanoscopy
📹 👉 youtu.be/dRWEcaO77uI
@flc-lab.bsky.social @ulaval.ca @cnrs.fr @cnrsbiologie.bsky.social @cnrsingenierie.bsky.social
@gdr-imabio-ysn.bsky.social
#nanoscopy #synaptic #ai
#Hippocampal delivery of SynCav1 at symptomatic stages in #AlzheimersDisease mouse models preserves memory, restores #synaptic signaling, downregulates #neurodegeneration pathways, and upregulates #CognitivePathways. @uofcalifornia.bsky.social
#STTT: doi.org/10.1038/s413...
Interesting read on how chunking can emerge directly from #synaptic dynamics: by temporarily suppressing groups of items via synaptic augmentation, #WorkingMemory can retrieve up to 8 items despite a base capacity of only 4.
New #Survey Certification:
Fast weight programming and linear transformers: from machine learning to neurobiology
Kazuki Irie, Samuel J. Gershman
https://openreview.net/forum?id=TDG8EkNmQR
#rnns #synaptic #rnn
Highlight #5:
"Enter the Void" by #Synaptic
My AOTY. Dug its claws early and never let go. Yes, my favorite track is the outro. It's that good.
synapticmetal.bandcamp.com/track/embrac...
Ingo H. Greger and Jake F. Watson of mrclmb.bsky.social observed that ‘Mini analysis’ misrepresents changes in #synaptic properties due to incomplete #event detection✍️ 🔎
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Proteomic subtyping of #Alzheimer's disease CSF links blood–brain barrier dysfunction to reduced levels of tau and #synaptic biomarkers - Bangs - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
#Research by Zsuzsanna Fekete et al. investigated #synaptic communication within the microcircuits of pyramidal neurons and basket cells in the mouse #prefrontal cortex ⚙️ 🧠
📜 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔸Women showed higher levels of #synaptic biomarkers.
🔸Men showed higher levels of biomarkers linked to #neurodegeneration, #glial activation, and #vascular dysregulation.
🔸#CSF biomarkers are more indicative of #amyloid accumulation in the brain of women
This study by Yaroslav E. Andrianov et al. finds that activation of TRPA1 and TRPM3 triggers Ca2+ waves in central terminals of sensory #neurons and facilitates #synaptic activity in the spinal dorsal horn ⚙️ 🧠
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Here is what a SOLIS #synaptic network can do for #visualcomputing.
A cycle of memroy writting and progressive erasing using Kesterite-based synapses. Patterns and edge detection are the first step for a proof of concept of #neuromorphic visual computing!
The full code will be released next year.
Kun-Han Lin of mpi-nat.bsky.social et al. found that the number and relative abundance of #synaptic vesicles in functionally distinct priming states determine synaptic strength and short-term #plasticity ⚙️ 🧠
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
In this study, Olusoji A. T. Afuwape of ualittlerock.bsky.social et al. examined persistence of quantal #synaptic vesicle recycling in virtual absence of #dynamins ♻️ 🧠
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Manon M. M. Berns et al. observed that independently engaging protein tethers of different length enhance #synaptic vesicle trafficking to the #plasma membrane 🧠 🔎
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
In this #TopicalReview, Hrach Asmerian et al. examine the role of adaptor #protein complexes in generating functionally distinct #synaptic vesicle pools ✍️ ⚙️
🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🧠💥 #Alzheimer’s kills more than #Breast + #Prostate cancer combined! Our review shows how #AdipoRon may fight #Neuroinflammation, #Tau, & #Synaptic loss!🚀 @MDPIOpenAccess @IJMS_MDPI #NeuroprotectiveFuture #ADresearch
www.mdpi.com/1422-0067/26...
Eliminate unwanted proteins at synapse = ↆ synaptic dysfunction? “…boosting levels of ...protein PI31 can prevent neuronal #degeneration, restore #synaptic function, and significantly extend lifespan ...of rare genetic disorders similar to #Parkinson’s. “ bit.ly/4hlmrvJ bit.ly/3L7pxaJ
