Schematic overview of the findings of the publication by Suarez-Csrmona et al.
New publication on the role of #macrophages in shaping the tumor #microenvironment in #cancer ... leading to the exploration of #adipose tissue and it's impact on #innateimmunity and #adaptiveimmunity in #ovariancancer to the point where resistancr to […]
[Original post on mstdn.science]
#Medsk🧪 #immunosky #publichealthThe "paradox"of immune conservation lies in a fascinating contradiction for decades,we believed that complex #adaptiveimmunity was a "modern" #eukaryotic invention.The molecular blueprints of our immune sys are actually ancient, shared with the very bacteria we fight
Using the HlaH35A-PA0833 #FusionAntigen, this study provides mechanistic insights into how HlaH35A acts as a carrier protein that shapes #AdaptiveImmunity by modulating cDC2 differentiation via ADAM10-Notch2 signaling.
#STTT #OpenAccess: doi.org/10.1038/s413...
This week's #WednesdayCoffeeTalk will be about the #NobelPrize2025 in Medicine and Physiology: Christian Peschel will talk to us about "The role of regulary T cells in #adaptiveimmunity."
Join us on Wednesday at 1 p.m. - it's online, so please send us a DM if you would like the Zoom access info.
This is a call for experts in #AI, #MachineLearning, #DeepLearning, #AdaptiveImmunity, #Immunoinformatics, #Bioinformatics and #ComputationalBiology to join the challenge and help advance on a crucial #immunology problem with applications in diagnostics and therapeutics.
This is a call for experts in #AI, #MachineLearning, #DeepLearning, #AdaptiveImmunity, #Immunoinformatics, #Bioinformatics and #ComputationalBiology to join the challenge and help advance on a crucial #immunology problem with applications in diagnostics and therapeutics.
Left: Model dynamics. (i) Breastfeeding and complementary feeding introduce human milk oligosaccharides (HMOs), plant-derived polysaccharides (PDPs), (ii) mSIgA, and (iii) commensal bacteria to the gut lumen as SIgA-bacteria complexes or bacteria alone, alongside with the bacteria seeding the infant’s gut during vaginal birth. (iv) Bacterial populations modulate the inflammatory tone of the microenvironment of the gut lumen , (v) influencing epithelial cell-mediated communication with the organized gut-associated lymphoid tissue (GALT) inductive sites, and (vi) the antigenic sampling through barrier integrity. (vii) SIgA-bound and unbound antigens sampled by Microfold (M) cells (viii) activate the naïve B cells, and (ix) drive the balance between antigen-specific regulatory vs. helper T cells (indicated by the divide sign). (x) This balance and shape the selection threshold for taxon , (xi) which determines the BCR affinity ranges that lead to different B cell fates: (xii) apoptosis, (xiii) continued circulation, or (xiv) terminal differentiation into IgA-secreting plasma cells. (xv) IgA secreted by the plasma cells regulates the microbiome via (xvi) masking and (xvii) neutralization functions. Alongside the HMOs and PDPs, (xviii) the oxygen concentration (O2) also influences the ecological dynamics based on commensals’ metabolism. Bottom right: GC reactions (steps 1–7, materials and methods, corresponding to (x)–(xiv) on the previous panel).
How does the developing #ImmuneSystem learn which #microbes to tolerate and which to resist? @jessmetcalf.bsky.social &co develop a mechanistic model of early-life interactions between the gut #microbiome & #AdaptiveImmunity, showing how immune tolerance is shaped @plosbiology.org 🧪 plos.io/4lsJ8i5
Left: Model dynamics. (i) Breastfeeding and complementary feeding introduce human milk oligosaccharides (HMOs), plant-derived polysaccharides (PDPs), (ii) mSIgA, and (iii) commensal bacteria to the gut lumen as SIgA-bacteria complexes or bacteria alone, alongside with the bacteria seeding the infant’s gut during vaginal birth. (iv) Bacterial populations modulate the inflammatory tone of the microenvironment of the gut lumen , (v) influencing epithelial cell-mediated communication with the organized gut-associated lymphoid tissue (GALT) inductive sites, and (vi) the antigenic sampling through barrier integrity. (vii) SIgA-bound and unbound antigens sampled by Microfold (M) cells (viii) activate the naïve B cells, and (ix) drive the balance between antigen-specific regulatory vs. helper T cells (indicated by the divide sign). (x) This balance and shape the selection threshold for taxon , (xi) which determines the BCR affinity ranges that lead to different B cell fates: (xii) apoptosis, (xiii) continued circulation, or (xiv) terminal differentiation into IgA-secreting plasma cells. (xv) IgA secreted by the plasma cells regulates the microbiome via (xvi) masking and (xvii) neutralization functions. Alongside the HMOs and PDPs, (xviii) the oxygen concentration (O2) also influences the ecological dynamics based on commensals’ metabolism. Bottom right: GC reactions (steps 1–7, materials and methods, corresponding to (x)–(xiv) on the previous panel).
How does the developing #ImmuneSystem learn which #microbes to tolerate and which to resist? @jessmetcalf.bsky.social &co develop a mechanistic model of early-life interactions between the gut #microbiome & #AdaptiveImmunity, showing how immune tolerance is shaped @plosbiology.org 🧪 plos.io/4lsJ8i5
Left: Model dynamics. (i) Breastfeeding and complementary feeding introduce human milk oligosaccharides (HMOs), plant-derived polysaccharides (PDPs), (ii) mSIgA, and (iii) commensal bacteria to the gut lumen as SIgA-bacteria complexes or bacteria alone, alongside with the bacteria seeding the infant’s gut during vaginal birth. (iv) Bacterial populations modulate the inflammatory tone of the microenvironment of the gut lumen , (v) influencing epithelial cell-mediated communication with the organized gut-associated lymphoid tissue (GALT) inductive sites, and (vi) the antigenic sampling through barrier integrity. (vii) SIgA-bound and unbound antigens sampled by Microfold (M) cells (viii) activate the naïve B cells, and (ix) drive the balance between antigen-specific regulatory vs. helper T cells (indicated by the divide sign). (x) This balance and shape the selection threshold for taxon , (xi) which determines the BCR affinity ranges that lead to different B cell fates: (xii) apoptosis, (xiii) continued circulation, or (xiv) terminal differentiation into IgA-secreting plasma cells. (xv) IgA secreted by the plasma cells regulates the microbiome via (xvi) masking and (xvii) neutralization functions. Alongside the HMOs and PDPs, (xviii) the oxygen concentration (O2) also influences the ecological dynamics based on commensals’ metabolism. Bottom right: GC reactions (steps 1–7, materials and methods, corresponding to (x)–(xiv) on the previous panel).
How does the developing #ImmuneSystem learn which #microbes to tolerate and which to resist? @jessmetcalf.bsky.social &co develop a mechanistic model of early-life interactions between the gut #microbiome & #AdaptiveImmunity, showing how immune tolerance is shaped @plosbiology.org 🧪 plos.io/4lsJ8i5
Accurate and scalable multi-disease classification from adaptive immune repertoires
Haruna, S., Hauer, F. et al.
Paper
Details
#ImmuneRepertoire #MultiDiseaseClassification #AdaptiveImmunity
Published in PLOS Pathogens with Marius Zeeb and Alexandra Trkola. These results deepen our understanding of HIV/MTB co-infection and open paths for novel immunological diagnostics.
#Immunology #HIV #Tuberculosis #HostPathogen #USZ #AdaptiveImmunity #SwissHIVCohort
The Tiny Warriors of Your Immune System: How Our Body Fights Infections
#ImmuneSystem #VaccineScience #SpikeProteins #Antibodies #InnateImmunity #AdaptiveImmunity #StressAndHealth #CytokineStorm #GutHealth #MentalHealthAndImmunity #ImmunityBoost #WellnessTips
youtube.com/shorts/Tzz4-...
This has been primarily observed in highly immunocompromised patients, such as those with cancer, undergoing immunosuppressive treatment, or who have received a transplant. However, the #adaptiveimmunity itself has not been associated with high within-host diversity in immunocompetent subjects.
#Adaptation is a hot word suddenly, don't let me stop it please do let it trend, let it be understood #adaptiveimmunity is our #acquiredimmunity and it is #autoimmunityselfhealing #trustyourbody and it's innate healing ability and to shift with the atmospheric shifts
Fabulous
@shockjournal
paper detailing TEMPORAL CHANGES IN INNATE AND ADAPTIVE IMMUNITY DURING... : Shock journals-lww-com.ezproxy.bu.edu/shockjournal... #innateimmunity #adaptiveimmunity #sepsis #immunology
Join the next (sugar)science Th1nk Tank! 🚨
🔬 iReceptor & the T1D AIRR Consortium with Brian Corrie, PhD
📅 April 3, 2025 | 12 PM ET
🔗 Register: us02web.zoom.us/meeting/regi...
#T1D #DiabetesResearch #AIRR #iReceptor #Immunogenomics #Bioinformatics #AdaptiveImmunity #BCR #TCR
#adaptiveimmunity, #aquiredimmunity All disease is actually a call for healing, are natural healing processes were weaponized, especially autoimmune Cancer and HIV #11:11
#Medsky🧪 #IDsky #oncosky #immunosky #publichealth Review the Pros & Cons of #Trainedimmunity in chronic inflammatory diseases and #cancer . Immunological memory has traditionally been considered an exclusive property of #adaptiveimmunity,
Step into the spotlight alongside Keynote Speaker Antonio Lanzavecchia by presenting your own short talk! To seize this opportunity, submit your abstract and/or scholarship application by January 30 (11:59pm MST). youtu.be/W5naij8S6KQ
#KSBCells25 #BCells #CD4 #adaptiveimmunity #vaccinology
Sign up for our B Cells conference by Jan. 7th (11:59pm MST) and enjoy a $200 discount. Don't miss the chance to connect with Antonio Lanzavecchia and a stellar lineup of speakers this February in the stunning Monte Carlo, Monaco! keysym.us/KSBCells25 #KSBCells25 #BCells #adaptiveimmunity
The question: intracellular #microbes potently induce #inflammasomes & #pyroptosis. How does a DC sense that a cell died under 'suspicious circumstances', & needs its corpse antigens sampled? More broadly, how do #inflammasomes enable the transition to #AdaptiveImmunity? (2/13)
@pebsedwards.bsky.social is investigating how #AdaptiveImmunity may protect against cancer in #LynchSyndrome. Using novel T-cell repertoire sequencing, her early results suggest clonal expansions in response to LS-specific neoantigens. Excited to see how this work develops!
#CancerResearch #PhD
Implications of Adaptive Immune System: Altered T and B cell phenotypes have been observed in ME/CFS patients, suggesting their involvement in pathogenesis. Treg cells, responsible for immune regulation, may play a role. #AdaptiveImmunity
Choosing the right short talks is crucial for wrapping up our program. We are accepting abstracts until December 3 (11:59pm MST). Submit now for a chance to present in Monte Carlo this February! #KSBCells25 #adaptiveimmunity #germinalcenter youtu.be/W5naij8S6KQ @washumedicine.bsky.social
#MedSky🧪#IDSky #Viralimmunology #ImmunoSky #Tlymphocytes play a primary role in the #Adaptiveimmunity .Both #lymphocytosis & #lymphopenia were found to be associated with severe #SARSCoV2
What is the ‘immune self,’ and how can this concept benefit immunological research? 🔬🧬💡 www.news-medical.net/news/2024051... #Immunology #AdaptiveImmunity #ImmuneSelf #TCells #Immunotherapy #Autoimmunity
Inforgraphic
#MedSky🧪#IDSky Durable #Tcell responses to #SARSCoV2 antigens after infection or vaccination improve immune-mediated #viralclearance. To date, population-based surveys of #COVID19 #adaptiveimmunity have focused on testing for IgG antibodies that bind spike protein and/or neutralize the virus.
