#LongNonCodingRNA Liver Fibrosis
LncRNA TILAM
👉Enriched in Activated Hepatic Stellate Cell
👉Located near COL1A1
👉TGFβ-inducible
👉Physically binds to PML➡️maintains PML protein & TGFβ signaling
TILAM LNA or KO⏬Fibrosis in Liver organoid
TILAM KO ⏬🐭Fibrosis
#HEP 2023
journals.lww.com/hep/fulltext...
Discover the significance of long non-coding RNAs with Novogene’s lncRNA sequencing services. Gain insights into gene regulation and disease mechanisms.
Learn more: https://bit.ly/3DpuzLZ
#lncRNA #LongNonCodingRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation
The LINC01612-DVL2-WNT regulatory axis promotes human endoderm differentiation – a key modulator of human definitive endoderm differentiation. #longnoncodingRNA #DVL2 #WNT #endoderm https://ow.ly/zvgJ50XhLB8
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
The emerging roles of long non-coding RNAs in the nervous system. #LongNonCodingRNA #NervousSystem #Genomics @natrevneuro.nature.com 🧬
www.nature.com/articles/s41...
Discover the significance of long non-coding RNAs with Novogene’s lncRNA sequencing services. Gain insights into gene regulation and disease mechanisms.
Learn more: bit.ly/3DpuzLZ
#lncRNA #LongNonCodingRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation
Peppered Moth. Image credit: Shutterstock/IanRedding.
#NoncodingRNA drives #evolution and #speciation in the #PepperedMoth, #butterflies, and #MonkeyFlower. Could it also shape #HumanCognition and other #flora and #fauna? A PNAS Inner Workings: www.pnas.org/doi/10.1073/...
#microRNA #LongNoncodingRNA
Two pink flowers grow in a patch of grass. Only in recent years have researchers discovered that noncoding RNAs have a significant role in the evolution of the oft-studied plant model system, monkeyflowers. Image credit: Science Source/Stuart Wilson.
#NoncodingRNA plays a crucial role in #butterfly #speciation and #evolution. But what about other #flora and #fauna—or even the #evolution of human #cognition? A PNAS Inner Workings: www.pnas.org/doi/10.1073/...
#microRNA #LongNoncodingRNA #PepperedMoth #MonkeyFlower
Four peppered moths on a rock. Recent research suggests that the famous case study of peppered moth evolution has a new twist: their intriguing coloration changes are driven by RNA molecules that don’t code for proteins. How common these cases are is still up for debate. Image credit: Shutterstock/IanRedding.
#NoncodingRNA plays a crucial role in #butterfly #speciation—but what about other #flora and #fauna? A PNAS Inner Workings: www.pnas.org/doi/10.1073/...
#microRNA #LongNoncodingRNA #evolution #PepperedMoth #MonkeyFlower
Discover the significance of long non-coding RNAs with Novogene’s lncRNA sequencing services. Gain insights into gene regulation and disease mechanisms.
Learn more: bit.ly/3DpuzLZ
#lncRNA #LongNonCodingRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation
Discover the significance of long non-coding RNAs with Novogene’s lncRNA sequencing services. Gain insights into gene regulation and disease mechanisms.
Learn more: bit.ly/3DpuzLZ
#lncRNA #LongNonCodingRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation
#LongNoncodingRNA #SmoothMuscleCell #Seneascence #Atherosclerosis
LncRNA JPX (just proximal to XIST), in complex with #BRD4 NF-κB, transcriptionally activates #SASP in senescent SMCs
SMC Jpx KO⏬🐭#Atherosclerosis +⏬lesional SMC senescence SASP
#ATVB 2024
www.ahajournals.org/doi/10.1161/...
#LongNonCodingRNA #Senescence #Atherosclerosis
JPX, a chromosome-associated regulatory RNA, complexes with BRD4 & p65 (NFκB subunit) to mediates 3D chromatin remodeling &⏫transcriptional activation of senescence secretome in #SmoothMuscleCell
#ATVB 2024
www.ahajournals.org/doi/10.1161/...
#LongNonCodingRNA #LncRNA transcriptomics Lower-extremity #PeripheralArteryDisease -/+ T2D #Diabetes
Iliac artery n=79
T2D->⏬ACTA2-AS1
#SmoothMuscleCell microdissected from FFPE section
T2D->⏫LINC00910/RUFY1-AS1 ⏬HIF1A-AS3/XIST!/NEAT1/MIR222HG
#SciReports 2024
www.nature.com/articles/s41...
#LongNonCodingRNA #SmoothMuscleCell
LncDACH1⏬SMC proliferation+migration & #Neointima of #ArterioVenousFistula, partially via ⏬HSP90 abundance & sequestrating SRPK1 in the nuclei
A similar pro-intimal role in #Atherosclerosis?
#NatureComms 2024
www.nature.com/articles/s41...
Enhancer-associated #LongNonCodingRNA #Atherosclerosis
PSMB8-AS1⏫promixal gene transcription of PSMB9 in #EndothelialCell->
Zeb1->
VCAM1/ICAM1->
#VascularInflammation #Atherosclerosis
Serum lipids also regulated by PSMB8-AS1
#CircRes 2023
www.ahajournals.org/doi/10.1161/...
