Twenty years of experience rarely lead to small changes.

This is just a glimpse of what we’ve been working on, shaped by:

✔️ Years of feedback
✔️ Evolving experimental demands
✔️ Changing expectations around data quality and scale in electrophysiology

Full reveal at #BPS2026.

#PatchClamp #20years

We love to hear how our reagents perform in the lab. An electrophysiologist at Stanford University shared great feedback on our ready-made Cesium Gluconate 👨‍🔬🔬

We're proud to offer high quality products at up to half the price of other suppliers: ow.ly/v9fz50Y4UUn

#electrophysiology #patchclamp

Cantu syndrome–associated SUR2[H60Y] mutation confers selective gain of function on Kir6.1 ATP-sensitive potassium channels Gain-of-function (GOF) mutations in either Kir6.1 (encoded by KCNJ8) or SUR2 (encoded by ABCC9) are causally associated with Cantu syndrome (CS), characterized by coarse facial appearance, hypertricho...

The Cantu-syndrom H60Y mutation in the SUR2 subunit of ATP-sensitive potassium channels results in gain of function only when paired with Kir6.1. New Dynaflow publication in Journal of Biological Chemistry.

👉 www.jbc.org/article/S002...
@asbmbjournals.bsky.social #science #patchclamp #ionchannels

Don't miss this great coming meeting on channelopathies. Early bird registration until Dec 15th. #channelopathies #channelopathy #ionchannel #neuroscience #disease #physiology #pharmacology #electrophysiology #patchclamp

Post a non-religious photo you think of as holy
#PainResearch #Neurons #PatchClamp

A framed imaging showing two pyramidal neurons filled with biocytin (cyan) embedded in a sea of NeuN signals (magenta).

The last two cells I patched! They are by no means my best fills, but definitely the most memorable. Also a reminder to new patchers that lousy fills do not indicate bad cells- some of my best recordings didn’t have great fills. (Ah I miss patching🥹)

#patchclamp #electrophysiology

One of the most beautiful things in the world❤️ #patchclamp #EIRatio

Research Service | Cell and Tissue Patch-Clamp Recording and Analysis Services Explore Brain Case Biotech’s cell and tissue patch-clamp recording services—offering precise ion channel, synaptic, and electrophysiological analysis for neuroscience

🔬 The patch-clamp technique enables precise recording of ion channel and neuronal activity—key for studying excitability and synaptic transmission.
Brain Case Biotech provides full patch-clamp recording & analysis for cells and brain tissue. 🔍 www.ebraincase.com/news/corpora...

#PatchClamp #Neural

Patch-Clamp Single-Cell Proteomics in Acute Brain Slices: A Framework for Recording, Retrieval, and Interpretation Single-cell proteomics (SCP) is a powerful method for interrogating the molecular composition of neurons, yet its application to acute brain slices has remained limited. Patch-clamp electrophysiology ...

Our patch-clamp single-cell proteomics preprint is out! Long story short: we show you how combining patch-clamp with mass spectrometry can reveal ion channels, GPCRs, and other proteins directly linked to neuronal excitability and signaling #patchclamp #electrophysiology #singlecellproteomics

Electrophysiology protocols for LTP and LTD: Recording synaptic… Learn how to record LTP and LTD using whole-cell patch clamp. Step-by-step guide to measuring synaptic plasticity in individual neurons

Planning to record LTP or LTD in acute brain slices with whole-cell patch clamp? Give my latest article on Scientifica's NeuroWire a look! www.scientifica.uk.com/learning-zon... #plasticity #patchclamp #electrophysiology #ephys 🔬🪄⚡️

I can never get bored of recording action potentials from my iPSC sympathetic neurons and the RMP was -70mV 😍 #patchclamp #ephys

During corticogenesis, progenitor competence changes over time — generating distinct excitatory neuron types.
But it turns out that in inhibitory lineages, progenitors retain more stable differentiation competence. Instead, temporal progression alters maturation dynamics.
#PatchClamp
(2/n)

One last chance, course is not fully subscribed yet!

#biophysics #patchclamp #TIRF

patch clamp technique #patchclamp #metinaytekin

How do CaV1.2 mutations drive both arrhythmias and neuro symptoms in Timothy syndrome?

Join Ivy Dick on June 12 to learn how high-throughput patch clamp reveals mutation-specific gating changes tied to clinical outcomes.

📍https://ow.ly/PxZY50W72H7

#PatchClamp #Channelopathies #IonChannels

#neuroscience #micromanipulation #electrophysiology #ScanImage #autopatch #patchclamp #LifeSciences #labautomation #neurotech #researchtools

Monosynaptic IPSCs evoked in a pyramidal neuron by stimulating a nearby PV interneuron

Some beautiful IPSCs for your Friday! #patchclamp

Automated patch clamp for ENaC drug discovery - Nanion Technologies The epithelial sodium channel (ENaC) plays a central role in regulating sodium balance, blood pressure, and pulmonary fluid clearance. Despite its clinical relevance, progress in discovering new ENaC-...

In a recent study, researchers developed and validated an automated #patchclamp ( #APC ) approach using the SyncroPatch 384 platform to detect #ENaC - mediated currents in a high-throughput format.

Read more here:
www.nanion.de/news/automat...

All those GABAs from mouse V1 #patchclamp

(Should mention these are recorded with a high Cl internal thus the outward currents)

An exhibition table at the German Neuroscience Society meeting. The table is set up with two different microscope systems. One focused on live cell and confocal imaging, the other on combining imaging and patch clamp recordings. Behind the table are two company representatives. One from Ultimeyes/Cairn GmbH, the other from Teledyne Photometrics.

We are all set at the Göttingen Meeting of the @neurowissg.bsky.social... Drop by booth 62 to see what we have brought along ( #patchclamp and #imaging ), but also to share stories of your biggest experimental victories 🥳 and challenges 😶‍🌫️!

Such a good feeling to get data again #patchclamp

Working with toxins & ion channels? Testing multiple fractions and screening channels with limited samples is tough. That’s why more scientists are turning to automated patch clamp for faster, reliable results. Curious? Learn more: www.nanion.de/application-... #ionchannels #toxins #patchclamp

Optical control of Kv1.2 channels via azobenzene-modified charybdotoxin - Nanion Technologies Animal venom peptides like charybdotoxin (ChTx) are known for their high specificity and potency as potassium channel blockers, making them valuable tools in ion channel research. However, achieving p...

In a pioneering study, Achouba et al. successfully integrated photoswitch technology into a complex, disulfide-rich peptide ChTx while retaining high nanomolar potency for ion channels.

Read more here:
www.nanion.de/news/optical...

#ionchannels #optogenetics #patchclamp #APC #venom #toxins

Key point: Optogenetic stimulation of dentate gyrus granule cells leads to strong synaptic activation of mossy cells.
doi.org/10.1111/epi....

#epilepsy #ILAE #channelrhodopsin2 #excitotoxicity #patchclamp #retigabine #temporallobeepilepsy

Light-gating of potassium-selective channelrhodopsin - Nanion Technologies Channelrhodopsins (ChRs) are light-sensitive ion channels widely used in optogenetics to precisely control neuronal and cardiac activity. While most ChRs conduct cations non-selectively, a specialized...

A recent study provides detailed structural insights into how potassium-selective channelrhodopsins (KCRs) function.

Read here:
www.nanion.de/news/light-g...

#ionchannels #optogenetics #patchclamp #APC

🧪
#ionchannel
#biophysics
#patchclamp
#academia
#science

An electrophysiology rig being taken apart for cleaning

When the outside world is crazy, you go find solace by deep-cleaning your slice rig.

By the way, any ground box suggestion?

#patchclamp #electrophysiology #neuroskyence #neuroscience

Direct Access and Control of the Intracellular Solution Environment in Single Cells Methods that can control and vary the solution environment around single cells are abundant. In contrast, methods that offer direct access to the intracellular proteome and genome in single cells with...

Controlling the environment inside cells is a major challenge. Olofsson et al. have created a pore formation method for microfluidic single-cell solution exchange that makes it possible to initiate enzymatic reactions and to generate intracellular oscillations and gradients.
#JournalClub #PatchClamp

Getting quite close to the deadline for this fully funded PhD studentship combining AI development (the #ArtificialIntelligence type the Gov is pushing!), #PatchClamp #Ionchannel research and stem cells... did I miss any buzzwords?
Code or Wanna learn???
Deadline 31st January.