Function | New Article Alert! 🚨This review examines how excessive alcohol use can damage peripheral nerves and increase pain sensitivity, and proposes #MitochondrialDysfunction as a key mechanism linking chronic pain and #AlcoholUseDisorder. Read https://ow.ly/EKff50Yrvc9

Exploring the synergistic link between #MitochondrialDysfunction, metabolic stress, and calcium imbalance in #AlzheimersDisease, with insights into the triad's clinical relevance and need for #Biomarker-driven multi-target therapies.

#OpenAccess: doi.org/10.1016/j.ge...

The Latest Research on Mitochondrial Dysfunction in Long Covid & ME/CFS | With Prof. Klaus Wirth YouTube video by Gez Medinger

🧪#LongCovid
#MitochondrialDysfunction
Mitochondrial dysfunction or MCAS or dysautomnia
@Prof
Klaus Wirth

youtu.be/9gwMw69XCP0?...

Dr. Natalie Yivgi-Ohana, Ph.D. - CEO, Minovia - Harnessing The Therapeutic Power Of Mitochondria YouTube video by Progress, Potential, and Possibilities

Harnessing The Therapeutic Power Of Mitochondria - Dr. Natalie Yivgi-Ohana, Ph.D. - CEO, #Minovia Therapeutics joins me on Progress, Potential, And Possibilities #MitochondrialDysfunction #RareDiseases #Aging #Longevity #MitochondrialAugmentationTechnology www.youtube.com/watch?v=jS83...

Molecular landscape of cells within the vitreous of end-stage PDR patients identified PDR as a heterogeneous disease comprising distinct subtypes driven by either immune-mediated vessel clearance or endothelial #MitochondrialDysfunction.

#STTT #OpenAccess: doi.org/10.1038/s413...

Bulk and single-cell RNA sequencing links #MitochondrialDysfunction to sex dimorphism in #cystinuria, showing that restoring #renal #tubular mitochondria in males reduces cell death and #fibroinflammation. @sjtu1896

#OpenAccess: doi.org/10.1016/j.ge...

Elucidating the integrated network of #CircadianRhythms, #SleepDisorders, and #MitochondrialDysfunction in #ParkinsonsDisease, highlighting how SCN-nigrostriatal and gut-brain oscillations drive #Neurodegeneration.

#OpenAccess: doi.org/10.1016/j.ge...

This review describes the relationship between #mtDNA integrity and #CardiacFunction, the associated regulatory pathways and the mechanisms driving #MitochondrialDysfunction and #Ischemia/#Reperfusion-induced cardiomyocyte injury. #medsky

#OpenAccess: doi.org/10.1016/j.ge...

The molecular landscape of endothelial & #ImmuneCells in end-stage PDR patients reveals a heterogeneous disease driven either by immune-mediated clearance of pathological vessels or by endothelial #MitochondrialDysfunction.

#STTT #OpenAccess: doi.org/10.1038/s413...

#AngiotensinII #Cardiomyocyte #Ferroptosis #AtrialFibrillation

AAV-expressed GSTP1, GST isoenzyme, rescues ANGII-cardiomyocyte
#LipidPeroxidation
#MitochondrialDysfunction
#Ferroptosis
🫀Fibrosis
Susceptibility to electrical AF

#Europace 2025 @escardio.bsky.social
academic.oup.com/europace/art...

This review highlights the links between #obesity and #aging, noting shared hallmarks like #inflammation, #telomere loss, and #MitochondrialDysfunction, and emphasizes the potential of #AntiObesity therapies to combat age‑related diseases.

#OpenAccess: doi.org/10.1016/j.ge...

This review discusses #MitochondrialDysfunction in #ParkinsonsDisease (PD), its molecular mechanisms, and the role of mitochondrial dysfunction in aging microglia and astrocytes in PD #Pathogenesis, highlighting future research directions.

#OpenAccess: doi.org/10.1016/j.ge...

KLHL24 mutation drives intermediate filament degradation, mitochondrial dysfunction and fibrosis in heart failure patients.
Chen, H Sophia et al.
Paper
Details
#HeartFailure #MitochondrialDysfunction #Fibrosis

[BioRxiv] Mitoxantrone Hydrochloride Targets APP and LRRK2 to Improve Neurodegeneration in Parkinson's Models

https://doi.org/10.1101/2025.10.06.680832

#neurodegeneration #biorxiv #Neurodegeneration #amyloid #neurotoxicity #mitochondrialdysfunction

[BioRxiv] Genetic ablation of neuronal mitochondrial calcium uptake halts Alzheimer's disease progression

https://doi.org/10.1101/2023.10.11.561889

#neurodegeneration #biorxiv #Alzheimers #mitochondrialdysfunction #synapticdysfunction

The molecular landscape of endothelial & immune cells within the vitreous of end-stage PDR patients showed that PDR is a heterogeneous disease comprising distinct forms defined by immune defense or by endothelial #MitochondrialDysfunction.

#OpenAccess: doi.org/10.1038/s413...

This study profiles #Endothelial and #ImmuneCells from #Vitrectomy samples of #ProliferativeDiabeticRetinopathy, revealing distinct subtypes driven by immune-mediated vessel clearance or endothelial #MitochondrialDysfunction. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

This latest study shows that Yanghe Decoction suppresses #Osteosarcoma (OS) cell processes by inducing #Apoptosis, #MitochondrialDysfunction & boosting #cisplatin sensitivity, promising synergistic approaches to OS treatment. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Latest review highlights #MitochondrialTransplantation as a novel therapeutic strategy with the potential to restore #MitochondrialDysfunction and improve #LungDisease outcomes. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Pungent odors in the air?
"Since 4-nitrocatechol forms when biomass smoke reacts with urban air pollutants like nitrogen oxides, areas affected by both wildfires and traffic pollution may be particularly at risk."
doi.org/10.1016/j.en...
#Mitochondrialdysfunction
/2

Metabolic neuroimaging of myalgic encephalomyelitis/chronic fatigue syndrome and Long-COVID Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID are complex, disabling conditions that have emerged as significant public health challenges, affecting millions worldwide. De...

pmc.ncbi.nlm.nih.gov/articles/PMC...
Metabolic imaging and other studies suggest both conditions involve a reduced capacity for energy production, with evidence pointing toward #mitochondrialdysfunction.

The role of mitochondria in regulating #OxidativeStress, #inflammation, & #aging; how #MitochondrialDysfunction contributes to various diseases; and mitochondrial therapies, their limitations, and future perspectives. #medsky

#STTT #OpenAccess: www.nature.com/articles/s41...

Icarin exerts #neuroprotective effects against D-gal-induced #NeuronalInjury and #apoptosis by improving #MitochondrialDysfunction and by inhibiting excessive autophagy through blocking #MitochondrialPermeabilityTransitionPore (mPTP) opening. #medsky

#MostCited #OpenAccess: buff.ly/ujbFGgK

The Human LRRK2-R1441G Mutation Drives Age-Dependent Oxidative Stress and Mitochondrial Dysfunction in Dopaminergic Neurons
Chen, Y., Cui, S. et al.
Paper
Details
#LRRK2Mutation #MitochondrialDysfunction #Neurodegeneration

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where symptoms worsen with cognitive or physical exertion. PEM often results in avoidance of physical activity, resulting in a lower aerobic fitness, which may contribute to skeletal muscle abnormalities. Here, we compared whole-body exercise responses and skeletal muscle adaptations after strict 60-day bed rest in healthy people with those in patients with long COVID and ME/CFS, and healthy age- and sex-matched controls. Bed rest altered the respiratory and cardiovascular responses to (sub)maximal exercise, while patients exhibited respiratory alterations only at submaximal exercise. Bed rest caused muscle atrophy, and the reduced oxidative phosphorylation related to reductions in maximal oxygen uptake. Patients with long COVID and ME/CFS did not have muscle atrophy, but had less capillaries and a more glycolytic fibers, none of which were associated with maximal oxygen uptake. While the whole-body aerobic capacity is similar following bed rest compared to patients, the skeletal muscle characteristics differed, suggesting that physical inactivity alone does not explain the lower exercise capacity in long COVID and ME/CFS. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study was supported the Patient-Led Research Collaborative for Long COVID, the AMC and VU foundation, ZonMw Onderzoeksprogramma for ME/CVS, the Solve ME 2022 Ramsay Grant Program, ME Research UK, ME Stars of Tomorrow Scholarship award from the ICanCME Research Network (to B.T.C.), and Stichting Long COVID Nederland. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Ethics committee of Amsterdam UMC, Medical Association North Rhine (number 2018143) and NASA (Johnson Space Center, Houston, United States) gave ethical approval for this work. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest
doi.org/10.1101/2025...

#ME/CFS #LongCovid #PEM #MitochondrialDysfunction #PostExertionalMalaise #ChronicIllness #EnergyMetabolism
1/8

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where symptoms worsen with cognitive or physical exertion. PEM often results in avoidance of physical activity, resulting in a lower aerobic fitness, which may contribute to skeletal muscle abnormalities. Here, we compared whole-body exercise responses and skeletal muscle adaptations after strict 60-day bed rest in healthy people with those in patients with long COVID and ME/CFS, and healthy age- and sex-matched controls. Bed rest altered the respiratory and cardiovascular responses to (sub)maximal exercise, while patients exhibited respiratory alterations only at submaximal exercise. Bed rest caused muscle atrophy, and the reduced oxidative phosphorylation related to reductions in maximal oxygen uptake. Patients with long COVID and ME/CFS did not have muscle atrophy, but had less capillaries and a more glycolytic fibers, none of which were associated with maximal oxygen uptake. While the whole-body aerobic capacity is similar following bed rest compared to patients, the skeletal muscle characteristics differed, suggesting that physical inactivity alone does not explain the lower exercise capacity in long COVID and ME/CFS. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study was supported the Patient-Led Research Collaborative for Long COVID, the AMC and VU foundation, ZonMw Onderzoeksprogramma for ME/CVS, the Solve ME 2022 Ramsay Grant Program, ME Research UK, ME Stars of Tomorrow Scholarship award from the ICanCME Research Network (to B.T.C.), and Stichting Long COVID Nederland. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Ethics committee of Amsterdam UMC, Medical Association North Rhine (number 2018143) and NASA (Johnson Space Center, Houston, United States) gave ethical approval for this work. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest
doi.org/10.1101/2025...

#ME/CFS #LongCovid #PEM #MitochondrialDysfunction #PostExertionalMalaise #ChronicIllness #EnergyMetabolism
1/7

IFI204 in microglia mediates traumatic brain injury-induced mitochondrial dysfunction and pyroptosis via SENP7 interaction.

https://pubmed.ncbi.nlm.nih.gov/40407969/

#neurodegeneration #mitochondrialdysfunction

Increased LETM1 expression in #Osteosarcoma (OS) cells is associated with #MitochondrialDysfunction, while LETM1 knockdown partially restores mitochondrial structure & function and increases #OsteogenicDifferentiation of OS cells. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...